5SX5

Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (K, L)	Panitumumab Fab Light Chain	polymer	214	23379.9	2		Homo sapiens
2	B, D (J, H)	Panitumumab Fab Heavy Chain	polymer	221	23674.4	2		Homo sapiens
3	E, F (M, N)	Epidermal growth factor receptor	polymer	201	22350.4	2	UniProt (P00533) Pfam (PF01030)	Homo sapiens (Human)	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
4	BA, G, H, I, O... (N, K, L, H)	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)
5	J, K, U, Z (K, L, H)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	AA, L, N (H, K, J)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
7	M, T, Y (J, L, H)	PENTAETHYLENE GLYCOL	non-polymer		238.3	3	Chemie (1PE)
8	CA, DA, EA, FA, GA... (K, J, L, H, M...)	water	water		18.0	139	Chemie (HOH)

Sequence modifications

M, N: 311 - 501 (UniProt: P00533)

PDB	External Database	Details
Leu 307	-	expression tag
Glu 308	-	expression tag
Glu 309	-	expression tag
Lys 310	-	expression tag
Asp 328	Asn 352	conflict
Asp 420	Asn 444	conflict
Arg 468	Ser 492	engineered mutation
His 1502	-	expression tag
His 1503	-	expression tag
His 1504	-	expression tag
His 1505	-	expression tag
His 1506	-	expression tag
His 1507	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	138809.5
Non-Polymers*	Number of molecules	22
	Total formula weight	2422.2
All*	Total formula weight	141231.6

*Water molecules are not included.