7CFT

Cryo-EM strucutre of human acid-sensing ion channel 1a in complex with snake toxin Mambalgin1 at pH 8.0

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Acid-sensing ion channel 1	polymer	477	54701.3	3	UniProt (P78348) Pfam (PF00858)	Homo sapiens (Human)	ASIC1,Amiloride-sensitive cation channel 2,neuronal,Brain sodium channel 2,BNaC2
2	D, E, F (D, E, F)	Mambalgin-1	polymer	57	6574.6	3	UniProt (P0DKR6) Pfam (PF21947)	Dendroaspis polylepis polylepis	Mamb-1,Pi-Dp1
3	G, H, I, J, K... (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)

Sequence modifications

A, B, C: 1 - 468 (UniProt: P78348)

PDB	External Database	Details
Met -8	-	initiating methionine
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	183827.8
Non-Polymers*	Number of molecules	6
	Total formula weight	1327.2
All*	Total formula weight	185155.1

*Water molecules are not included.