8UIN
| Structure of the C3bBb-albicin complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, ... | 著者 | Andersen, J.F, Lei, H. | 登録日 | 2023-10-10 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM. Commun Biol, 7, 2024
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8UH2
| Complex of C3b with the inhibitor albicin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, Complement C3 beta chain, ... | 著者 | Andersen, J.F, Lei, H, Strayer, E, Ribeiro, J.M. | 登録日 | 2023-10-06 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | The mechanism of a mosquito salivary inhibitor of the alternative C3 convertase is elucidated through structural analysis of its complex with C3bBb To Be Published
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8OQ3
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8OVB
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8COE
| complement C5 in complex with the LCP0195 nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, Complement C5 beta chain, ... | 著者 | Andersen, G.R, Pedersen, D.V. | 登録日 | 2023-02-28 | 公開日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration. Mol.Immunol., 165, 2023
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8CML
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8EOK
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8ENU
| Structure of the C3bB proconvertase in complex with lufaxin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | 著者 | Andersen, J.F, Lei, H. | 登録日 | 2022-09-30 | 公開日 | 2023-08-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
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8CEM
| Structure of bovine native C3, re-refinement | 分子名称: | Complement C3 alpha chain, Complement C3 beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Andersen, G.R, Fredslund, F. | 登録日 | 2023-02-02 | 公開日 | 2023-04-05 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The structure of bovine complement component 3 reveals the basis for thioester function. J Mol Biol, 361, 2006
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7ZGK
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7ZGJ
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8B0H
| 2C9, C5b9-CD59 cryoEM structure | 分子名称: | CD59 glycoprotein, Complement C5, Complement component C6, ... | 著者 | Couves, E.C, Gardner, S, Bubeck, D. | 登録日 | 2022-09-07 | 公開日 | 2023-02-22 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
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8B0F
| CryoEM structure of C5b8-CD59 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Bubeck, D, Couves, E.C, Gardner, S. | 登録日 | 2022-09-07 | 公開日 | 2023-02-22 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
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8B0G
| 2C9, C5b9-CD59 structure | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 glycoprotein, Complement C5, ... | 著者 | Couves, E.C, Gardner, S, Bubeck, D. | 登録日 | 2022-09-07 | 公開日 | 2023-02-22 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
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8AYH
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7VON
| Native alpha-2-macroglobulin monomer | 分子名称: | Alpha-2-macroglobulin | 著者 | Huang, X, Wang, Y. | 登録日 | 2021-10-14 | 公開日 | 2022-11-16 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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7NOZ
| Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 alpha chain, Complement C3 beta chain, ... | 著者 | Lorenzen, J, Pedersen, D.V, Andersen, G.R. | 登録日 | 2021-02-26 | 公開日 | 2022-07-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging. Protein Sci., 31, 2022
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7Q1Y
| X-ray structure of human A2ML1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1, ... | 著者 | Andersen, G.R, Zarantonello, A, Enghild, J.J, Nielsen, N.S. | 登録日 | 2021-10-22 | 公開日 | 2022-04-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
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7O7L
| (h-alpha2M)4 native I | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-20 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7Q60
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7Q62
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7Q61
| Structure of TEV conjugated A2ML1 (A2ML1-TC) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1 | 著者 | Nielsen, N.S, Zarantonello, A, Andersen, G.R. | 登録日 | 2021-11-05 | 公開日 | 2022-04-20 | 最終更新日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
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7Q5Z
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7O7M
| (h-alpha2M)4 native II | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-13 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O7N
| (h-alpha2M)4 semiactivated I state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-13 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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