3CZY

Crystal Structure of Human Heme Oxygenase-1 in Complex with 1-(Adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone

Summary for 3CZY

Entry DOI	10.2210/pdb3czy/pdb
Descriptor	Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone, ... (4 entities in total)
Functional Keywords	heme oxygenase-1 inhibitor complex, endoplasmic reticulum, heme, iron, metal-binding, microsome, oxidoreductase, phosphoprotein, polymorphism
Biological source	Homo sapiens (human)
Cellular location	Microsome: P09601
Total number of polymer chains	2
Total formula weight	55518.87
Authors	Jia, Z.,Rahman, M.N. (deposition date: 2008-04-30, release date: 2008-09-30, Last modification date: 2023-08-30)
Primary citation	Rahman, M.N.,Vlahakis, J.Z.,Szarek, W.A.,Nakatsu, K.,Jia, Z. X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors. J.Med.Chem., 51:5943-5952, 2008 Cited by PubMed: 18798608 DOI: 10.1021/jm800505m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation