5UAN
Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 365 | 41120.4 | 1 | UniProt (P19793) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B (B) | Retinoic acid receptor beta | polymer | 397 | 44817.6 | 1 | UniProt (P10826) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (Human) | RAR-beta,HBV-activated protein,Nuclear receptor subfamily 1 group B member 2,RAR-epsilon |
| 3 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 10 | 1276.5 | 2 | UniProt (E7EWM1) UniProt (by SIFTS) (Q15596) | Homo sapiens | |
| 4 | E (E) | DNA (5'-D(*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*GP*C)-3') | polymer | 17 | 5236.4 | 1 | Homo sapiens | ||
| 5 | F (F) | DNA (5'-D(*GP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*G)-3') | polymer | 17 | 5178.4 | 1 | Homo sapiens | ||
| 6 | G, H, J, K (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | I (A) | (9cis)-retinoic acid | non-polymer | 300.4 | 1 | Chemie (9CR) | |||
| 8 | L (B) | RETINOIC ACID | non-polymer | 300.4 | 1 | Chemie (REA) |
Sequence modifications
B: 73 - 448 (UniProt: P10826)
| PDB | External Database | Details |
|---|---|---|
| Met 52 | - | initiating methionine |
| Gly 53 | - | expression tag |
| Ser 54 | - | expression tag |
| Ser 55 | - | expression tag |
| His 56 | - | expression tag |
| His 57 | - | expression tag |
| His 58 | - | expression tag |
| His 59 | - | expression tag |
| His 60 | - | expression tag |
| His 61 | - | expression tag |
| Ser 62 | - | expression tag |
| Ser 63 | - | expression tag |
| Gly 64 | - | expression tag |
| Leu 65 | - | expression tag |
| Val 66 | - | expression tag |
| Pro 67 | - | expression tag |
| Arg 68 | - | expression tag |
| Gly 69 | - | expression tag |
| Ser 70 | - | expression tag |
| His 71 | - | expression tag |
| Met 72 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 98905.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 862.5 | |
| All* | Total formula weight | 99768.3 |
