3QEB

Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA and Mn2+ (complex III)

Summary for 3QEB

• Entry DOI: 10.2210/pdb3qeb/pdb
• Related: 3QE9 3QEA
• Descriptor: Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ... (5 entities in total)
• Functional Keywords: exonuclease, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9UQ84
• Total number of polymer chains: 3
• Total formula weight: 46666.38

Authors

Orans, J.,McSweeney, E.A.,Iyer, R.R.,Hast, M.A.,Hellinga, H.W.,Modrich, P.,Beese, L.S. (deposition date: 2011-01-20, release date: 2011-04-20, Last modification date: 2024-02-21)

• Primary citation: Orans, J.,McSweeney, E.A.,Iyer, R.R.,Hast, M.A.,Hellinga, H.W.,Modrich, P.,Beese, L.S.; Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.; Cell(Cambridge,Mass.), 145:212-223, 2011; PubMed: 21496642; DOI: 10.1016/j.cell.2011.03.005

Experimental method

X-RAY DIFFRACTION (3 Å)