5UAN
Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 365 | 41120.4 | 1 | UniProt (P19793) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B (B) | Retinoic acid receptor beta | polymer | 397 | 44817.6 | 1 | UniProt (P10826) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (Human) | RAR-beta,HBV-activated protein,Nuclear receptor subfamily 1 group B member 2,RAR-epsilon |
| 3 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 10 | 1276.5 | 2 | UniProt (E7EWM1) UniProt (by SIFTS) (Q15596) | Homo sapiens | |
| 4 | E (E) | DNA (5'-D(*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*GP*C)-3') | polymer | 17 | 5236.4 | 1 | Homo sapiens | ||
| 5 | F (F) | DNA (5'-D(*GP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*G)-3') | polymer | 17 | 5178.4 | 1 | Homo sapiens | ||
| 6 | G, H, J, K (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | I (A) | (9cis)-retinoic acid | non-polymer | 300.4 | 1 | Chemie (9CR) | |||
| 8 | L (B) | RETINOIC ACID | non-polymer | 300.4 | 1 | Chemie (REA) PubChem (23275881) PubChem (25145416) PubChem (445925) PubChem (87179195) PubChem (87519764) PubChem (87980058) PubChem (88439848) PubChem (88525859) PubChem (88604688) PubChem (5538) PubChem (444795) PubChem (449171) PubChem (5282379) PubChem (6336207) PubChem (6336229) PubChem (6419708) PubChem (6603983) PubChem (9796370) PubChem (9861147) PubChem (10881132) PubChem (12358677) PubChem (12358678) PubChem (12358679) PubChem (12358681) PubChem (134688661) PubChem (139597075) PubChem (145826768) PubChem (166478803) |
Sequence modifications
B: 73 - 448 (UniProt: P10826)
| PDB | External Database | Details |
|---|---|---|
| Met 52 | - | initiating methionine |
| Gly 53 | - | expression tag |
| Ser 54 | - | expression tag |
| Ser 55 | - | expression tag |
| His 56 | - | expression tag |
| His 57 | - | expression tag |
| His 58 | - | expression tag |
| His 59 | - | expression tag |
| His 60 | - | expression tag |
| His 61 | - | expression tag |
| Ser 62 | - | expression tag |
| Ser 63 | - | expression tag |
| Gly 64 | - | expression tag |
| Leu 65 | - | expression tag |
| Val 66 | - | expression tag |
| Pro 67 | - | expression tag |
| Arg 68 | - | expression tag |
| Gly 69 | - | expression tag |
| Ser 70 | - | expression tag |
| His 71 | - | expression tag |
| Met 72 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 98905.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 862.5 | |
| All* | Total formula weight | 99768.3 |
