7TJ8
Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium channel protein type 7 subunit alpha | polymer | 1737 | 199684.5 | 1 | UniProt (Q01118) Pfam (PF00520) Pfam (PF06512) | Homo sapiens (human) | Putative voltage-gated sodium channel subunit alpha Nax,Sodium channel protein cardiac and skeletal muscle subunit alpha,Sodium channel protein type VII subunit alpha |
| 2 | B (B) | Sodium channel subunit beta-3 | polymer | 215 | 24723.2 | 1 | UniProt (Q9NY72) Pfam (PF07686) | Homo sapiens (human) | |
| 3 | C, G, O (A) | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE | non-polymer | 720.0 | 3 | Chemie (PEV) | |||
| 4 | D, E, J (A) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 3 | Chemie (POV) | |||
| 5 | F, H, I, K, L... (A) | PALMITIC ACID | non-polymer | 256.4 | 6 | Chemie (PLM) | |||
| 6 | N, P, R, S, T (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 7 | Q (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
A: 1 - 1682 (UniProt: Q01118)
| PDB | External Database | Details |
|---|---|---|
| Met -54 | - | expression tag |
| Trp -53 | - | expression tag |
| Ser -52 | - | expression tag |
| His -51 | - | expression tag |
| Pro -50 | - | expression tag |
| Gln -49 | - | expression tag |
| Phe -48 | - | expression tag |
| Glu -47 | - | expression tag |
| Lys -46 | - | expression tag |
| Gly -45 | - | expression tag |
| Gly -44 | - | expression tag |
| Gly -43 | - | expression tag |
| Ser -42 | - | expression tag |
| Gly -41 | - | expression tag |
| Gly -40 | - | expression tag |
| Gly -39 | - | expression tag |
| Ser -38 | - | expression tag |
| Gly -37 | - | expression tag |
| Gly -36 | - | expression tag |
| Ser -35 | - | expression tag |
| Ala -34 | - | expression tag |
| Trp -33 | - | expression tag |
| Ser -32 | - | expression tag |
| His -31 | - | expression tag |
| Pro -30 | - | expression tag |
| Gln -29 | - | expression tag |
| Phe -28 | - | expression tag |
| Glu -27 | - | expression tag |
| Lys -26 | - | expression tag |
| Phe -25 | - | expression tag |
| Phe -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Phe -22 | - | expression tag |
| Phe -21 | - | expression tag |
| Asp -20 | - | expression tag |
| Tyr -19 | - | expression tag |
| Lys -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Lys -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 224407.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 7471.5 | |
| All* | Total formula weight | 231879.2 |
