6BLF

PDE2 complexed with 2-[6-fluoro-8-methylsulfonyl-9-[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	cGMP-dependent 3',5'-cyclic phosphodiesterase	polymer	373	43694.8	2	UniProt (O00408) Pfam (PF00233) In PDB	Homo sapiens (Human)	Cyclic GMP-stimulated phosphodiesterase,cGSPDE
2	A, B	[(1S)-6-fluoro-8-(methylsulfonyl)-9-{(1R)-1-[4-(trifluoromethyl)phenyl]ethyl}-2,3,4,9-tetrahydro-1H-carbazol-1-yl]acetic acid	non-polymer		497.5	2	Chemie (DY1)
3	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5		water	water		18.0	212	Chemie (HOH)

Sequence modifications

A, B: 578 - 919 (UniProt: O00408)

PDB	External Database	Details
Met 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
His 553	-	expression tag
Glu 554	-	expression tag
Asn 555	-	expression tag
Leu 556	-	expression tag
Tyr 557	-	expression tag
Phe 558	-	expression tag
Gln 559	-	expression tag
Gly 560	-	expression tag
Glu 561	-	expression tag
Leu 562	-	expression tag
Ser 563	-	expression tag
Thr 564	-	expression tag
Ser 565	-	expression tag
Leu 566	-	expression tag
Tyr 567	-	expression tag
Lys 568	-	expression tag
Lys 569	-	expression tag
Ala 570	-	expression tag
Gly 571	-	expression tag
Phe 572	-	expression tag
Asp 573	-	expression tag
Asp 574	-	expression tag
Asp 575	-	expression tag
Asp 576	-	expression tag
Lys 577	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	87389.6
Non-Polymers*	Number of molecules	6
	Total formula weight	1174.4
All*	Total formula weight	88564.0

*Water molecules are not included.