8E99
Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| D | VAL555-MET573 | |
| D | MET628-TYR643 | |
| D | MET815-ALA834 | |
| C | THR648-ASN812 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| D | PHE574-GLY600 | |
| D | ARG621-ILE627 | |
| A | MET813-ILE833 | |
| C | SER560-LEU580 | |
| C | ILE631-TYR647 | |
| C | MET813-ILE833 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| D | LYS601-PRO620 | |
| A | ARG625-ARG630 | |
| C | ASP581-THR602 | |
| C | ARG625-ARG630 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 170 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| D | THR644-ASN814 | |
| C | LEU603-PRO624 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00959 |
| Chain | Residue | Details |
| D | SER509 | |
| D | ARG516 | |
| D | SER687 | |
| B | ASP282 | |
| B | SER689 | |
| B | TYR730 | |
| C | SER688 | |
| C | ASP732 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| D | THR511 | |
| A | ASN491 | |
| A | ASN674 | |
| A | ASN771 | |
| C | ASN61 | |
| C | ASN203 | |
| C | ASN239 | |
| C | ASN276 | |
| C | ASN300 | |
| C | ASN350 | |
| C | ASN368 | |
| D | ASP729 | |
| C | ASN440 | |
| C | ASN471 | |
| C | ASN491 | |
| C | ASN674 | |
| C | ASN771 | |
| A | ASN239 | |
| A | ASN276 | |
| A | ASN300 | |
| A | ASN350 | |
| A | ASN368 | |
| A | ASN440 | |
| A | ASN471 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| D | ASN612 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN70 | |
| D | ASN73 | |
| D | ASN337 | |
| D | ASN438 | |
| D | ASN539 | |
| D | ASN685 | |
| B | ASN687 |
