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1A76
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FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
分子名称: FLAP ENDONUCLEASE-1 PROTEIN, MANGANESE (II) ION
著者Hwang, K.Y, Baek, K, Kim, H, Cho, Y.
登録日1998-03-20
公開日1999-08-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
1A77
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FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
分子名称: FLAP ENDONUCLEASE-1 PROTEIN, MAGNESIUM ION
著者Hwang, K.Y, Baek, K, Kim, H, Cho, Y.
登録日1998-03-20
公開日1999-08-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
1B43
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FEN-1 FROM P. FURIOSUS
分子名称: PROTEIN (FEN-1)
著者Hosfield, D.J, Mol, C.D, Shen, B, Tainer, J.A.
登録日1999-01-05
公開日2000-01-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Cell(Cambridge,Mass.), 95, 1998
1MC8
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Crystal Structure of Flap Endonuclease-1 R42E mutant from Pyrococcus horikoshii
分子名称: Flap Endonuclease-1
著者Matsui, E, Musti, K.V, Abe, J, Yamazaki, K, Matsui, I, Harata, K.
登録日2002-08-06
公開日2002-10-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Molecular Structure and Novel DNA Binding Sites Located in Loops of Flap Endonuclease-1 from Pyrococcus horikoshii
J.BIOL.CHEM., 277, 2002
1RXV
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Crystal Structure of A. Fulgidus FEN-1 bound to DNA
分子名称: 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG), Flap structure-specific endonuclease
著者Chapados, B.R, Hosfield, D.J, Han, S, Qiu, J, Yelent, B, Shen, B, Tainer, J.A.
登録日2003-12-18
公開日2004-01-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1RXW
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Crystal structure of A. fulgidus FEN-1 bound to DNA
分子名称: 5'-d(*C*pG*pA*pT*pG*pC*pT*pA)-3', 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG)-3', Flap structure-specific endonuclease
著者Chapados, B.R, Hosfield, D.J, Han, S, Qiu, J, Yelent, B, Shen, B, Tainer, J.A.
登録日2003-12-18
公開日2004-01-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1UL1
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Crystal structure of the human FEN1-PCNA complex
分子名称: Flap endonuclease-1, MAGNESIUM ION, Proliferating cell nuclear antigen
著者Sakurai, S, Kitano, K, Yamaguchi, H, Hamada, K, Okada, K, Fukuda, K, Uchida, M, Ohtsuka, E, Morioka, H, Hakoshima, T.
登録日2003-09-05
公開日2005-03-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for recruitment of human flap endonuclease 1 to PCNA
EMBO J., 24, 2005
2IZO
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Structure of an Archaeal PCNA1-PCNA2-FEN1 Complex
分子名称: DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE, ...
著者Dore, A.S, Kilkenny, M.L, Roe, S.M, Pearl, L.H.
登録日2006-07-25
公開日2006-09-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of an Archaeal PCNA1-PCNA2-Fen1 Complex: Elucidating PCNA Subunit and Client Enzyme Specificity.
Nucleic Acids Res., 34, 2006
3ORY
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Crystal structure of Flap endonuclease 1 from hyperthermophilic archaeon Desulfurococcus amylolyticus
分子名称: PHOSPHATE ION, flap endonuclease 1
著者Mase, T, Kubota, K, Miyazono, K, Kawarabayashii, Y, Tanokura, M.
登録日2010-09-08
公開日2011-02-09
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus
Acta Crystallogr.,Sect.F, 67, 2011
3Q8K
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Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with product 5'-flap DNA, SM3+, and K+
分子名称: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
著者Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A.
登録日2011-01-06
公開日2011-04-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2001 Å)
主引用文献Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
3Q8L
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Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with substrate 5'-flap DNA, SM3+, and K+
分子名称: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
著者Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A.
登録日2011-01-06
公開日2011-04-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.319 Å)
主引用文献Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
3Q8M
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Crystal Structure of Human Flap Endonuclease FEN1 (D181A) in complex with substrate 5'-flap DNA and K+
分子名称: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
著者Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A.
登録日2011-01-06
公開日2011-04-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
3QE9
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Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with DNA (complex I)
分子名称: CALCIUM ION, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
著者Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S.
登録日2011-01-20
公開日2011-04-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
3QEA
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Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA (complex II)
分子名称: BARIUM ION, DNA (5'-D(P*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
著者Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S.
登録日2011-01-20
公開日2011-04-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
3QEB
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Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA and Mn2+ (complex III)
分子名称: DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ...
著者Orans, J, McSweeney, E.A, Iyer, R.R, Hast, M.A, Hellinga, H.W, Modrich, P, Beese, L.S.
登録日2011-01-20
公開日2011-04-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
4Q0R
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The catalytic core of Rad2 (complex I)
分子名称: DNA (5'-D(*CP*TP*GP*AP*GP*TP*CP*AP*GP*AP*GP*CP*AP*AP*A)-3'), DNA repair protein RAD2
著者Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M.
登録日2014-04-02
公開日2014-08-27
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4Q0W
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he catalytic core of Rad2 in complex with DNA substrate (complex II)
分子名称: CALCIUM ION, DNA (5'-D(*TP*TP*AP*GP*GP*TP*GP*GP*AP*CP*GP*GP*AP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*GP*AP*TP*CP*CP*GP*TP*CP*CP*AP*CP*CP*TP*TP*T)-3'), ...
著者Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M.
登録日2014-04-02
公開日2014-08-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4Q0Z
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The catalytic core of Rad2 in complex with DNA substrate (complex III)
分子名称: CALCIUM ION, DNA (5'-D(*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*T)-3'), ...
著者Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M.
登録日2014-04-02
公開日2014-08-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.398 Å)
主引用文献Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4Q10
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The catalytic core of Rad2 in complex with DNA substrate (complex IV)
分子名称: CALCIUM ION, DNA (5'-D(*TP*TP*TP*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*TP*TP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*TP*TP*TP*T)-3'), ...
著者Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M.
登録日2014-04-02
公開日2014-08-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4WA8
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Methanopyrus Kandleri FEN-1 nuclease
分子名称: CHLORIDE ION, Flap endonuclease 1
著者Shah, S, Dunten, P, Horton, N.C.
登録日2014-08-28
公開日2014-11-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure and specificity of FEN-1 from Methanopyrus kandleri.
Proteins, 83, 2015
5CNQ
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Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA, Mg2+ and Mn2+ ions
分子名称: DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MANGANESE (II) ION, Nuclease-like protein, ...
著者Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J.
登録日2015-07-17
公開日2015-12-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.602 Å)
主引用文献Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.
Cell Rep, 13, 2015
5CO8
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Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA and Mg2+ ion
分子名称: DNA (31-MER), DNA (5'-D(*AP*GP*AP*CP*TP*GP*CP*AP*GP*TP*TP*GP*AP*GP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*A)-3'), ...
著者Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J.
登録日2015-07-20
公開日2016-01-13
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.
Cell Rep, 13, 2015
5FV7
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Human Fen1 in complex with an N-hydroxyurea compound
分子名称: 1-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, FLAP ENDONUCLEASE 1, MAGNESIUM ION
著者Exell, J.C, Thompson, M.J, Finger, L.D, Shaw, S.K, Abbott, W.M, McWhirter, C, Debreczeni, J.E, Jones, C.D, Nissink, J.W.M, Ward, T.A, Sioberg, C.W.L, Molina, D.M, Durant, S.T, Grasby, J.A.
登録日2016-02-03
公開日2016-08-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Cellular Active N-Hydroxyurea Fen1 Inhibitors Block Substrate Entry to the Active Site
Nat.Chem.Biol., 12, 2016
5K97
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Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+
分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), ...
著者Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
登録日2016-05-31
公開日2017-06-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
5KSE
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Flap endonuclease 1 (FEN1) R100A with 5'-flap substrate DNA and Sm3+
分子名称: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*AP*AP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
著者Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
登録日2016-07-08
公開日2017-06-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.105 Å)
主引用文献Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017

 

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