5XPR
Human endothelin receptor type-B in complex with antagonist bosentan
Summary for 5XPR
Entry DOI | 10.2210/pdb5xpr/pdb |
Descriptor | Endothelin B receptor,Endolysin,Endothelin B receptor, 4-tert-butyl-N-[6-(2-hydroxyethyloxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]benzenesulfonamide, SULFATE ION (3 entities in total) |
Functional Keywords | alpha helical, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein: P24530 |
Total number of polymer chains | 1 |
Total formula weight | 53063.96 |
Authors | Shihoya, W.,Nishizawa, T.,Yamashita, K.,Hirata, K.,Okuta, A.,Tani, K.,Fujiyoshi, Y.,Doi, T.,Nureki, O. (deposition date: 2017-06-04, release date: 2017-08-16, Last modification date: 2017-11-15) |
Primary citation | Shihoya, W.,Nishizawa, T.,Yamashita, K.,Inoue, A.,Hirata, K.,Kadji, F.M.N.,Okuta, A.,Tani, K.,Aoki, J.,Fujiyoshi, Y.,Doi, T.,Nureki, O. X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog Nat. Struct. Mol. Biol., 24:758-764, 2017 Cited by PubMed: 28805809DOI: 10.1038/nsmb.3450 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
Download full validation report