7CFT
Cryo-EM strucutre of human acid-sensing ion channel 1a in complex with snake toxin Mambalgin1 at pH 8.0
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005272 | molecular_function | sodium channel activity |
A | 0006814 | biological_process | sodium ion transport |
A | 0015280 | molecular_function | ligand-gated sodium channel activity |
A | 0016020 | cellular_component | membrane |
B | 0005272 | molecular_function | sodium channel activity |
B | 0006814 | biological_process | sodium ion transport |
B | 0015280 | molecular_function | ligand-gated sodium channel activity |
B | 0016020 | cellular_component | membrane |
C | 0005272 | molecular_function | sodium channel activity |
C | 0006814 | biological_process | sodium ion transport |
C | 0015280 | molecular_function | ligand-gated sodium channel activity |
C | 0016020 | cellular_component | membrane |
D | 0005576 | cellular_component | extracellular region |
D | 0035821 | biological_process | modulation of process of another organism |
D | 0090729 | molecular_function | toxin activity |
D | 0099106 | molecular_function | ion channel regulator activity |
E | 0005576 | cellular_component | extracellular region |
E | 0035821 | biological_process | modulation of process of another organism |
E | 0090729 | molecular_function | toxin activity |
E | 0099106 | molecular_function | ion channel regulator activity |
F | 0005576 | cellular_component | extracellular region |
F | 0035821 | biological_process | modulation of process of another organism |
F | 0090729 | molecular_function | toxin activity |
F | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PROSITE/UniProt
site_id | PS01206 |
Number of Residues | 21 |
Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
Chain | Residue | Details |
A | TYR305-CYS325 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | SITE: Important residue for inhibition of rat ASIC1a => ECO:0000269|PubMed:26680001 |
Chain | Residue | Details |
D | PHE27 | |
F | ARG28 | |
F | ILE33 | |
F | LEU34 | |
D | ARG28 | |
D | ILE33 | |
D | LEU34 | |
E | PHE27 | |
E | ARG28 | |
E | ILE33 | |
E | LEU34 | |
F | PHE27 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | SITE: Key residue for inhibition of rat ASIC1a, probably binds to rat ASIC1a F-350 => ECO:0000269|PubMed:26680001 |
Chain | Residue | Details |
D | LEU32 | |
E | LEU32 | |
F | LEU32 |
site_id | SWS_FT_FI3 |
Number of Residues | 1071 |
Details | TOPO_DOM: Extracellular => ECO:0000250 |
Chain | Residue | Details |
A | HIS70-GLU427 | |
B | HIS70-GLU427 | |
C | HIS70-GLU427 |
site_id | SWS_FT_FI4 |
Number of Residues | 78 |
Details | TRANSMEM: Discontinuously helical => ECO:0000250 |
Chain | Residue | Details |
A | ILE428-PHE454 | |
B | ILE428-PHE454 | |
C | ILE428-PHE454 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | SITE: Important for channel gating => ECO:0000250 |
Chain | Residue | Details |
A | TYR71 | |
A | TRP287 | |
B | TYR71 | |
B | TRP287 | |
C | TYR71 | |
C | TRP287 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | SITE: Important for channel desensitizing => ECO:0000250 |
Chain | Residue | Details |
A | GLU79 | |
B | GLU79 | |
C | GLU79 |
site_id | SWS_FT_FI7 |
Number of Residues | 3 |
Details | SITE: Important for interaction with the spider venom psalmotoxin-1 => ECO:0000269|PubMed:19654327 |
Chain | Residue | Details |
A | PHE352 | |
B | PHE352 | |
C | PHE352 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | SITE: Key residue for defining the pH sensitivity of ASIC1 (isoform 1) => ECO:0000269|PubMed:19654327 |
Chain | Residue | Details |
A | ASP357 | |
B | ASP357 | |
C | ASP357 |
site_id | SWS_FT_FI9 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN368 | |
A | ASN395 | |
B | ASN368 | |
B | ASN395 | |
C | ASN368 | |
C | ASN395 |