PDB: 46 件ウェブページステータス検索Chemie searchBIRD

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6XRO	Crystal structure of GlpG in complex with peptide boronate inhibitor, Ac-KRFRSMQYSA-B(OH)2 分子名称: CHLORIDE ION, Rhomboid protease GlpG, SODIUM ION, ... 著者 Urban, S, Cho, S. 登録日 2020-07-13 公開日 2020-09-16 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
4H1D	Cocrystal structure of GlpG and DFP 分子名称: DIISOPROPYL PHOSPHONATE, Rhomboid protease GlpG 著者 Xue, Y, Ha, Y. 登録日 2012-09-10 公開日 2013-05-01 最終更新日 2013-06-26 実験手法 X-RAY DIFFRACTION (2.8975 Å) 主引用文献 Large lateral movement of transmembrane helix s5 is not required for substrate access to the active site of rhomboid intramembrane protease. J.Biol.Chem., 288, 2013
3ODJ	Crystal structure of H. influenzae rhomboid GlpG with disordered loop 4, helix 5 and loop 5 分子名称: Rhomboid protease glpG 著者 Brooks, C.L, Lazareno-Saez, C, Lamoureux, J.S, Mak, M.W, Lemieux, M.J. 登録日 2010-08-11 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Insights into Substrate Gating in H. influenzae Rhomboid. J.Mol.Biol., 407, 2011
8AB5	Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl] 分子名称: Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl], Rhomboid protease GlpG 著者 Skerlova, J, Polovinkin, V, Bach, K, Borshchevskiy, V, Strisovsky, K. 登録日 2022-07-04 公開日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl] To Be Published
3B44	Crystal structure of GlpG W136A mutant 分子名称: glpG, nonyl beta-D-glucopyranoside 著者 Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. 登録日 2007-10-23 公開日 2008-01-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol., 374, 2007
3B45	Crystal structure of GlpG at 1.9A resolution 分子名称: glpG, nonyl beta-D-glucopyranoside 著者 Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. 登録日 2007-10-23 公開日 2008-01-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol., 374, 2007
4NJN	Crystal Structure of E.coli GlpG at pH 4.5 分子名称: Rhomboid protease GlpG 著者 Dickey, S.W, Baker, R.P, Cho, S, Urban, S. 登録日 2013-11-11 公開日 2013-12-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity. Cell(Cambridge,Mass.), 155, 2013
4NJP	Proteolysis inside the membrane is a rate-governed reaction not Driven by substrate affinity 分子名称: Rhomboid protease GlpG 著者 Dickey, S.W, Baker, R.P, Cho, S, Urban, S. 登録日 2013-11-11 公開日 2013-12-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity. Cell(Cambridge,Mass.), 155, 2013
2IRV	Crystal structure of GlpG, a rhomboid intramembrane serine protease 分子名称: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, DODECYL-BETA-D-MALTOSIDE, LAURYL DIMETHYLAMINE-N-OXIDE, ... 著者 Bibi, E, Fass, D, Ben-Shem, A. 登録日 2006-10-16 公開日 2006-10-31 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for intramembrane proteolysis by rhomboid serine proteases. Proc.Natl.Acad.Sci.Usa, 104, 2007
2IC8	Crystal structure of GlpG 分子名称: Protein glpG, nonyl beta-D-glucopyranoside 著者 Ha, Y. 登録日 2006-09-12 公開日 2006-10-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of a rhomboid family intramembrane protease. Nature, 444, 2006
6VJ8	Crystal structure of GlpG in complex with peptide chloromethylketone inhibitor 分子名称: Peptide chloromethylketone inhibitor, Rhomboid family intramembrane serine protease GlpG 著者 Urban, S, Cho, S. 登録日 2020-01-15 公開日 2020-09-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
6VJ9	Crystal structure of GlpG in complex with peptide boronate inhibitor 分子名称: ACE-VAL-ARG-MET-B2A, Rhomboid family intramembrane serine protease GlpG 著者 Urban, S, Cho, S. 登録日 2020-01-15 公開日 2020-09-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
2NRF	Crystal Structure of GlpG, a Rhomboid family intramembrane protease 分子名称: Protein GlpG 著者 Wu, Z, Yan, N, Feng, L, Yan, H, Gu, L, Shi, Y. 登録日 2006-11-02 公開日 2006-11-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat.Struct.Mol.Biol., 13, 2006
2NR9	Crystal structure of GlpG, Rhomboid Peptidase from Haemophilus influenzae 分子名称: (R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATE, 3,6,12,15,18,21,24-HEPTAOXAHEXATRIACONTAN-1-OL, Protein glpG homolog 著者 Lemieux, M.J, Fischer, S.J, Cherney, M.M, Bateman, K.S, James, M.N.G. 登録日 2006-11-01 公開日 2006-11-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis. Proc.Natl.Acad.Sci.USA, 104, 2007
2O7L	The open-cap conformation of GlpG 分子名称: Protein glpG, nonyl beta-D-glucopyranoside 著者 Ha, Y. 登録日 2006-12-11 公開日 2006-12-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Open-cap conformation of intramembrane protease GlpG. Proc.Natl.Acad.Sci.Usa, 104, 2007
6XRP	Crystal structure of GlpG in complex with peptide ketoamide inhibitor, Ac-RVWHA-ketoamide-phenylbutyl 分子名称: N-(4-phenylbutyl)formamide, Rhomboid protease GlpG, peptide ketoamide inhibitor 著者 Urban, S, Cho, S. 登録日 2020-07-13 公開日 2020-09-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
5MT7	Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-VRHA-cmk 分子名称: ACE-VAL-ARG-HIS-ALA-0QE, Rhomboid protease GlpG 著者 Vinothkumar, K.R. 登録日 2017-01-06 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
2XOW	Structure of GlpG in complex with a mechanism-based isocoumarin inhibitor 分子名称: 5-AMINO-2-(2-METHOXY-2-OXOETHYL)BENZOIC ACID, RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside 著者 Vinothkumar, K.R, Strisovsky, K, Andreeva, A, Christova, Y, Verhelst, S, Freeman, M. 登録日 2010-08-24 公開日 2010-10-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 The Structural Basis for Catalysis and Substrate Specificity of a Rhomboid Protease Embo J., 29, 2010
5MT6	Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-phenylethyl-ketoamide 分子名称: ACE-ARG-VAL-ARG-HIS-ALA-V9C, Rhomboid protease GlpG, nonyl beta-D-glucopyranoside 著者 Vinothkumar, K.R. 登録日 2017-01-06 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
2XOV	Crystal Structure of E.coli rhomboid protease GlpG, native enzyme 分子名称: GLYCEROL, RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside 著者 Vinothkumar, K.R, Strisovsky, K, Andreeva, A, Christova, Y, Verhelst, S, Freeman, M. 登録日 2010-08-24 公開日 2010-10-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 The structural basis for catalysis and substrate specificity of a rhomboid protease. EMBO J., 29, 2010
2XTU	Structure of E.coli rhomboid protease GlpG active site mutant, S201T in trigonal crystal form 分子名称: RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside 著者 Vinothkumar, K.R. 登録日 2010-10-12 公開日 2011-02-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of Rhomboid Protease in a Lipid Environment J.Mol.Biol., 407, 2011
5MT8	Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-cmk 分子名称: ACE-ARG-VAL-ARG-HIS-ALA-0QE, CHLORIDE ION, Rhomboid protease GlpG, ... 著者 Vinothkumar, K.R. 登録日 2017-01-06 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
5MTF	A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases 分子名称: CHLORIDE ION, Rhomboid protease GlpG, inhibitor, ... 著者 Ticha, A, Stanchev, S, Vinothkumar, K.R, Mikles, D.C, Pachl, P, Svehlova, K, Nguyen, M.T.N, Verhelst, S.H.L, Johnson, D, Bachovchin, D, Lepsik, M, Majer, P, Strisovsky, K. 登録日 2017-01-09 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
2XTV	Structure of E.coli rhomboid protease GlpG, active site mutant, S201T, orthorhombic crystal form 分子名称: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, RHOMBOID PROTEASE GLPG 著者 Vinothkumar, K.R. 登録日 2010-10-12 公開日 2011-02-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of rhomboid protease in a lipid environment. J. Mol. Biol., 407, 2011
5F5B	Structure of E.Coli GlpG complexed with peptidic inhibitor Ac-VRMA-CHO 分子名称: Rhomboid protease GlpG, peptidic derivative of Gurken: ACE-VAL-ARG-MET-ALA-aldehyde 著者 Urban, S, Cho, S, Dickey, S.W. 登録日 2015-12-04 公開日 2016-02-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016

 

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