4V94
 
 | | Molecular architecture of the eukaryotic chaperonin TRiC/CCT derived by a combination of chemical crosslinking and mass-spectrometry, XL-MS | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | Authors: | Leitner, A, Joachimiak, L.A, Bracher, A, Walzthoeni, T, Chen, B, Monkemeyer, L, Pechmann, S, Holmes, S, Cong, Y, Ma, B, Ludtke, S, Chiu, W, Hartl, F.U, Aebersold, R, Frydman, J. | | Deposit date: | 2012-01-11 | | Release date: | 2014-07-09 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT.
Structure, 20, 2012
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7AZP
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5W79
 | | Crystal Structure of the Group II Chaperonin from Methanococcus Maripaludis, Cysteine-less mutant in the Apo State | | Descriptor: | Chaperonin, SULFATE ION | | Authors: | Dalton, K.M, Lopez, T, Liu, C, Ralston, C.Y, Pereira, J.H, Chartron, J.W, McAndrew, R.P, Douglas, N.R, Adams, P.D, Pande, V.S, Frydman, J. | | Deposit date: | 2017-06-19 | | Release date: | 2018-06-20 | | Last modified: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (3.122 Å) | | Cite: | The Conformational Cycle of the Group II Chaperonin Termini
To Be Published
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6QB8
 | | Human CCT:mLST8 complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | | Authors: | Cuellar, J, Santiago, C, Ludlam, W.G, Bueno-Carrasco, M.T, Valpuesta, J.M, Willardson, B.M. | | Deposit date: | 2018-12-20 | | Release date: | 2019-07-03 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.97 Å) | | Cite: | Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly.
Nat Commun, 10, 2019
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2NWC
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1XCK
 | | Crystal structure of apo GroEL | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 60 kDa chaperonin, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Bartolucci, C, Lamba, D, Grazulis, S, Manakova, E, Heumann, H. | | Deposit date: | 2004-09-02 | | Release date: | 2005-10-25 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.92 Å) | | Cite: | Crystal structure of wild-type chaperonin GroEL
J.Mol.Biol., 354, 2005
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3E76
 | | Crystal structure of Wild-type GroEL with bound Thallium ions | | Descriptor: | 60 kDa chaperonin, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Kiser, P.D, Lorimer, G.H, Palczewski, K. | | Deposit date: | 2008-08-17 | | Release date: | 2009-08-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.94 Å) | | Cite: | Use of thallium to identify monovalent cation binding sites in GroEL.
Acta Crystallogr.,Sect.F, 65, 2009
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4V8R
 | | The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | Authors: | Kalisman, N, Schroder, G.F, Levitt, M. | | Deposit date: | 2012-03-28 | | Release date: | 2014-07-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | The Crystal Structures of the Eukaryotic Chaperonin Cct Reveal its Functional Partitioning
Structure, 21, 2013
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5X9U
 | | Crystal structure of group III chaperonin in the open state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Thermosome, alpha subunit | | Authors: | An, Y.J, Cha, S.S. | | Deposit date: | 2017-03-09 | | Release date: | 2017-10-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (4.001 Å) | | Cite: | Structural and mechanistic characterization of an archaeal-like chaperonin from a thermophilic bacterium
Nat Commun, 8, 2017
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4WSC
 | | Crystal structure of a GroELK105A mutant | | Descriptor: | 60 kDa chaperonin | | Authors: | Lorimer, G.H, Ye, X, Fei, X, Yang, D, Corsepius, N, LaRonde, N.A. | | Deposit date: | 2014-10-26 | | Release date: | 2015-11-11 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.04 Å) | | Cite: | Crystal structure of a GroELK105A mutant
To Be Published
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5CDJ
 | | apical domain of chloroplast chaperonin 60a | | Descriptor: | RuBisCO large subunit-binding protein subunit alpha, chloroplastic | | Authors: | Zhang, S, Yu, F, Liu, C, Gao, F. | | Deposit date: | 2015-07-04 | | Release date: | 2016-07-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Functional Partition of Cpn60 alpha and Cpn60 beta Subunits in Substrate Recognition and Cooperation with Co-chaperonins
Mol Plant, 9, 2016
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6HDD
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5X9V
 | | Crystal structure of group III chaperonin in the Closed state | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Thermosome, ... | | Authors: | An, Y.J, Cha, S.S. | | Deposit date: | 2017-03-09 | | Release date: | 2017-10-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.003 Å) | | Cite: | Structural and mechanistic characterization of an archaeal-like chaperonin from a thermophilic bacterium
Nat Commun, 8, 2017
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3OSX
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6XHJ
 | | Cryo-EM structure of octadecameric TF55 (beta-only) complex from S. solfataricus bound to ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Thermosome subunit beta | | Authors: | Zeng, Y.C, Sobti, M, Stewart, A.G. | | Deposit date: | 2020-06-18 | | Release date: | 2021-03-17 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.62 Å) | | Cite: | Structural analysis of the Sulfolobus solfataricus TF55beta chaperonin by cryo-electron microscopy
Acta Crystallogr.,Sect.F, 77, 2021
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6XHI
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5DA8
 | | Crystal structure of chaperonin GroEL from | | Descriptor: | 60 kDa chaperonin, CALCIUM ION, MAGNESIUM ION, ... | | Authors: | Chang, C, Marshall, N, Feldmann, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2015-08-19 | | Release date: | 2015-10-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of chaperonin GroEL from
To Be Published
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5GW4
 | | Structure of Yeast NPP-TRiC | | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | | Authors: | Zang, Y, Jin, M, Wang, H, Cong, Y. | | Deposit date: | 2016-09-08 | | Release date: | 2016-10-26 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.
Nat. Struct. Mol. Biol., 23, 2016
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5OPW
 | | Crystal structure of the GroEL mutant A109C | | Descriptor: | 60 kDa chaperonin | | Authors: | Yan, X, Shi, Q, Bracher, A, Milicic, G, Singh, A.K, Hartl, F.U, Hayer-Hartl, M. | | Deposit date: | 2017-08-10 | | Release date: | 2018-01-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | GroEL Ring Separation and Exchange in the Chaperonin Reaction.
Cell, 172, 2018
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5GW5
 | | Structure of TRiC-AMP-PNP | | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | | Authors: | Zang, Y, Jin, M, Wang, H, Cong, Y. | | Deposit date: | 2016-09-08 | | Release date: | 2016-10-26 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.
Nat. Struct. Mol. Biol., 23, 2016
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4HEL
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7K3Z
 | | P. falciparum Cpn60 D474A mutant bound to ATP | | Descriptor: | 60 kDa chaperonin, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | Authors: | Tolia, N.H, Shi, D, Nguyen, B. | | Deposit date: | 2020-09-14 | | Release date: | 2021-04-21 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.69 Å) | | Cite: | Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding.
Sci Rep, 11, 2021
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4KI8
 | | Crystal structure of a GroEL-ADP complex in the relaxed allosteric state | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | | Authors: | Fei, X, Yang, D, LaRonde-LeBlanc, N, Lorimer, G.H. | | Deposit date: | 2013-05-01 | | Release date: | 2013-07-17 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.722 Å) | | Cite: | Crystal structure of a GroEL-ADP complex in the relaxed allosteric state at 2.7 A resolution.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3M6C
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9C0B
 | | E.coli GroEL + PBZ1587 inhibitor | | Descriptor: | 60 kDa chaperonin, N-(2-{4-[4-(aminomethyl)benzene-1-sulfonamido]phenyl}-1,3-benzoxazol-5-yl)-5-chlorothiophene-2-sulfonamide | | Authors: | Watson, E.R, Lander, G.C. | | Deposit date: | 2024-05-25 | | Release date: | 2024-08-07 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target.
J.Am.Chem.Soc., 146, 2024
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