5SX5
Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | K, L | Panitumumab Fab Light Chain | polymer | 214 | 23379.9 | 2 | Homo sapiens | ||
2 | J, H | Panitumumab Fab Heavy Chain | polymer | 221 | 23674.4 | 2 | Homo sapiens | ||
3 | M, N | Epidermal growth factor receptor | polymer | 201 | 22350.4 | 2 | UniProt (P00533) Pfam (PF01030) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
4 | N, K, L, H | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
5 | K, L, H | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
6 | H, K, J | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
7 | J, L, H | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 3 | Chemie (1PE) | |||
8 | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
M, N: 311 - 501 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Leu 307 | - | expression tag |
Glu 308 | - | expression tag |
Glu 309 | - | expression tag |
Lys 310 | - | expression tag |
Asp 328 | Asn 352 | conflict |
Asp 420 | Asn 444 | conflict |
Arg 468 | Ser 492 | engineered mutation |
His 1502 | - | expression tag |
His 1503 | - | expression tag |
His 1504 | - | expression tag |
His 1505 | - | expression tag |
His 1506 | - | expression tag |
His 1507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 138809.5 | |
Non-Polymers* | Number of molecules | 22 |
Total formula weight | 2422.2 | |
All* | Total formula weight | 141231.6 |