5XPR
Human endothelin receptor type-B in complex with antagonist bosentan
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Endothelin B receptor,Endolysin,Endothelin B receptor | polymer | 464 | 52128.1 | 1 | UniProt (P24530) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB | Homo sapiens (Human) | ET-BR,Endothelin receptor non-selective type,Lysis protein,Lysozyme,Muramidase |
2 | A | 4-tert-butyl-N-[6-(2-hydroxyethyloxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]benzenesulfonamide | non-polymer | 551.6 | 1 | Chemie (K86) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) |
Sequence modifications
A: 66 - 303 (UniProt: P24530)
A: 1018 - 1118 (UniProt: P00720)
A: 311 - 407 (UniProt: P24530)
PDB | External Database | Details |
---|---|---|
Gly 63 | - | expression tag |
Gly 64 | - | expression tag |
Gly 65 | - | expression tag |
Tyr 124 | Arg 124 | engineered mutation |
Ala 270 | Lys 270 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 1054 | Cys 97 | engineered mutation |
Arg 1094 | Ile 137 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asn 1002 | - | linker |
Ile 1003 | - | linker |
Phe 1004 | - | linker |
Glu 1005 | - | linker |
Met 1006 | - | linker |
Leu 1007 | - | linker |
Arg 1008 | - | linker |
Ile 1009 | - | linker |
Asp 1010 | - | linker |
Glu 1011 | - | linker |
Gly 1012 | - | linker |
Gly 1013 | - | linker |
Gly 1014 | - | linker |
Ser 1015 | - | linker |
Gly 1016 | - | linker |
Gly 1017 | - | linker |
Ala 342 | Ser 342 | engineered mutation |
Ala 381 | Ile 381 | engineered mutation |
Ala 396 | Cys 396 | engineered mutation |
Ala 400 | Cys 400 | engineered mutation |
Ala 405 | Cys 405 | engineered mutation |
Pro 408 | - | expression tag |
Ser 409 | - | expression tag |
Ser 410 | - | expression tag |
Glu 411 | - | expression tag |
Asn 412 | - | expression tag |
Leu 413 | - | expression tag |
Tyr 414 | - | expression tag |
Phe 415 | - | expression tag |
Gln 416 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 52128.1 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 935.9 | |
All* | Total formula weight | 53064.0 |