5UAN

Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Retinoic acid receptor RXR-alpha	polymer	365	41120.4	1	UniProt (P19793) Pfam (PF00105) Pfam (PF00104) In PDB	Homo sapiens (Human)	Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha
2	B	Retinoic acid receptor beta	polymer	397	44817.6	1	UniProt (P10826) Pfam (PF00105) Pfam (PF00104) In PDB	Homo sapiens (Human)	RAR-beta,HBV-activated protein,Nuclear receptor subfamily 1 group B member 2,RAR-epsilon
3	C, D	Nuclear receptor coactivator 2	polymer	10	1276.5	2	UniProt (E7EWM1) UniProt (by SIFTS) (Q15596) In PDB	Homo sapiens
4	E	DNA (5'-D(*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*GP*C)-3')	polymer	17	5236.4	1		Homo sapiens
5	F	DNA (5'-D(*GP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*G)-3')	polymer	17	5178.4	1		Homo sapiens
6	A, B	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
7	A	(9cis)-retinoic acid	non-polymer		300.4	1	Chemie (9CR)
8	B	RETINOIC ACID	non-polymer		300.4	1	Chemie (REA)

Sequence modifications

B: 73 - 448 (UniProt: P10826)

PDB	External Database	Details
Met 52	-	initiating methionine
Gly 53	-	expression tag
Ser 54	-	expression tag
Ser 55	-	expression tag
His 56	-	expression tag
His 57	-	expression tag
His 58	-	expression tag
His 59	-	expression tag
His 60	-	expression tag
His 61	-	expression tag
Ser 62	-	expression tag
Ser 63	-	expression tag
Gly 64	-	expression tag
Leu 65	-	expression tag
Val 66	-	expression tag
Pro 67	-	expression tag
Arg 68	-	expression tag
Gly 69	-	expression tag
Ser 70	-	expression tag
His 71	-	expression tag
Met 72	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	98905.8
Non-Polymers*	Number of molecules	6
	Total formula weight	862.5
All*	Total formula weight	99768.3

*Water molecules are not included.