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5LDH
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BU of 5ldh by Molmil
STRUCTURE OF THE ACTIVE TERNARY COMPLEX OF PIG HEART LACTATE DEHYDROGENASE WITH S-LAC-NAD AT 2.7 ANGSTROMS RESOLUTION
Descriptor: (3S)-5-(3-CARBOXY-3-HYDROXYPROPYL) NICOTINAMIDE-ADENINE-DINUCLEOTIDE, CITRIC ACID, LACTATE DEHYDROGENASE
Authors:Grau, U.M, Rossmann, M.G.
Deposit date:1980-10-29
Release date:1981-03-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the active ternary complex of pig heart lactate dehydrogenase with S-lac-NAD at 2.7 A resolution.
J.Mol.Biol., 151, 1981
6P6U
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BU of 6p6u by Molmil
Crystal Structure of Monoclinic Rabbit Muscle Lactate Dehydrogenase with Four Tetramers as the Asymmetric Unit
Descriptor: ADENOSINE MONOPHOSPHATE, L-lactate dehydrogenase A chain
Authors:McPherson, A.
Deposit date:2019-06-04
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal Structure of Monoclinic Rabbit Muscle Lactate Dehydrogenase with Four Tetramers as the Asymmetric Unit
to be published
9BK2
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BU of 9bk2 by Molmil
Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (S-enantiomer, monoclinic P form)
Descriptor: (2S)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, DIMETHYL SULFOXIDE, L-lactate dehydrogenase A chain, ...
Authors:Lovell, S, Cooper, A, Battaile, K.P, Sharma, H.
Deposit date:2024-04-26
Release date:2024-07-10
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Eur.J.Med.Chem., 275, 2024
7AOB
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BU of 7aob by Molmil
Crystal structure of Thermaerobacter marianensis malate dehydrogenase
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Bertrand, Q, Lasalle, L, Girard, E, Madern, D.
Deposit date:2020-10-14
Release date:2020-10-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Crystal structure of Thermaerobacter marianensis malate dehydrogenase
To Be Published
2LDB
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BU of 2ldb by Molmil
STRUCTURE DETERMINATION AND REFINEMENT OF BACILLUS STEAROTHERMOPHILUS LACTATE DEHYDROGENASE
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Piontek, K, Rossmann, M.G.
Deposit date:1989-03-27
Release date:1989-07-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure determination and refinement of Bacillus stearothermophilus lactate dehydrogenase.
Proteins, 7, 1990
6ITL
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BU of 6itl by Molmil
Crystal structure of malate dehydrogenase from Mannheimia succiniciproducens in complex with NAD
Descriptor: GLYCEROL, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Seo, H, Kim, K.-J.
Deposit date:2018-11-23
Release date:2019-11-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase.
Nat Commun, 11, 2020
3LDH
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BU of 3ldh by Molmil
A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes
Descriptor: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRUVIC ACID
Authors:White, J.L, Hackert, M.L, Buehner, M, Adams, M.J, Ford, G.C, Lentzjunior, P.J, Smiley, I.E, Steindel, S.J, Rossmann, M.G.
Deposit date:1974-06-06
Release date:1977-04-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes.
J.Mol.Biol., 102, 1976
6TXR
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BU of 6txr by Molmil
Structural insights into cubane-modified aptamer recognition of a malaria biomarker
Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Cheung, Y, Roethlisberger, P, Mechaly, A, Weber, P, Wong, A, Lo, Y, Haouz, A, Savage, P, Hollenstein, M, Tanner, J.
Deposit date:2020-01-14
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
Proc.Natl.Acad.Sci.USA, 117, 2020
8FW6
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BU of 8fw6 by Molmil
Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336
Descriptor: (2P)-2-{5-(cyclopropylmethyl)-3-(4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ...
Authors:Lowther, W.T, Gumpena, R.
Deposit date:2023-01-20
Release date:2024-01-24
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Human Lactate Dehydrogenase A in complex with inhibitor CHK-336
To Be Published
5ES3
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BU of 5es3 by Molmil
Co-crystal structure of LDH liganded with oxamate
Descriptor: L-lactate dehydrogenase A chain, OXAMIC ACID
Authors:Nowicki, M.W, Wear, M.A, McNae, I.W, Blackburn, E.A.
Deposit date:2015-11-16
Release date:2016-01-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using AKTAxpressTM.
Plos One, 10, 2015
6H9S
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BU of 6h9s by Molmil
Crystal dimeric structure of Petrotoga mobilis lactate dehydrogenase with NADH
Descriptor: L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Roche, J, Engilberge, S, Girard, E, Madern, D.
Deposit date:2018-08-06
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Petrotoga mobilis lactate dehydrogenase at 1.9 Angstrom resolution
To Be Published
6CEP
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BU of 6cep by Molmil
Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate
Descriptor: L-lactate dehydrogenase B chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID
Authors:Hoffer, E.D, Andrews, B, Dunham, C.M, Dyer, R.B.
Deposit date:2018-02-12
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small molecule cores demonstrate non-competitive inhibition of lactate dehydrogenase.
Medchemcomm, 9, 2018
8LDH
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BU of 8ldh by Molmil
REFINED CRYSTAL STRUCTURE OF DOGFISH M4 APO-LACTATE DEHYDROGENASE
Descriptor: CITRIC ACID, M4 APO-LACTATE DEHYDROGENASE
Authors:Abad-Zapatero, C, Rossmann, M.G.
Deposit date:1988-01-04
Release date:1989-07-12
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Refined crystal structure of dogfish M4 apo-lactate dehydrogenase.
J.Mol.Biol., 198, 1987
1GV0
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BU of 1gv0 by Molmil
Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
Descriptor: MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Dalhus, B, Sarinen, M, Sauer, U.H, Eklund, P, Johansson, K, Karlsson, A, Ramaswamy, S, Bjork, A, Synstad, B, Naterstad, K, Sirevag, R, Eklund, H.
Deposit date:2002-02-04
Release date:2002-02-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
J.Mol.Biol., 318, 2002
6MVA
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BU of 6mva by Molmil
LDHA structure in complex with inhibitor 14
Descriptor: (6R)-6-(3-aminophenyl)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Eigenbrot, C.E, Ultsch, M, Wei, B.
Deposit date:2018-10-24
Release date:2019-10-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structure-based Optimization of Potent, Cell-Active Hydroxylactam Inhibitors of Lactate Dehydrogenase
To Be Published
7NRZ
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BU of 7nrz by Molmil
Crystal structure of malate dehydrogenase from Trypanosoma cruzi
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Sonani, R.R, Kurpiewska, K, Lewinski, K, Dubin, G.
Deposit date:2021-03-04
Release date:2022-02-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Distinct sequence and structural feature of trypanosoma malate dehydrogenase.
Biochem.Biophys.Res.Commun., 557, 2021
1GUZ
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BU of 1guz by Molmil
Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
Descriptor: MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Dalhus, B, Sarinen, M, Sauer, U.H, Eklund, P, Johansson, K, Karlsson, A, Ramaswamy, S, Bjork, A, Synstad, B, Naterstad, K, Sirevag, R, Eklund, H.
Deposit date:2002-02-04
Release date:2002-02-21
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
J.Mol.Biol., 318, 2002
2LDX
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BU of 2ldx by Molmil
CHARACTERIZATION OF THE ANTIGENIC SITES ON THE REFINED 3-ANGSTROMS RESOLUTION STRUCTURE OF MOUSE TESTICULAR LACTATE DEHYDROGENASE C4
Descriptor: APO-LACTATE DEHYDROGENASE
Authors:Griffith, J.P, Rossmann, M.G.
Deposit date:1987-11-25
Release date:1989-04-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Characterization of the antigenic sites on the refined 3-A resolution structure of mouse testicular lactate dehydrogenase C4.
J.Biol.Chem., 262, 1987
7F8D
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BU of 7f8d by Molmil
Malate Dehydrogenase from Geobacillus stearothermophilus (gs-MDH) G218Y mutant
Descriptor: Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Shimozawa, Y, Himiyama, T, Nakamura, T, Nishiya, Y.
Deposit date:2021-07-02
Release date:2022-02-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Increasing loop flexibility affords low-temperature adaptation of a moderate thermophilic malate dehydrogenase from Geobacillus stearothermophilus.
Protein Eng.Des.Sel., 34, 2021
7EPM
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BU of 7epm by Molmil
human LDHC complexed with NAD+ and ethylamino acetic acid
Descriptor: 2-(ethylamino)-2-oxidanylidene-ethanoic acid, L-lactate dehydrogenase C chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Yu, Y, Chen, Q.
Deposit date:2021-04-27
Release date:2022-03-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Identification of human LDHC4 as a potential target for anticancer drug discovery.
Acta Pharm Sin B, 12, 2022
8RS5
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BU of 8rs5 by Molmil
Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 4
Descriptor: CHLORIDE ION, Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Coquille, S, Engilberge, S, Madern, D.
Deposit date:2024-01-24
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Navigating the conformational landscape of an enzyme. Stabilization of a low populated conformer by evolutionary mutations triggers Allostery into a non-allosteric enzyme.
To Be Published
8RWL
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BU of 8rwl by Molmil
Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 1
Descriptor: CHLORIDE ION, GLYCEROL, Malate dehydrogenase, ...
Authors:Coquille, S, Roche, J, Engilberge, S, Girard, E, Madern, D.
Deposit date:2024-02-05
Release date:2024-07-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Navigating the conformational landscape of an enzyme. Stabilization of a low populated conformer by evolutionary mutations triggers Allostery into a non-allosteric enzyme.
To Be Published
6Y91
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BU of 6y91 by Molmil
Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with NADH
Descriptor: Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M.
Deposit date:2020-03-06
Release date:2021-03-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
Commun Biol, 4, 2021
8AB3
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BU of 8ab3 by Molmil
Crystal Structure of the Lactate Dehydrogenase of Cyanobacterium Aponinum in complex with oxamate, NADH and FBP.
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,6-di-O-phosphono-beta-D-fructofuranose, L-lactate dehydrogenase, ...
Authors:Robin, A.Y, Girard, E, Madern, D.
Deposit date:2022-07-04
Release date:2022-07-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.616 Å)
Cite:Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery.
Mol.Biol.Evol., 40, 2023
7P4G
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BU of 7p4g by Molmil
Rabbit Muscle L-lactate dehydrogenase in complex with citrate
Descriptor: CITRIC ACID, L-lactate dehydrogenase A chain
Authors:Iacovino, L.G, Binda, C, Hochkoeppler, A.
Deposit date:2021-07-11
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme.
Biochimie, 199, 2022

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数据于2024-09-18公开中

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