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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5SX5

Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R.

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue SO4 K 301

Chain	Residue
K	LYS39
K	LYS45

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 K 302

Chain	Residue
K	PRO59
K	SER60

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 K 303

Chain	Residue
K	ASP1
K	GLN27
K	HIS93
M	ASN473

site_id	AC4
Number of Residues	2
Details	binding site for residue GOL K 304

Chain	Residue
K	SER9
K	PRO8

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL K 305

Chain	Residue
K	THR20
K	THR22
L	SER7
L	PRO8
L	THR20
L	THR22

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO K 306

Chain	Residue
K	GLN38
K	ALA84
K	THR85
K	GLU165
K	HOH407

site_id	AC7
Number of Residues	5
Details	binding site for residue 1PE J 301

Chain	Residue
J	ILE94
J	TYR96
J	MET114
K	GLY41
K	LYS42

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO J 302

Chain	Residue
J	ASN161
J	SER162

site_id	AC9
Number of Residues	2
Details	binding site for residue SO4 L 301

Chain	Residue
L	LEU11
L	SER12

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 L 302

Chain	Residue
L	GLN27
L	ASP28

site_id	AD2
Number of Residues	1
Details	binding site for residue SO4 L 303

Chain	Residue
L	ARG211

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 L 304

Chain	Residue
L	LYS39
L	LYS42
L	LYS45

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 L 305

Chain	Residue
L	ASP1
L	GLN27
L	HIS93
N	ASN473

site_id	AD5
Number of Residues	8
Details	binding site for residue 1PE L 306

Chain	Residue
L	SER9
L	GLN38
L	ALA84
L	THR85
L	GLY100
L	GLY101
L	LYS103
L	GLU165

site_id	AD6
Number of Residues	1
Details	binding site for residue GOL L 307

Chain	Residue
L	SER9

site_id	AD7
Number of Residues	1
Details	binding site for residue SO4 H 301

Chain	Residue
H	GLY124

site_id	AD8
Number of Residues	5
Details	binding site for residue SO4 H 302

Chain	Residue
H	ASN161
H	SER162
H	ASN203
H	HOH402
L	ASP185

site_id	AD9
Number of Residues	2
Details	binding site for residue SO4 H 303

Chain	Residue
H	SER121
H	THR122

site_id	AE1
Number of Residues	8
Details	binding site for residue 1PE H 304

Chain	Residue
H	ILE94
H	TYR96
H	GLN111
H	GLY112
H	GLU154
H	HOH415
L	GLN38
L	LYS42

site_id	AE2
Number of Residues	2
Details	binding site for residue GOL H 305

Chain	Residue
H	PRO9
H	GLY10

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO H 306

Chain	Residue
H	ASP33
N	GLN408
N	VAL417

site_id	AE4
Number of Residues	2
Details	binding site for residue SO4 N 601

Chain	Residue
M	HIS359
N	SER474

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH

Chain	Residue	Details
J	TYR200-HIS206
K	TYR192-HIS198

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1MOX, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3P0Y, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRL, ECO:0007744\|PDB:4KRM, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UIP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
M	ASP328
N	ASP328

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRL, ECO:0007744\|PDB:4KRM, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
M	ASN337
N	ASN337

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:8962717, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3P0Y, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP

Chain	Residue	Details
M	ASN389
N	ASN389

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:8962717, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3P0Y, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRL, ECO:0007744\|PDB:4KRM, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UIP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
M	ASP420
N	ASP420

218853

PDB entries from 2024-04-24

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