3K4F
X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 4-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone
Summary for 3K4F
Entry DOI | 10.2210/pdb3k4f/pdb |
Related | 1N45 3CZY 3HOK |
Descriptor | Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 4-phenyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one, ... (6 entities in total) |
Functional Keywords | heme oxygenase-1 inhibitor complex, alpha helices, endoplasmic reticulum, heme, iron, metal-binding, microsome, oxidoreductase, phosphoprotein, polymorphism |
Biological source | Homo sapiens (human) |
Cellular location | Microsome: P09601 |
Total number of polymer chains | 2 |
Total formula weight | 55889.18 |
Authors | Rahman, M.N.,Jia, Z. (deposition date: 2009-10-05, release date: 2009-12-15, Last modification date: 2023-09-06) |
Primary citation | Roman, G.,Rahman, M.N.,Vukomanovic, D.,Jia, Z.,Nakatsu, K.,Szarek, W.A. Heme Oxygenase Inhibition by 2-Oxy-substituted 1-Azolyl-4-phenylbutanes: Effect of Variation of the Azole Moiety. X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 4-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. Chem.Biol.Drug Des., 75:68-90, 2010 Cited by PubMed: 19954435DOI: 10.1111/j.1747-0285.2009.00909.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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