6N7H
Cryo-EM structure of the 2:1 hPtch1-Shhp complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protein patched homolog 1 | polymer | 1349 | 150189.6 | 2 | UniProt (Q13635) Pfam (PF02460) In PDB | Homo sapiens (Human) | PTC1 |
2 | C | Sonic hedgehog protein | polymer | 174 | 19594.0 | 1 | UniProt (Q15465) Pfam (PF01085) In PDB | Homo sapiens (Human) | SHH,HHG-1,Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC |
3 | D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
5 | A, B, C | CHOLESTEROL | non-polymer | 386.7 | 5 | Chemie (CLR) | |||
6 | C | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
7 | C | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
8 | C | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) |
Sequence modifications
A, B: 1 - 1305 (UniProt: Q13635)
PDB | External Database | Details |
---|---|---|
Met -20 | - | initiating methionine |
Ala -19 | - | expression tag |
Asp -18 | - | expression tag |
Tyr -17 | - | expression tag |
Lys -16 | - | expression tag |
Asp -15 | - | expression tag |
Asp -14 | - | expression tag |
Asp -13 | - | expression tag |
Asp -12 | - | expression tag |
Lys -11 | - | expression tag |
Ser -10 | - | expression tag |
Gly -9 | - | expression tag |
Pro -8 | - | expression tag |
Asp -7 | - | expression tag |
Glu -6 | - | expression tag |
Val -5 | - | expression tag |
Asp -4 | - | expression tag |
Ala -3 | - | expression tag |
Ser -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
Leu 1306 | - | expression tag |
Glu 1307 | - | expression tag |
Gly 1308 | - | expression tag |
Ser 1309 | - | expression tag |
Asp 1310 | - | expression tag |
Glu 1311 | - | expression tag |
Val 1312 | - | expression tag |
Asp 1313 | - | expression tag |
Ala 1314 | - | expression tag |
Val 1315 | - | expression tag |
Glu 1316 | - | expression tag |
Gly 1317 | - | expression tag |
Ser 1318 | - | expression tag |
His 1319 | - | expression tag |
His 1320 | - | expression tag |
His 1321 | - | expression tag |
His 1322 | - | expression tag |
His 1323 | - | expression tag |
His 1324 | - | expression tag |
His 1325 | - | expression tag |
His 1326 | - | expression tag |
His 1327 | - | expression tag |
His 1328 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 319973.2 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 4547.3 | |
All* | Total formula weight | 325369.3 |