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1LN6
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BU of 1ln6 by Molmil
STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)
Descriptor: RETINAL, RHODOPSIN
Authors:Choi, G, Landin, J, Galan, J.F, Birge, R.R, Albert, A.D, Yeagle, P.L.
Deposit date:2002-05-03
Release date:2002-07-10
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin.
Biochemistry, 41, 2002
6PEL
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BU of 6pel by Molmil
Crystal structure of bovine opsin with citronellol bound
Descriptor: (3R)-3,7-dimethyloct-6-en-1-ol, ILENLKDVGLF G alpha peptide CT2, PALMITIC ACID, ...
Authors:Eger, B.T, Morizumi, T, Ernst, O.P.
Deposit date:2019-06-20
Release date:2020-06-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.186 Å)
Cite:Odorant-binding site in visual opsin
To Be Published
3C9M
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BU of 3c9m by Molmil
Structure of a mutant bovine rhodopsin in hexagonal crystal form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYL GROUP, RETINAL, ...
Authors:Stenkamp, R.E.
Deposit date:2008-02-16
Release date:2008-08-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Alternative models for two crystal structures of bovine rhodopsin.
Acta Crystallogr.,Sect.D, 64, 2008
5X93
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BU of 5x93 by Molmil
Human endothelin receptor type-B in complex with antagonist K-8794
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]oxy-N-(2,6-dimethylphenyl)propanamide, CHOLESTEROL, ...
Authors:Shihoya, W, Nishizawa, T, Yamashita, K, Hirata, K, Okuta, A, Tani, K, Fujiyoshi, Y, Doi, T, Nureki, O.
Deposit date:2017-03-05
Release date:2017-08-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
Nat. Struct. Mol. Biol., 24, 2017
6PGS
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BU of 6pgs by Molmil
Crystal structure of bovine opsin with geraniol bound
Descriptor: G alpha CT2 peptide, Geraniol, PALMITIC ACID, ...
Authors:Eger, B.T, Morizumi, T, Ernst, O.P.
Deposit date:2019-06-24
Release date:2020-07-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.905 Å)
Cite:Odorant-binding site in visual opsin
To Be Published
6PH7
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BU of 6ph7 by Molmil
Crystal structure of bovine opsin with nerol bound
Descriptor: (2Z)-3,7-dimethylocta-2,6-dien-1-ol, G protein CT2 peptide, PALMITIC ACID, ...
Authors:Eger, B.T, Morizumi, T, Ernst, O.P.
Deposit date:2019-06-25
Release date:2020-07-01
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.902 Å)
Cite:Odorant-binding site in visual opsin
To Be Published
5X33
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BU of 5x33 by Molmil
Leukotriene B4 receptor BLT1 in complex with BIIL260
Descriptor: 4-[[3-[[4-[2-(4-hydroxyphenyl)propan-2-yl]phenoxy]methyl]phenyl]methoxy]benzenecarboximidamide, LTB4 receptor,Lysozyme,LTB4 receptor
Authors:Hori, T, Hirata, K, Yamashita, K, Kawano, Y, Yamamoto, M, Yokoyama, S.
Deposit date:2017-02-03
Release date:2018-01-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Na+-mimicking ligands stabilize the inactive state of leukotriene B4receptor BLT1.
Nat. Chem. Biol., 14, 2018
5XPR
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BU of 5xpr by Molmil
Human endothelin receptor type-B in complex with antagonist bosentan
Descriptor: 4-tert-butyl-N-[6-(2-hydroxyethyloxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]benzenesulfonamide, Endothelin B receptor,Endolysin,Endothelin B receptor, SULFATE ION
Authors:Shihoya, W, Nishizawa, T, Yamashita, K, Hirata, K, Okuta, A, Tani, K, Fujiyoshi, Y, Doi, T, Nureki, O.
Deposit date:2017-06-04
Release date:2017-08-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
Nat. Struct. Mol. Biol., 24, 2017
5XSZ
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BU of 5xsz by Molmil
Crystal structure of zebrafish lysophosphatidic acid receptor LPA6
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lysophosphatidic acid receptor 6a,Endolysin,Lysophosphatidic acid receptor 6a
Authors:Taniguchi, R, Nishizawa, T, Ishitani, R, Nureki, O.
Deposit date:2017-06-16
Release date:2017-08-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6
Nature, 548, 2017
6PRZ
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BU of 6prz by Molmil
XFEL beta2 AR structure by ligand exchange from Alprenolol to Alprenolol.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, CHOLESTEROL, ...
Authors:Ishchenko, A, Stauch, B, Han, G.W, Batyuk, A, Shiriaeva, A, Li, C, Zatsepin, N.A, Weierstall, U, Liu, W, Nango, E, Nakane, T, Tanaka, R, Tono, K, Joti, Y, Iwata, S, Moraes, I, Gati, C, Cherezov, C.
Deposit date:2019-07-12
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
Iucrj, 6, 2019
5XRA
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BU of 5xra by Molmil
Crystal structure of the human CB1 in complex with agonist AM11542
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (6aR,10aR)-3-(8-bromanyl-2-methyl-octan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, CHOLESTEROL, ...
Authors:Hua, T, Vemuri, K, Nikas, P.S, Laprairie, R.B, Wu, Y, Qu, L, Pu, M, Korde, A, Shan, J, Ho, J.H, Han, G.W, Ding, K, Li, X, Liu, H, Hanson, M.A, Zhao, S, Bohn, L.M, Makriyannis, A, Stevens, R.C, Liu, Z.J.
Deposit date:2017-06-08
Release date:2017-07-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature, 547, 2017
6PS1
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BU of 6ps1 by Molmil
XFEL beta2 AR structure by ligand exchange from Alprenolol to Timolol.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol, CHOLESTEROL, ...
Authors:Ishchenko, A, Stauch, B, Han, G.W, Batyuk, A, Shiriaeva, A, Li, C, Zatsepin, N.A, Weierstall, U, Liu, W, Nango, E, Nakane, T, Tanaka, R, Tono, K, Joti, Y, Iwata, S, Moraes, I, Gati, C, Cherezov, C.
Deposit date:2019-07-12
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
Iucrj, 6, 2019
3CAP
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BU of 3cap by Molmil
Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State
Descriptor: 2-O-octyl-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, ...
Authors:Park, J.H, Scheerer, P, Hofmann, K.P, Choe, H.-W, Ernst, O.P.
Deposit date:2008-02-20
Release date:2008-06-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the ligand-free G-protein-coupled receptor opsin
Nature, 454, 2008
3EML
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BU of 3eml by Molmil
The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.
Descriptor: 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Human Adenosine A2A receptor/T4 lysozyme chimera, STEARIC ACID, ...
Authors:Jaakola, V.-P, Griffith, M.T, Hanson, M.A, Cherezov, V, Chien, E.Y.T, Lane, J.R, Ijzerman, A.P, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2008-09-24
Release date:2008-10-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist.
Science, 322, 2008
2RH1
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BU of 2rh1 by Molmil
High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, ACETAMIDE, ...
Authors:Cherezov, V, Rosenbaum, D.M, Hanson, M.A, Rasmussen, S.G.F, Thian, F.S, Kobilka, T.S, Choi, H.J, Kuhn, P, Weis, W.I, Kobilka, B.K, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2007-10-05
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Science, 318, 2007
3DQB
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BU of 3dqb by Molmil
Crystal structure of the active G-protein-coupled receptor opsin in complex with a C-terminal peptide derived from the Galpha subunit of transducin
Descriptor: 11meric peptide form Guanine nucleotide-binding protein G(t) subunit alpha-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, ...
Authors:Scheerer, P, Park, J.H, Hildebrand, P.W, Kim, Y.J, Krauss, N, Choe, H.-W, Hofmann, K.P, Ernst, O.P.
Deposit date:2008-07-09
Release date:2008-09-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of opsin in its G-protein-interacting conformation
Nature, 455, 2008
3D4S
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BU of 3d4s by Molmil
Cholesterol bound form of human beta2 adrenergic receptor.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol, Beta-2 adrenergic receptor/T4-lysozyme chimera, ...
Authors:Hanson, M.A, Cherezov, V, Roth, C.B, Griffith, M.T, Jaakola, V.-P, Chien, E.Y.T, Velasquez, J, Kuhn, P, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2008-05-14
Release date:2008-06-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.
Structure, 16, 2008
2X72
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BU of 2x72 by Molmil
CRYSTAL STRUCTURE OF THE CONSTITUTIVELY ACTIVE E113Q,D2C,D282C RHODOPSIN MUTANT WITH BOUND GALPHACT PEPTIDE.
Descriptor: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, ACETATE ION, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
Authors:Standfuss, J, Edwards, P.C, Dantona, A, Fransen, M, Xie, G, Oprian, D.D, Schertler, G.F.X.
Deposit date:2010-02-22
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Structural Basis of Agonist Induced Activation in Constitutively Active Rhodopsin
Nature, 471, 2011
5GLH
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BU of 5glh by Molmil
Human endothelin receptor type-B in complex with ET-1
Descriptor: Endothelin Receptor Subtype-B, Peptide from Endothelin-1
Authors:Shihoya, W, Nishizawa, T, Okuta, A, Tani, K, Fujiyoshi, Y, Dohmae, N, Nureki, O, Doi, T.
Deposit date:2016-07-11
Release date:2016-09-07
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Activation mechanism of endothelin ETB receptor by endothelin-1.
Nature, 537, 2016
6WH4
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BU of 6wh4 by Molmil
Crystal structure of HTR2A with inverse agonist
Descriptor: 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 fusion, CHOLESTEROL, ...
Authors:Kim, K.L, Che, T, Krumm, B.E, Roth, B.L.
Deposit date:2020-04-07
Release date:2020-09-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
6WWZ
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BU of 6wwz by Molmil
Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein
Descriptor: C-C chemokine receptor type 6,C-C chemokine receptor type 6, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wasilko, D.J, Johnson, Z.L, Ammirati, M, Han, S, Wu, H.
Deposit date:2020-05-09
Release date:2020-06-24
Last modified:2020-07-01
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20.
Nat Commun, 11, 2020
2HPY
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BU of 2hpy by Molmil
Crystallographic model of lumirhodopsin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
Authors:Nakamichi, H, Okada, T.
Deposit date:2006-07-18
Release date:2006-08-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Local peptide movement in the photoreaction intermediate of rhodopsin
Proc.Natl.Acad.Sci.Usa, 103, 2006
5GLI
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BU of 5gli by Molmil
Human endothelin receptor type-B in the ligand-free form
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Endothelin Receptor Subtype-B, OLEIC ACID, ...
Authors:Shihoya, W, Nishizawa, T, Okuta, A, Tani, K, Fujiyoshi, Y, Dohmae, N, Nureki, O, Doi, T.
Deposit date:2016-07-11
Release date:2016-09-07
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Activation mechanism of endothelin ETB receptor by endothelin-1.
Nature, 537, 2016
2I36
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BU of 2i36 by Molmil
Crystal structure of trigonal crystal form of ground-state rhodopsin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, Rhodopsin, ...
Authors:Stenkamp, R.E, Le Trong, I, Lodowski, D.T, Salom, D, Palczewski, K.
Deposit date:2006-08-17
Release date:2006-10-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2I37
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BU of 2i37 by Molmil
Crystal structure of a photoactivated rhodopsin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Rhodopsin, ...
Authors:Lodowski, D.T, Stenkamp, R.E, Salom, D, Le Trong, I, Palczewski, K.
Deposit date:2006-08-17
Release date:2006-10-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (4.15 Å)
Cite:Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.
Proc.Natl.Acad.Sci.Usa, 103, 2006

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数据于2024-09-18公开中

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