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6N7H

Cryo-EM structure of the 2:1 hPtch1-Shhp complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001658biological_processbranching involved in ureteric bud morphogenesis
A0001701biological_processin utero embryonic development
A0001709biological_processcell fate determination
A0001841biological_processneural tube formation
A0001843biological_processneural tube closure
A0003007biological_processheart morphogenesis
A0005113molecular_functionpatched binding
A0005119molecular_functionsmoothened binding
A0005515molecular_functionprotein binding
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0005929cellular_componentcilium
A0007165biological_processsignal transduction
A0007224biological_processsmoothened signaling pathway
A0007286biological_processspermatid development
A0007346biological_processregulation of mitotic cell cycle
A0007389biological_processpattern specification process
A0007420biological_processbrain development
A0008158molecular_functionhedgehog receptor activity
A0008201molecular_functionheparin binding
A0008285biological_processnegative regulation of cell population proliferation
A0008544biological_processepidermis development
A0008589biological_processregulation of smoothened signaling pathway
A0009410biological_processresponse to xenobiotic stimulus
A0009612biological_processresponse to mechanical stimulus
A0009887biological_processanimal organ morphogenesis
A0009953biological_processdorsal/ventral pattern formation
A0009957biological_processepidermal cell fate specification
A0010157biological_processresponse to chlorate
A0010839biological_processnegative regulation of keratinocyte proliferation
A0010875biological_processpositive regulation of cholesterol efflux
A0014070biological_processresponse to organic cyclic compound
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0016485biological_processprotein processing
A0021522biological_processspinal cord motor neuron differentiation
A0021532biological_processneural tube patterning
A0021904biological_processdorsal/ventral neural tube patterning
A0021997biological_processneural plate axis specification
A0030326biological_processembryonic limb morphogenesis
A0030332molecular_functioncyclin binding
A0030496cellular_componentmidbody
A0030666cellular_componentendocytic vesicle membrane
A0030850biological_processprostate gland development
A0030879biological_processmammary gland development
A0032355biological_processresponse to estradiol
A0032526biological_processresponse to retinoic acid
A0032880biological_processregulation of protein localization
A0035108biological_processlimb morphogenesis
A0035137biological_processhindlimb morphogenesis
A0040008biological_processregulation of growth
A0040015biological_processnegative regulation of multicellular organism growth
A0042127biological_processregulation of cell population proliferation
A0042593biological_processglucose homeostasis
A0043231cellular_componentintracellular membrane-bounded organelle
A0043433biological_processnegative regulation of DNA-binding transcription factor activity
A0043616biological_processkeratinocyte proliferation
A0044294cellular_componentdendritic growth cone
A0044295cellular_componentaxonal growth cone
A0044877molecular_functionprotein-containing complex binding
A0045177cellular_componentapical part of cell
A0045606biological_processpositive regulation of epidermal cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045879biological_processnegative regulation of smoothened signaling pathway
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0048471cellular_componentperinuclear region of cytoplasm
A0048568biological_processembryonic organ development
A0048745biological_processsmooth muscle tissue development
A0050673biological_processepithelial cell proliferation
A0050680biological_processnegative regulation of epithelial cell proliferation
A0051782biological_processnegative regulation of cell division
A0060037biological_processpharyngeal system development
A0060170cellular_componentciliary membrane
A0060603biological_processmammary gland duct morphogenesis
A0060644biological_processmammary gland epithelial cell differentiation
A0061005biological_processcell differentiation involved in kidney development
A0061053biological_processsomite development
A0071397biological_processcellular response to cholesterol
A0071679biological_processcommissural neuron axon guidance
A0072089biological_processstem cell proliferation
A0072203biological_processcell proliferation involved in metanephros development
A0072205biological_processmetanephric collecting duct development
A0072659biological_processprotein localization to plasma membrane
A0097108molecular_functionhedgehog family protein binding
A0097421biological_processliver regeneration
A2000647biological_processnegative regulation of stem cell proliferation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001658biological_processbranching involved in ureteric bud morphogenesis
B0001701biological_processin utero embryonic development
B0001709biological_processcell fate determination
B0001841biological_processneural tube formation
B0001843biological_processneural tube closure
B0003007biological_processheart morphogenesis
B0005113molecular_functionpatched binding
B0005119molecular_functionsmoothened binding
B0005515molecular_functionprotein binding
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0005901cellular_componentcaveola
B0005929cellular_componentcilium
B0007165biological_processsignal transduction
B0007224biological_processsmoothened signaling pathway
B0007286biological_processspermatid development
B0007346biological_processregulation of mitotic cell cycle
B0007389biological_processpattern specification process
B0007420biological_processbrain development
B0008158molecular_functionhedgehog receptor activity
B0008201molecular_functionheparin binding
B0008285biological_processnegative regulation of cell population proliferation
B0008544biological_processepidermis development
B0008589biological_processregulation of smoothened signaling pathway
B0009410biological_processresponse to xenobiotic stimulus
B0009612biological_processresponse to mechanical stimulus
B0009887biological_processanimal organ morphogenesis
B0009953biological_processdorsal/ventral pattern formation
B0009957biological_processepidermal cell fate specification
B0010157biological_processresponse to chlorate
B0010839biological_processnegative regulation of keratinocyte proliferation
B0010875biological_processpositive regulation of cholesterol efflux
B0014070biological_processresponse to organic cyclic compound
B0015485molecular_functioncholesterol binding
B0016020cellular_componentmembrane
B0016485biological_processprotein processing
B0021522biological_processspinal cord motor neuron differentiation
B0021532biological_processneural tube patterning
B0021904biological_processdorsal/ventral neural tube patterning
B0021997biological_processneural plate axis specification
B0030326biological_processembryonic limb morphogenesis
B0030332molecular_functioncyclin binding
B0030496cellular_componentmidbody
B0030666cellular_componentendocytic vesicle membrane
B0030850biological_processprostate gland development
B0030879biological_processmammary gland development
B0032355biological_processresponse to estradiol
B0032526biological_processresponse to retinoic acid
B0032880biological_processregulation of protein localization
B0035108biological_processlimb morphogenesis
B0035137biological_processhindlimb morphogenesis
B0040008biological_processregulation of growth
B0040015biological_processnegative regulation of multicellular organism growth
B0042127biological_processregulation of cell population proliferation
B0042593biological_processglucose homeostasis
B0043231cellular_componentintracellular membrane-bounded organelle
B0043433biological_processnegative regulation of DNA-binding transcription factor activity
B0043616biological_processkeratinocyte proliferation
B0044294cellular_componentdendritic growth cone
B0044295cellular_componentaxonal growth cone
B0044877molecular_functionprotein-containing complex binding
B0045177cellular_componentapical part of cell
B0045606biological_processpositive regulation of epidermal cell differentiation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045879biological_processnegative regulation of smoothened signaling pathway
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0048471cellular_componentperinuclear region of cytoplasm
B0048568biological_processembryonic organ development
B0048745biological_processsmooth muscle tissue development
B0050673biological_processepithelial cell proliferation
B0050680biological_processnegative regulation of epithelial cell proliferation
B0051782biological_processnegative regulation of cell division
B0060037biological_processpharyngeal system development
B0060170cellular_componentciliary membrane
B0060603biological_processmammary gland duct morphogenesis
B0060644biological_processmammary gland epithelial cell differentiation
B0061005biological_processcell differentiation involved in kidney development
B0061053biological_processsomite development
B0071397biological_processcellular response to cholesterol
B0071679biological_processcommissural neuron axon guidance
B0072089biological_processstem cell proliferation
B0072203biological_processcell proliferation involved in metanephros development
B0072205biological_processmetanephric collecting duct development
B0072659biological_processprotein localization to plasma membrane
B0097108molecular_functionhedgehog family protein binding
B0097421biological_processliver regeneration
B2000647biological_processnegative regulation of stem cell proliferation
C0007267biological_processcell-cell signaling
C0007275biological_processmulticellular organism development
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBINDING: BINDING => ECO:0000269|PubMed:20504762, ECO:0007744|PDB:3MXW
ChainResidueDetails
CGLU89
BASP599-LYS748
BASN1049-ILE1055
BLEU1105-HIS1121
CGLU90
CASP95
CTHR125
CGLU126
CASP129
CASP131
BLEU458-ALA472
BSER523-SER547

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:10753901, ECO:0000269|PubMed:20504762, ECO:0007744|PDB:3M1N, ECO:0007744|PDB:3MXW
ChainResidueDetails
CHIS140
AVAL1084-PHE1104
AMET1122-ALA1141
AVAL1155-LEU1175
BPHE101-LEU121
BVAL437-MET457
BGLY473-ILE493
BVAL502-PHE522
BVAL548-PRO568
BALA578-MET598
BALA749-THR769
CASP147
BLEU1028-LEU1048
BILE1056-ILE1076
BVAL1084-PHE1104
BMET1122-ALA1141
BVAL1155-LEU1175
CHIS182
AVAL502-PHE522
AVAL548-PRO568
AALA578-MET598
AALA749-THR769
ALEU1028-LEU1048
AILE1056-ILE1076

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:Q02936
ChainResidueDetails
CGLY197
BARG770-TRP1027
BLYS1077-VAL1083
BGLY1142-ALA1154
ASER494-GLN501
AALA569-ALA577
AARG770-TRP1027
ALYS1077-VAL1083
AGLY1142-ALA1154
BGLU122-ASP436
BSER494-GLN501
BALA569-ALA577

site_idSWS_FT_FI4
Number of Residues1
DetailsLIPID: N-palmitoyl cysteine => ECO:0000269|PubMed:18534984, ECO:0000269|PubMed:31875564, ECO:0000269|PubMed:9593755
ChainResidueDetails
CCYS24
BTHR1195

site_idSWS_FT_FI5
Number of Residues1
DetailsLIPID: Cholesterol glycine ester => ECO:0000250|UniProtKB:Q62226
ChainResidueDetails
CGLY197
BSER1197

site_idSWS_FT_FI6
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN141
BASN414
BASN875
BASN1000
AASN312
AASN349
AASN414
AASN875
AASN1000
BASN141
BASN312
BASN349

219140

PDB entries from 2024-05-01

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