8E99
Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 59 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:36309015, ECO:0007744|PDB:8E93, ECO:0007744|PDB:8E97 |
| Chain | Residue | Details |
| D | VAL555-GLU575 | |
| D | ILE627-THR644 | |
| D | ASN814-GLU836 | |
| C | ALA649-GLU811 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:36309015 |
| Chain | Residue | Details |
| D | TYR576-THR598 | |
| D | ASN612-LYS626 | |
| A | ASN812-ILE835 | |
| C | SER560-LEU580 | |
| C | SER628-THR648 | |
| C | ASN812-ILE835 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:36309015, ECO:0007744|PDB:8E93, ECO:0007744|PDB:8E97 |
| Chain | Residue | Details |
| D | ILE599-PHE611 | |
| A | ASN616-PHE627 | |
| C | ASP581-SER604 | |
| C | ASN616-PHE627 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 168 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:36309015 |
| Chain | Residue | Details |
| D | ALA645-ASP813 | |
| C | SER605-LEU615 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00961 |
| Chain | Residue | Details |
| D | SER509 | |
| D | SER687 | |
| D | THR688 | |
| B | ASP282 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| D | THR511 | |
| D | ASP729 | |
| B | ARG518 | |
| B | SER689 | |
| B | THR690 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00959 |
| Chain | Residue | Details |
| D | ARG516 | |
| C | ARG523 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| D | ASN612 | |
| C | ASP732 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN70 | |
| D | ASN73 | |
| D | ASN438 | |
| D | ASN539 | |
| B | ASN541 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0007744|PDB:8E94, ECO:0007744|PDB:8E98 |
| Chain | Residue | Details |
| D | ASN337 | |
| C | ASN203 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0007744|PDB:8E92 |
| Chain | Residue | Details |
| D | ASN685 | |
| C | ASN239 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97, ECO:0007744|PDB:7EOQ |
| Chain | Residue | Details |
| A | ASN276 | |
| C | ASN276 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN300 | |
| A | ASN440 | |
| A | ASN491 | |
| A | ASN674 | |
| C | ASN300 | |
| C | ASN440 | |
| C | ASN491 | |
| C | ASN674 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97 |
| Chain | Residue | Details |
| A | ASN350 | |
| C | ASN350 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97 |
| Chain | Residue | Details |
| A | ASN368 | |
| C | ASN368 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0007744|PDB:7EOQ, ECO:0007744|PDB:7YFR |
| Chain | Residue | Details |
| A | ASN471 | |
| C | ASN471 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:34186027, ECO:0000269|PubMed:36309015, ECO:0000312|PDB:8E92, ECO:0000312|PDB:8E93, ECO:0000312|PDB:8E94, ECO:0000312|PDB:8E96, ECO:0000312|PDB:8E97, ECO:0000312|PDB:8E98, ECO:0000312|PDB:8E99, ECO:0007744|PDB:7EOQ |
| Chain | Residue | Details |
| A | ASN771 | |
| C | ASN771 |
