7CFT
Cryo-EM strucutre of human acid-sensing ion channel 1a in complex with snake toxin Mambalgin1 at pH 8.0
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Acid-sensing ion channel 1 | polymer | 477 | 54701.3 | 3 | UniProt (P78348) Pfam (PF00858) In PDB | Homo sapiens (Human) | ASIC1,Amiloride-sensitive cation channel 2,neuronal,Brain sodium channel 2,BNaC2 |
2 | D, E, F | Mambalgin-1 | polymer | 57 | 6574.6 | 3 | UniProt (P0DKR6) Pfam (PF21947) In PDB | Dendroaspis polylepis polylepis | Mamb-1,Pi-Dp1 |
3 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 468 (UniProt: P78348)
PDB | External Database | Details |
---|---|---|
Met -8 | - | initiating methionine |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 183827.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1327.2 | |
All* | Total formula weight | 185155.1 |