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6BLF

PDE2 complexed with 2-[6-fluoro-8-methylsulfonyl-9-[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue DY1 A 1000
ChainResidue
ATYR655
ATYR827
AGLN859
APHE862
AHOH1136
AHOH1159
AHOH1160
AHOH1178
AHIS656
AASN704
ATHR768
ALEU770
ATHR805
ALEU809
AILE822
AILE826

site_idAC2
Number of Residues6
Detailsbinding site for residue ZN A 1001
ChainResidue
AHIS660
AHIS696
AASP697
AASP808
AHOH1137
AHOH1147

site_idAC3
Number of Residues6
Detailsbinding site for residue MG A 1002
ChainResidue
AASP697
AHOH1102
AHOH1125
AHOH1137
AHOH1156
AHOH1167

site_idAC4
Number of Residues14
Detailsbinding site for residue DY1 B 1000
ChainResidue
BTYR655
BASN704
BTHR768
BLEU770
BTHR805
BASP808
BLEU809
BILE826
BTYR827
BGLN859
BPHE862
BHOH1128
BHOH1158
BHOH1171

site_idAC5
Number of Residues6
Detailsbinding site for residue ZN B 1001
ChainResidue
BHIS660
BHIS696
BASP697
BASP808
BHOH1111
BHOH1176

site_idAC6
Number of Residues6
Detailsbinding site for residue MG B 1002
ChainResidue
BASP697
BHOH1103
BHOH1111
BHOH1121
BHOH1169
BHOH1183

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF
ChainResidueDetails
AHIS696-PHE707

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
ASER912
BSER912

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q922S4
ChainResidueDetails
APHE687
BGLN755
AGLY702
ASER721
AASN744
AGLN755
BPHE687
BGLY702
BSER721
BASN744

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:15938621, ECO:0000269|PubMed:19828435, ECO:0000269|PubMed:23899287, ECO:0007744|PDB:1Z1L, ECO:0007744|PDB:3IBJ, ECO:0007744|PDB:3ITM, ECO:0007744|PDB:3ITU, ECO:0007744|PDB:4HTX, ECO:0007744|PDB:4HTZ, ECO:0007744|PDB:4JIB
ChainResidueDetails
ALEU916
BLEU916

223532

PDB entries from 2024-08-07

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