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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5SX5

Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R.

Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue SO4 K 301
ChainResidue
KLYS39
KLYS45
site_idAC2
Number of Residues2
Detailsbinding site for residue SO4 K 302
ChainResidue
KPRO59
KSER60
site_idAC3
Number of Residues4
Detailsbinding site for residue SO4 K 303
ChainResidue
KASP1
KGLN27
KHIS93
MASN473
site_idAC4
Number of Residues2
Detailsbinding site for residue GOL K 304
ChainResidue
KSER9
KPRO8
site_idAC5
Number of Residues6
Detailsbinding site for residue GOL K 305
ChainResidue
KTHR20
KTHR22
LSER7
LPRO8
LTHR20
LTHR22
site_idAC6
Number of Residues5
Detailsbinding site for residue EDO K 306
ChainResidue
KGLN38
KALA84
KTHR85
KGLU165
KHOH407
site_idAC7
Number of Residues5
Detailsbinding site for residue 1PE J 301
ChainResidue
JILE94
JTYR96
JMET114
KGLY41
KLYS42
site_idAC8
Number of Residues2
Detailsbinding site for residue EDO J 302
ChainResidue
JASN161
JSER162
site_idAC9
Number of Residues2
Detailsbinding site for residue SO4 L 301
ChainResidue
LLEU11
LSER12
site_idAD1
Number of Residues2
Detailsbinding site for residue SO4 L 302
ChainResidue
LGLN27
LASP28
site_idAD2
Number of Residues1
Detailsbinding site for residue SO4 L 303
ChainResidue
LARG211
site_idAD3
Number of Residues3
Detailsbinding site for residue SO4 L 304
ChainResidue
LLYS39
LLYS42
LLYS45
site_idAD4
Number of Residues4
Detailsbinding site for residue SO4 L 305
ChainResidue
LASP1
LGLN27
LHIS93
NASN473
site_idAD5
Number of Residues8
Detailsbinding site for residue 1PE L 306
ChainResidue
LSER9
LGLN38
LALA84
LTHR85
LGLY100
LGLY101
LLYS103
LGLU165
site_idAD6
Number of Residues1
Detailsbinding site for residue GOL L 307
ChainResidue
LSER9
site_idAD7
Number of Residues1
Detailsbinding site for residue SO4 H 301
ChainResidue
HGLY124
site_idAD8
Number of Residues5
Detailsbinding site for residue SO4 H 302
ChainResidue
HASN161
HSER162
HASN203
HHOH402
LASP185
site_idAD9
Number of Residues2
Detailsbinding site for residue SO4 H 303
ChainResidue
HSER121
HTHR122
site_idAE1
Number of Residues8
Detailsbinding site for residue 1PE H 304
ChainResidue
HILE94
HTYR96
HGLN111
HGLY112
HGLU154
HHOH415
LGLN38
LLYS42
site_idAE2
Number of Residues2
Detailsbinding site for residue GOL H 305
ChainResidue
HPRO9
HGLY10
site_idAE3
Number of Residues3
Detailsbinding site for residue EDO H 306
ChainResidue
HASP33
NGLN408
NVAL417
site_idAE4
Number of Residues2
Detailsbinding site for residue SO4 N 601
ChainResidue
MHIS359
NSER474
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH
ChainResidueDetails
JTYR200-HIS206
KTYR192-HIS198
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10731668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297049","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10731668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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