1XK2
NADPH- and Ascorbate-Supported Heme Oxygenase Reactions are Distinct. Regiospecificity of Heme Cleavage by the R183E Mutant
Summary for 1XK2
| Entry DOI | 10.2210/pdb1xk2/pdb |
| Related | 1Xk3 |
| Descriptor | Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total) |
| Functional Keywords | heme, heme degradation, catalytic mechanism, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Cellular location | Microsome: P09601 |
| Total number of polymer chains | 2 |
| Total formula weight | 54974.04 |
| Authors | Wang, J.,Lad, L.,Poulos, T.L.,Ortiz de montellano, P.R. (deposition date: 2004-09-26, release date: 2004-11-09, Last modification date: 2024-02-14) |
| Primary citation | Wang, J.,Lad, L.,Poulos, T.L.,Ortiz de montellano, P.R. Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant. J.Biol.Chem., 280:2797-2806, 2005 Cited by PubMed: 15525643DOI: 10.1074/jbc.M411229200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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