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7JUJ
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BU of 7juj by Molmil
Cruzain bound to Gallinamide inhibitor
Descriptor: Cruzipain, POTASSIUM ION, gallinamide A, ...
Authors:Silva, E.B, Sharma, V, Alvarez, L.H, Gerwick, W.H, McKerrow, J.H, Podust, L.M.
Deposit date:2020-08-19
Release date:2021-08-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi .
J.Med.Chem., 65, 2022
7NXM
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BU of 7nxm by Molmil
Structure of human cathepsin K in complex with the selective activity-based probe Gu3416
Descriptor: Cathepsin K, N-(4-(dibenzylamino)-4-oxobutyl)-2-(5-(dimethylamino)pentanamido)-4-methylpentanamide, SULFATE ION
Authors:Busa, M, Benysek, J, Lemke, C, Gutschow, M, Mares, M.
Deposit date:2021-03-18
Release date:2021-09-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity.
J.Med.Chem., 64, 2021
7NXL
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BU of 7nxl by Molmil
Structure of human cathepsin K in complex with the acrylamide inhibitor Gu3110
Descriptor: Cathepsin K, SULFATE ION, tert-butyl (1-((4-(dibenzylamino)-4-oxobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate
Authors:Busa, M, Benysek, J, Lemke, C, Gutschow, M, Mares, M.
Deposit date:2021-03-18
Release date:2021-09-08
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity.
J.Med.Chem., 64, 2021
8C3D
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BU of 8c3d by Molmil
Sulfonated Calpeptin is a promising drug candidate against SARS-CoV-2 infections
Descriptor: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CALCIUM ION, Cathepsin K
Authors:Loboda, J, Karnicar, K, Lindic, N, Usenik, A, Lieske, J, Meents, A, Guenther, S, Reinke, P.Y.A, Falke, S, Ewert, W, Turk, D.
Deposit date:2022-12-23
Release date:2023-09-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
Commun Biol, 6, 2023
2ACT
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BU of 2act by Molmil
CRYSTALLOGRAPHIC REFINEMENT OF THE STRUCTURE OF ACTINIDIN AT 1.7 ANGSTROMS RESOLUTION BY FAST FOURIER LEAST-SQUARES METHODS
Descriptor: ACTINIDIN PRECURSOR, AMMONIUM ION
Authors:Baker, E.N.
Deposit date:1979-11-27
Release date:1980-03-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystallographic Refinement of the Structure of Actinidin at 1.7 Angstroms Resolution by Fast Fourier Least-Squares Methods
Acta Crystallogr.,Sect.A, 36, 1980
8CCU
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BU of 8ccu by Molmil
Cathepsin B1 from Schistosoma mansoni in complex with gallinamide analog 1
Descriptor: Cathepsin B-like peptidase (C01 family), SODIUM ION, [(2~{S})-1-[[(2~{S})-1-[[(2~{S})-5-[(2~{S})-3-methoxy-2-(2-methylpropyl)-5-oxidanylidene-2~{H}-pyrrol-1-yl]-5-oxidanylidene-pentan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl] (2~{S},3~{S})-2-(dimethylamino)-3-methyl-pentanoate
Authors:Rubesova, P, Brynda, J, Gerwick, W.H, Mares, M.
Deposit date:2023-01-27
Release date:2024-02-07
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
Acs Infect Dis., 10, 2024
8CC2
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BU of 8cc2 by Molmil
Cathepsin B1 from Schistosoma mansoni in complex with gallinamide A
Descriptor: Cathepsin B-like peptidase (C01 family), SODIUM ION, gallinamide A, ...
Authors:Rubesova, P, Brynda, J, Mares, M, Gerwick, W.H.
Deposit date:2023-01-26
Release date:2024-02-07
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
Acs Infect Dis., 10, 2024
6X44
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BU of 6x44 by Molmil
High Resolution Crystal Structure Analysis of SERA5 proenzyme from plasmodium falciparum
Descriptor: DI(HYDROXYETHYL)ETHER, Serine repeat antigen 5
Authors:Clarke, O.B, Smith, N.A, Lee, M, Smith, B.J.
Deposit date:2020-05-22
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.19733953 Å)
Cite:Structure of the Plasmodium falciparum PfSERA5 pseudo-zymogen.
Protein Sci., 29, 2020
2ATO
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BU of 2ato by Molmil
Crystal structure of Human Cathepsin K in complex with myocrisin
Descriptor: (S)-(1,2-DICARBOXYETHYLTHIO)GOLD, Cathepsin K, SULFATE ION
Authors:Weidauer, E, Yasuda, Y, Biswal, B.K, Kerr, L.D, Cherney, M.M, Gordon, R.E, James, M.N.G, Bromme, D.
Deposit date:2005-08-25
Release date:2006-08-29
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S.
Biol.Chem., 388, 2007
2B1N
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BU of 2b1n by Molmil
Crystal structure of a papain-fold protein without the catalytic cysteine from seeds of Pachyrhizus erosus
Descriptor: SPE31, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, peptide (LYS)(ALA)(SER)(VAL)(GLY)
Authors:Zhang, M, Wei, Z, Chang, S.
Deposit date:2005-09-16
Release date:2006-10-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a papain-fold protein without the catalytic residue: a novel member in the cysteine proteinase family
J.Mol.Biol., 358, 2006
6X42
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BU of 6x42 by Molmil
High Resolution Crystal Structure Analysis of SERA5E from plasmodium falciparum
Descriptor: 1,2-ETHANEDIOL, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, CALCIUM ION, ...
Authors:Clarke, O.B, Smith, N.A, Lee, M, Smith, B.J.
Deposit date:2020-05-21
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure of the Plasmodium falciparum PfSERA5 pseudo-zymogen.
Protein Sci., 29, 2020
5I4H
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BU of 5i4h by Molmil
Caught in the Act: The Crystal Structure of cleaved Cathepsin L bound to the active site of Cathepsin L
Descriptor: Cathepsin L1, GLYCEROL, SULFATE ION
Authors:Sosnowski, P, Turk, D.
Deposit date:2016-02-12
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
Febs Lett., 590, 2016
6BKI
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BU of 6bki by Molmil
Crystal structure of T101A variant mouse cathepsin K at 2.94 Angstrom resolution.
Descriptor: Cathepsin K, SULFATE ION
Authors:Law, S, Aguda, A, Brayer, G, Bromme, D.
Deposit date:2017-11-08
Release date:2018-11-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Crystal structure of T101A variant mouse cathepsin K at 2.94 Angstrom resolution.
To Be Published
6Y6L
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BU of 6y6l by Molmil
Structure the ananain protease from Ananas comosus with a thiomethylated catalytic cysteine
Descriptor: Ananain, GLYCEROL, SULFATE ION
Authors:Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F.
Deposit date:2020-02-26
Release date:2020-11-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep, 10, 2020
5J94
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BU of 5j94 by Molmil
Human cathepsin K mutant C25S in complex with the allosteric effector NSC13345
Descriptor: 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid, Cathepsin K, SULFATE ION
Authors:Novinec, M, Korenc, M, Lenarcic, B, Baici, A.
Deposit date:2016-04-08
Release date:2016-04-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.22002459 Å)
Cite:A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods.
Nat Commun, 5, 2014
5JH3
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BU of 5jh3 by Molmil
Human cathepsin K mutant C25S
Descriptor: ACETATE ION, CHLORIDE ION, Cathepsin K, ...
Authors:Novinec, M, Korenc, M, Lenarcic, B.
Deposit date:2016-04-20
Release date:2016-11-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:An allosteric site enables fine-tuning of cathepsin K by diverse effectors.
FEBS Lett., 590, 2016
6ASH
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BU of 6ash by Molmil
Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution
Descriptor: 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid, Cathepsin K
Authors:Law, S, Aguda, A, Nguyen, N, Brayer, G, Bromme, D.
Deposit date:2017-08-24
Release date:2018-08-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.423 Å)
Cite:Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution.
To Be Published
6AY2
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BU of 6ay2 by Molmil
Structure of CathB with covalently linked Compound 28
Descriptor: Cathepsin B, N~1~-[(2S)-1-amino-5-(carbamoylamino)pentan-2-yl]-N'~1~-[(1R)-1-(thiophen-3-yl)ethyl]cyclobutane-1,1-dicarboxamide
Authors:Kiefer, J.R, Steinbacher, S.
Deposit date:2017-09-07
Release date:2017-12-27
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J. Med. Chem., 61, 2018
7E3F
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BU of 7e3f by Molmil
Crystal structure of Trypanosoma brucei cathepsin B Y217C/S275C mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cysteine peptidase C (CPC), beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Abe, S, Pham, T.T, Negishi, H, Yamashita, K, Hirata, K, Ueno, T.
Deposit date:2021-02-08
Release date:2021-12-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Design of an In-Cell Protein Crystal for the Environmentally Responsive Construction of a Supramolecular Filament.
Angew.Chem.Int.Ed.Engl., 60, 2021
7E3G
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BU of 7e3g by Molmil
Crystal structure of Trypanosoma brucei cathepsin B R91C/T223C mutant in the living cell
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cysteine peptidase C (CPC), beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Abe, S, Pham, T.T, Negishi, H, Yamashita, K, Hirata, K, Ueno, T.
Deposit date:2021-02-08
Release date:2021-12-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.86 Å)
Cite:Design of an In-Cell Protein Crystal for the Environmentally Responsive Construction of a Supramolecular Filament.
Angew.Chem.Int.Ed.Engl., 60, 2021
7E3E
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BU of 7e3e by Molmil
Crystal structure of Trypanosoma brucei cathepsin B R91C/T223C mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cysteine peptidase C (CPC), beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Abe, S, Pham, T.T, Negishi, H, Yamashita, K, Hirata, K, Ueno, T.
Deposit date:2021-02-08
Release date:2021-12-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of an In-Cell Protein Crystal for the Environmentally Responsive Construction of a Supramolecular Filament.
Angew.Chem.Int.Ed.Engl., 60, 2021
4W5B
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BU of 4w5b by Molmil
Crystal structure analysis of cruzain with Fragment 1 (N-(1H-benzimidazol-2-yl)-1,3-dimethyl-pyrazole-4-carboxamide)
Descriptor: Cruzipain, N-(1H-benzimidazol-2-yl)-1,3-dimethyl-1H-pyrazole-4-carboxamide
Authors:Tochowicz, A, McKerrow, J.H, Craik, C.S.
Deposit date:2014-08-17
Release date:2015-03-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Applying Fragments Based- Drug Design to identify multiple binding modes on cysteine protease.
To Be Published
4QH6
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BU of 4qh6 by Molmil
Crystal structure of cruzain with nitrile inhibitor N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE
Descriptor: Cruzipain, N-(2-aminoethyl)-Nalpha-benzoyl-L-phenylalaninamide
Authors:Fernandes, W.B, Montanari, C.A, McKerrow, J.H.
Deposit date:2014-05-27
Release date:2015-08-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors.
Plos Negl Trop Dis, 9, 2015
4X6H
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BU of 4x6h by Molmil
Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
Descriptor: 4-amino-3-fluoro-N-(1-{[(2Z)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide, 4-amino-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-3-fluorobenzamide, Cathepsin K, ...
Authors:Borisek, J, Mohar, B, Vizovisek, M, Sosnowski, P, Turk, D, Turk, B, Novic, M.
Deposit date:2014-12-08
Release date:2015-09-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1 Å)
Cite:Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
J.Med.Chem., 58, 2015
4X6J
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BU of 4x6j by Molmil
Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
Descriptor: 2-amino-4-chloro-N-(1-{[(2E)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide, CHLORIDE ION, Cathepsin K, ...
Authors:Borisek, J, Mohar, B, Vizovisek, M, Sosnowski, P, Turk, D, Turk, B, Novic, M.
Deposit date:2014-12-08
Release date:2015-09-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
J.Med.Chem., 58, 2015

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