5UAN
Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0048384 | biological_process | retinoic acid receptor signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS135 |
| A | CYS138 |
| A | CYS152 |
| A | CYS155 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 502 |
| Chain | Residue |
| A | CYS177 |
| A | CYS187 |
| A | CYS190 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue 9CR A 503 |
| Chain | Residue |
| A | ALA272 |
| A | GLN275 |
| A | TRP305 |
| A | LEU309 |
| A | PHE313 |
| A | ARG316 |
| A | LEU325 |
| A | LEU326 |
| A | ALA327 |
| A | CYS432 |
| A | ILE268 |
| A | ALA271 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | CYS81 |
| B | CYS84 |
| B | CYS98 |
| B | CYS101 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 502 |
| Chain | Residue |
| B | CYS117 |
| B | CYS123 |
| B | CYS133 |
| B | CYS136 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue REA B 503 |
| Chain | Residue |
| B | ALA225 |
| B | CYS228 |
| B | LEU262 |
| B | ILE263 |
| B | ILE266 |
| B | PHE279 |
| B | SER280 |
| B | GLY294 |
Functional Information from PROSITE/UniProt
| site_id | PS00031 |
| Number of Residues | 27 |
| Details | NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Drssgk.HYgvysCegCkgFFkR |
| Chain | Residue | Details |
| A | CYS135-ARG161 | |
| B | CYS81-ARG107 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 65 |
| Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| B | CYS81-MET146 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| B | CYS81-CYS101 | |
| B | CYS117-CYS141 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4 |
| Chain | Residue | Details |
| A | CYS135 | |
| A | CYS138 | |
| A | CYS152 | |
| A | CYS155 | |
| A | CYS171 | |
| A | CYS177 | |
| A | CYS187 | |
| A | CYS190 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 |
| Chain | Residue | Details |
| A | ARG316 | |
| A | ALA327 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER129 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by EP300 => ECO:0000269|PubMed:17761950 |
| Chain | Residue | Details |
| A | LYS145 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER259 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 |
| Chain | Residue | Details |
| A | SER260 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:16912044 |
| Chain | Residue | Details |
| A | LYS108 |
