4HTX
Crystal structure of PDE2 catalytic domain in complex with BAY60-7550
Summary for 4HTX
Entry DOI | 10.2210/pdb4htx/pdb |
Related | 4HTZ |
Descriptor | cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform PDE2A3: Cell membrane ; Lipid-anchor . Isoform PDE2A2: Mitochondrion matrix . Isoform PDE2A1: Cytoplasm . Isoform 5: Mitochondrion : O00408 |
Total number of polymer chains | 4 |
Total formula weight | 162128.23 |
Authors | |
Primary citation | Zhu, J.,Yang, Q.,Dai, D.,Huang, Q. X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity. J.Am.Chem.Soc., 135:11708-11711, 2013 Cited by PubMed: 23899287DOI: 10.1021/ja404449g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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