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6Q62
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BU of 6q62 by Molmil
Xanthomonas albilineans Dihydropteroate synthase in complex with (indole-2-carboxylic acid) and (6-chloroguanine)
Descriptor: 1,2-ETHANEDIOL, 1H-indole-2-carboxylic acid, 6-chloroguanine, ...
Authors:Oliveira, A.A, Hyvonen, M, Guido, R.V.C.
Deposit date:2018-12-10
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Xanthomonas albilineans Dihydropteroate synthase in complex with (indole-2-carboxylic acid) and (6-chloroguanine)
To Be Published
5JQ9
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BU of 5jq9 by Molmil
Yersinia pestis DHPS with pterine-sulfa conjugate Compound 16
Descriptor: 1,2-ETHANEDIOL, 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide, Dihydropteroate synthase
Authors:Wu, Y, White, S.W.
Deposit date:2016-05-04
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.
Bioorg.Med.Chem.Lett., 26, 2016
2OGY
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BU of 2ogy by Molmil
Asn199Ala Mutant of the 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.3 Angstrom resolution
Descriptor: 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase, CALCIUM ION
Authors:Doukov, T.I, Drennan, C.L, Hemmi, H, Ragsdale, S.W.
Deposit date:2007-01-09
Release date:2007-01-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases.
J.Biol.Chem., 282, 2007
1EYE
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BU of 1eye by Molmil
1.7 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTEROATE SYNTHASE (DHPS) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 6-HYDROXYMETHYLPTERIN MONOPHOSPHATE
Descriptor: DIHYDROPTEROATE SYNTHASE I, MAGNESIUM ION, PTERIN-6-YL-METHYL-MONOPHOSPHATE
Authors:Baca, A.M, Sirawaraporn, R, Turley, S, Sirawaraporn, W, Hol, W.G.J.
Deposit date:2000-05-05
Release date:2000-10-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action.
J.Mol.Biol., 302, 2000
6OMZ
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BU of 6omz by Molmil
Crystal Structure of Dihydropteroate synthase from Mycobacterium smegmatis with bound 6-hydroxymethylpterin-monophosphate
Descriptor: 1,2-ETHANEDIOL, CITRIC ACID, DIMETHYL SULFOXIDE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-04-19
Release date:2019-05-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Dihydropteroate synthase from Mycobacterium smegmatis with bound 6-hydroxymethylpterin-monophosphate
to be published
6OFW
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BU of 6ofw by Molmil
Dihydropteroate synthase from Xanthomonas albilineans in complex with 7,8-dihydropteroate
Descriptor: 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoic acid, Dihydropteroate synthase, SULFATE ION
Authors:Oliveira, A.A, Guido, R.V.C, Maluf, F.V, Bueno, R.V, Lima, G.M.A.
Deposit date:2019-04-01
Release date:2020-04-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Dihydropteroate synthase from Xanthomonas albilineans in complex with 7,8-dihydropteroate
To Be Published
7L6P
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BU of 7l6p by Molmil
Crystal structure of dihydropteroate synthase from Stenotrophomonas maltophilia with active site-bound imidazole
Descriptor: Dihydropteroate synthase, IMIDAZOLE
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-12-23
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of dihydropteroate synthase from Stenotrophomonas maltophilia with active site-bound imidazole
to be published
1F6Y
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BU of 1f6y by Molmil
MAD CRYSTAL STRUCTURE ANALYSIS OF METHYLTETRAHYDROFOLATE: CORRINOID/IRON-SULFUR PROTEIN METHYLTRANSFERASE (METR)
Descriptor: 5-METHYLTETRAHYDROFOLATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE
Authors:Doukov, T.I, Seravalli, J, Stezowski, J.J, Ragsdale, S.W.
Deposit date:2000-06-23
Release date:2000-08-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase.
Structure Fold.Des., 8, 2000
4D8Z
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BU of 4d8z by Molmil
Crystal structure of B. anthracis DHPS with compound 24
Descriptor: (3R)-3-(7-amino-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)butanoic acid, Dihydropteroate Synthase, SULFATE ION
Authors:Hammoudeh, D, Lee, R.E, White, S.W.
Deposit date:2012-01-11
Release date:2012-03-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity.
Chemmedchem, 7, 2012
6CLU
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BU of 6clu by Molmil
Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure
Descriptor: Dihydropteroate synthase
Authors:Gajewski, S, Griffith, E.C, Wu, Y, White, S.W.
Deposit date:2018-03-02
Release date:2018-08-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase.
Front Microbiol, 9, 2018
4D9P
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BU of 4d9p by Molmil
Crystal structure of B. anthracis DHPS with compound 17
Descriptor: (3R)-3-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)butanoic acid, Dihydropteroate Synthase, SULFATE ION
Authors:Hammoudeh, D, Lee, R.E, White, S.W.
Deposit date:2012-01-11
Release date:2012-03-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity.
Chemmedchem, 7, 2012
4D8A
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BU of 4d8a by Molmil
Crystal structure of B. anthracis DHPS with compound 21
Descriptor: Dihydropteroate synthase, LYSINE, SULFATE ION, ...
Authors:Hammoudeh, D, Lee, R.E, White, S.W.
Deposit date:2012-01-10
Release date:2012-04-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.183 Å)
Cite:Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity.
Chemmedchem, 7, 2012
6CLV
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BU of 6clv by Molmil
Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure
Descriptor: 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide, Dihydropteroate synthase
Authors:Gajewski, S, Griffith, E.C, Wu, Y, White, S.W.
Deposit date:2018-03-02
Release date:2018-08-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase.
Front Microbiol, 9, 2018
6DAY
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BU of 6day by Molmil
Xanthomonas albilineans Dihydropteroate synthase with 4-aminobenzoic acid at 1.65 A
Descriptor: 4-AMINOBENZOIC ACID, Dihydropteroate synthase, GLYCEROL, ...
Authors:Oliveira, A.A, Guido, R.V.C, Lima, G.M.A, Bueno, R.V, Maluf, F.V.
Deposit date:2018-05-02
Release date:2018-06-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Xanthomonas albilineans Dihydropteroate synthase with 4-aminobenzoic acid
To Be Published
2VEG
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BU of 2veg by Molmil
Dihydropteroate synthase from Streptococcus pneumoniae: complex with 6-hydroxymethyl-7,8-dihydropterin monophosphate
Descriptor: DIHYDROPTEROATE SYNTHASE, PHOSPHATE ION, PTERIN-6-YL-METHYL-MONOPHOSPHATE
Authors:Derrick, J, Levy, C.
Deposit date:2007-10-24
Release date:2008-03-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dihydropteroate Synthase from Streptococcus Pneumoniae: Structure, Ligand Recognition and Mechanism of Sulfonamide Resistance.
Biochem.J., 412, 2008
8SCD
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BU of 8scd by Molmil
Crystal structure of sulfonamide resistance enzyme Sul3 in complex with reaction intermediate
Descriptor: 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, 4-AMINOBENZOIC ACID, CHLORIDE ION, ...
Authors:Stogios, P.J, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2023-04-05
Release date:2023-05-03
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
Nat Commun, 14, 2023
2VP8
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BU of 2vp8 by Molmil
Structure of Mycobacterium tuberculosis Rv1207
Descriptor: 1,2-ETHANEDIOL, DIHYDROPTEROATE SYNTHASE 2
Authors:Gengenbacher, M, Xu, T, Niyomwattanakit, P, Spraggon, G, Dick, T.
Deposit date:2008-02-27
Release date:2008-08-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Biochemical and Structural Characterization of the Putative Dihydropteroate Synthase Ortholog Rv1207 of Mycobacterium Tuberculosis.
Fems Microbiol.Lett., 287, 2008
2VEF
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BU of 2vef by Molmil
Dihydropteroate synthase from Streptococcus pneumoniae
Descriptor: DIHYDROPTEROATE SYNTHASE, PHOSPHATE ION
Authors:Derrick, J.P, Levy, C.
Deposit date:2007-10-24
Release date:2008-03-25
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dihydropteroate Synthase from Streptococcus Pneumoniae: Structure, Ligand Recognition and Mechanism of Sulfonamide Resistance.
Biochem.J., 412, 2008
1AJZ
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BU of 1ajz by Molmil
STRUCTURE OF DIHYDROPTEROATE PYROPHOSPHORYLASE
Descriptor: DIHYDROPTEROATE SYNTHASE, SULFATE ION
Authors:Achari, A, Somers, D.O, Champness, J.N, Bryant, P.K, Rosemond, J, Stammers, D.K.
Deposit date:1997-05-13
Release date:1998-05-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.
Nat.Struct.Biol., 4, 1997
1AJ2
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BU of 1aj2 by Molmil
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE
Descriptor: DIHYDROPTEROATE SYNTHASE, SULFATE ION, [7,8-DIHYDRO-PTERIN-6-YL METHANYL]-PHOSPHONOPHOSPHATE
Authors:Achari, A, Somers, D.O, Champness, J.N, Bryant, P.K, Rosemond, J, Stammers, D.K.
Deposit date:1997-05-14
Release date:1998-05-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.
Nat.Struct.Biol., 4, 1997
1TX0
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BU of 1tx0 by Molmil
Dihydropteroate Synthetase, With Bound Product Analogue Pteroic Acid, From Bacillus anthracis
Descriptor: DHPS, Dihydropteroate synthase, PTEROIC ACID, ...
Authors:Babaoglu, K, Qi, J, Lee, R.E, White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TWZ
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BU of 1twz by Molmil
Dihydropteroate Synthetase, With Bound Substrate Analogue PtP, From Bacillus anthracis
Descriptor: DHPS, Dihydropteroate synthase, PTERIN-6-YL-METHYL-MONOPHOSPHATE, ...
Authors:Babaoglu, K, Qi, J, Lee, R.L, White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TWS
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BU of 1tws by Molmil
Dihydropteroate Synthetase From Bacillus anthracis
Descriptor: DHPS, Dihydropteroate synthase, SULFATE ION
Authors:Babaoglu, K, Qi, J, Lee, R.E, White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TX2
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BU of 1tx2 by Molmil
Dihydropteroate Synthetase, With Bound Inhibitor MANIC, From Bacillus anthracis
Descriptor: 6-METHYLAMINO-5-NITROISOCYTOSINE, DHPS, Dihydropteroate synthase, ...
Authors:Babaoglu, K, Qi, J, Lee, R.E, White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
2DZB
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BU of 2dzb by Molmil
Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in complex with 6HMPPP
Descriptor: 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, Dihydropteroate synthase
Authors:Bagautdinov, B, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-09-27
Release date:2007-03-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Dihydropteroate Synthase (FolP) from Thermus thermophilus HB8
To be Published

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