7TJ8

Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs

Summary for 7TJ8

• Entry DOI: 10.2210/pdb7tj8/pdb
• EMDB information: 25919 25920
• Descriptor: Sodium channel protein type 7 subunit alpha, Sodium channel subunit beta-3, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ... (7 entities in total)
• Functional Keywords: sodium channel, nav, ion channel, metal transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 231879.18

Authors

Noland, C.L.,Kschonsak, M.,Ciferri, C.,Payandeh, J. (deposition date: 2022-01-14, release date: 2022-03-30)

• Primary citation: Noland, C.L.,Chua, H.C.,Kschonsak, M.,Heusser, S.A.,Braun, N.,Chang, T.,Tam, C.,Tang, J.,Arthur, C.P.,Ciferri, C.,Pless, S.A.,Payandeh, J.; Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel.; Nat Commun, 13:1416-1416, 2022; PubMed: 35301303; DOI: 10.1038/s41467-022-28984-4

Experimental method

ELECTRON MICROSCOPY (3.2 Å)