6ZQZ
[1,2,4]Triazolo[1,5-a]pyrimidine Phosphodiesterase 2 Inhibitors
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 1001 |
| Chain | Residue |
| A | HIS660 |
| A | HIS696 |
| A | ASP697 |
| A | ASP808 |
| A | HOH1200 |
| A | HOH1201 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1002 |
| Chain | Residue |
| A | HOH1183 |
| A | HOH1200 |
| A | HOH1214 |
| A | ASP697 |
| A | HOH1141 |
| A | HOH1165 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue QOQ A 1003 |
| Chain | Residue |
| A | TYR655 |
| A | LEU809 |
| A | ASP811 |
| A | GLN812 |
| A | ILE822 |
| A | ILE826 |
| A | TYR827 |
| A | MET847 |
| A | GLN859 |
| A | PHE862 |
| A | HOH1193 |
| D | HIS587 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 1001 |
| Chain | Residue |
| B | HIS660 |
| B | HIS696 |
| B | ASP697 |
| B | ASP808 |
| B | HOH1124 |
| B | HOH1215 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1002 |
| Chain | Residue |
| B | ASP697 |
| B | HOH1119 |
| B | HOH1124 |
| B | HOH1160 |
| B | HOH1166 |
| B | HOH1178 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue QOQ B 1003 |
| Chain | Residue |
| B | TYR655 |
| B | LEU809 |
| B | ASP811 |
| B | GLN812 |
| B | ILE822 |
| B | ILE826 |
| B | TYR827 |
| B | MET847 |
| B | GLN859 |
| B | PHE862 |
| B | ILE866 |
| B | HOH1203 |
| B | HOH1297 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1004 |
| Chain | Residue |
| B | HOH1103 |
| B | HOH1304 |
| B | HOH1308 |
| C | HOH1102 |
| C | HOH1144 |
| C | HOH1190 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue ZN C 1001 |
| Chain | Residue |
| C | HIS660 |
| C | HIS696 |
| C | ASP697 |
| C | ASP808 |
| C | HOH1105 |
| C | HOH1127 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 1002 |
| Chain | Residue |
| C | ASP697 |
| C | HOH1105 |
| C | HOH1135 |
| C | HOH1154 |
| C | HOH1171 |
| C | HOH1172 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for residue QOQ C 1003 |
| Chain | Residue |
| C | TYR655 |
| C | HIS656 |
| C | LEU809 |
| C | ASP811 |
| C | GLN812 |
| C | ILE822 |
| C | ILE826 |
| C | TYR827 |
| C | PHE830 |
| C | MET847 |
| C | GLN859 |
| C | PHE862 |
| C | HOH1158 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN D 1001 |
| Chain | Residue |
| D | HIS660 |
| D | HIS696 |
| D | ASP697 |
| D | ASP808 |
| D | MG1002 |
| D | HOH1119 |
| D | HOH1238 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue MG D 1002 |
| Chain | Residue |
| D | ASP697 |
| D | ZN1001 |
| D | HOH1119 |
| D | HOH1127 |
| D | HOH1138 |
| D | HOH1226 |
| D | HOH1252 |
| site_id | AD4 |
| Number of Residues | 12 |
| Details | binding site for residue QOQ D 1003 |
| Chain | Residue |
| D | ILE822 |
| D | ILE826 |
| D | TYR827 |
| D | MET847 |
| D | GLN859 |
| D | PHE862 |
| D | HOH1224 |
| A | GLN591 |
| D | TYR655 |
| D | LEU809 |
| D | ASP811 |
| D | GLN812 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF |
| Chain | Residue | Details |
| A | HIS696-PHE707 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083 |
| Chain | Residue | Details |
| A | HIS656 | |
| B | HIS656 | |
| C | HIS656 | |
| D | HIS656 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15938621, ECO:0000269|PubMed:19828435, ECO:0000269|PubMed:23899287, ECO:0007744|PDB:1Z1L, ECO:0007744|PDB:3IBJ, ECO:0007744|PDB:3ITM, ECO:0007744|PDB:3ITU, ECO:0007744|PDB:4HTX, ECO:0007744|PDB:4HTZ, ECO:0007744|PDB:4JIB |
| Chain | Residue | Details |
| A | HIS660 | |
| D | HIS660 | |
| D | ASP697 | |
| D | ASP808 | |
| A | ASP697 | |
| A | ASP808 | |
| B | HIS660 | |
| B | ASP697 | |
| B | ASP808 | |
| C | HIS660 | |
| C | ASP697 | |
| C | ASP808 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15938621, ECO:0000269|PubMed:19828435, ECO:0000269|PubMed:23899287, ECO:0007744|PDB:1Z1L, ECO:0007744|PDB:3ITM, ECO:0007744|PDB:3ITU, ECO:0007744|PDB:4HTX, ECO:0007744|PDB:4HTZ, ECO:0007744|PDB:4JIB |
| Chain | Residue | Details |
| A | HIS696 | |
| B | HIS696 | |
| C | HIS696 | |
| D | HIS696 |
