7JUJ
Cruzain bound to Gallinamide inhibitor
Summary for 7JUJ
Entry DOI | 10.2210/pdb7juj/pdb |
Descriptor | Cruzipain, gallinamide A, bound form, POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | cysteine protease, cruzain, gallinamide, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 6 |
Total formula weight | 140406.87 |
Authors | Silva, E.B.,Sharma, V.,Alvarez, L.H.,Gerwick, W.H.,McKerrow, J.H.,Podust, L.M. (deposition date: 2020-08-19, release date: 2021-08-25, Last modification date: 2023-10-18) |
Primary citation | Barbosa Da Silva, E.,Sharma, V.,Hernandez-Alvarez, L.,Tang, A.H.,Stoye, A.,O'Donoghue, A.J.,Gerwick, W.H.,Payne, R.J.,McKerrow, J.H.,Podust, L.M. Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi . J.Med.Chem., 65:4255-4269, 2022 Cited by PubMed: 35188371DOI: 10.1021/acs.jmedchem.1c02063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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