Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7TJ8

Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001518	cellular_component	voltage-gated sodium channel complex
A	0005216	molecular_function	monoatomic ion channel activity
A	0005248	molecular_function	voltage-gated sodium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0007231	biological_process	osmosensory signaling pathway
A	0009617	biological_process	response to bacterium
A	0016020	cellular_component	membrane
A	0019725	biological_process	cellular homeostasis
A	0035725	biological_process	sodium ion transmembrane transport
A	0044325	molecular_function	transmembrane transporter binding
A	0055078	biological_process	sodium ion homeostasis
A	0055085	biological_process	transmembrane transport
A	0086002	biological_process	cardiac muscle cell action potential involved in contraction
A	0097386	cellular_component	glial cell projection
A	1990760	molecular_function	osmolarity-sensing monoatomic cation channel activity
B	0001518	cellular_component	voltage-gated sodium channel complex
B	0006814	biological_process	sodium ion transport
B	0017080	molecular_function	sodium channel regulator activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	133
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
B	PHE23-VAL156
A	LEU1203-SER1250
A	ARG1306-ILE1312
A	PRO1363-LEU1377
A	LYS1505-ILE1682
A	VAL168-ASP178
A	ASN220-LEU237
A	SER408-PRO505
A	HIS560-GLY568
A	TRP610-ALA626
A	SER733-ASN934
A	GLY991-ASN998
A	PHE1041-THR1055

site_id	SWS_FT_FI2
Number of Residues	21
Details	TRANSMEM: Helical => ECO:0000305\|PubMed:35301303, ECO:0007744\|PDB:7TJ8

Chain	Residue	Details
B	VAL157-ILE178

site_id	SWS_FT_FI3
Number of Residues	36
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
B	TYR179-GLU215
A	GLU1021
A	ALA1081-ASN1127
A	VAL1155-ILE1167
A	ASP1273-SER1276
A	LEU1339-PRO1341
A	ALA1403-PHE1420
A	ASN1445-ASN1468
A	SER197-ASP200
A	MET260-SER338
A	GLY367
A	LEU522-SER530
A	ALA587-MET592
A	PHE656-ASP673
A	GLY701
A	GLU954-ARG961

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN95
B	ASN109
B	ASN113
B	ASN121

site_id	SWS_FT_FI5
Number of Residues	17
Details	TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	PRO179-TYR196

site_id	SWS_FT_FI6
Number of Residues	18
Details	TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	PHE201-LEU219

site_id	SWS_FT_FI7
Number of Residues	21
Details	TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	ILE238-PHE259

site_id	SWS_FT_FI8
Number of Residues	102
Details	INTRAMEM: Pore-forming => ECO:0000250\|UniProtKB:D0E0C2

Chain	Residue	Details
A	PHE339-SER366
A	PHE674-ALA700
A	VAL1128-SER1154
A	GLY1421-PHE1444

site_id	SWS_FT_FI9
Number of Residues	39
Details	TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	LYS368-ILE407

site_id	SWS_FT_FI10
Number of Residues	15
Details	TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	PHE506-PHE521

site_id	SWS_FT_FI11
Number of Residues	28
Details	TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	LYS531-MET559

site_id	SWS_FT_FI12
Number of Residues	17
Details	TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	TRP569-LEU586

site_id	SWS_FT_FI13
Number of Residues	16
Details	TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	ALA593-TYR609

site_id	SWS_FT_FI14
Number of Residues	28
Details	TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	LEU627-GLU655

site_id	SWS_FT_FI15
Number of Residues	30
Details	TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	GLN702-SER732

site_id	SWS_FT_FI16
Number of Residues	18
Details	TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	TRP935-PHE953

site_id	SWS_FT_FI17
Number of Residues	28
Details	TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	LYS962-TYR990

site_id	SWS_FT_FI18
Number of Residues	21
Details	TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	GLY999-ARG1020

site_id	SWS_FT_FI19
Number of Residues	18
Details	TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	GLU1022-GLN1040

site_id	SWS_FT_FI20
Number of Residues	24
Details	TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	LEU1056-PHE1080

site_id	SWS_FT_FI21
Number of Residues	34
Details	TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	TYR1168-LYS1202

site_id	SWS_FT_FI22
Number of Residues	21
Details	TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	GLN1251-THR1272

site_id	SWS_FT_FI23
Number of Residues	28
Details	TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	LEU1277-PHE1305

site_id	SWS_FT_FI24
Number of Residues	25
Details	TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	ALA1313-TYR1338

site_id	SWS_FT_FI25
Number of Residues	20
Details	TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	PRO1342-GLY1362

site_id	SWS_FT_FI26
Number of Residues	24
Details	TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	PRO1378-PHE1402

site_id	SWS_FT_FI27
Number of Residues	35
Details	TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	PRO1469-LYS1504

site_id	SWS_FT_FI28
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000255

Chain	Residue	Details
A	SER442
A	SER869
A	SER905

site_id	SWS_FT_FI29
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKA => ECO:0000255

Chain	Residue	Details
A	THR777

site_id	SWS_FT_FI30
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER843

site_id	SWS_FT_FI31
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN276
A	ASN281
A	ASN1113

site_id	SWS_FT_FI32
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8

Chain	Residue	Details
A	ASN309

site_id	SWS_FT_FI33
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:35301303, ECO:0007744\|PDB:7TJ8, ECO:0007744\|PDB:7TJ9

Chain	Residue	Details
A	ASN1103

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)