6ZQZ
[1,2,4]Triazolo[1,5-a]pyrimidine Phosphodiesterase 2 Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cGMP-dependent 3',5'-cyclic phosphodiesterase | polymer | 353 | 41432.4 | 4 | UniProt (O00408) Pfam (PF00233) | Homo sapiens (Human) | Cyclic GMP-stimulated phosphodiesterase,cGSPDE |
| 2 | E, H, L, O (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, I, K, M, P (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 4 | G, J, N, Q (A, B, C, D) | 5-[bis(fluoranyl)methyl]-7-[(3~{S})-1-[(2-chloranyl-6-methyl-pyridin-4-yl)methyl]piperidin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidine | non-polymer | 392.8 | 4 | Chemie (QOQ) | |||
| 5 | R, S, T, U (A, B, C, D) | water | water | 18.0 | 910 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 578 - 921 (UniProt: O00408)
| PDB | External Database | Details |
|---|---|---|
| Met 576 | - | initiating methionine |
| Gly 577 | - | expression tag |
| Arg 922 | - | expression tag |
| His 923 | - | expression tag |
| His 924 | - | expression tag |
| His 925 | - | expression tag |
| His 926 | - | expression tag |
| His 927 | - | expression tag |
| His 928 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 165729.5 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1954.5 | |
| All* | Total formula weight | 167684.0 |
