4WZI
Crystal structure of crosslink stabilized long-form PDE4B
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | HIS410 |
| A | HIS446 |
| A | ASP447 |
| A | ASP564 |
| A | HOH1089 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 802 |
| Chain | Residue |
| A | HIS491 |
| A | ASP605 |
| A | HIS607 |
| A | HOH906 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 803 |
| Chain | Residue |
| A | ASP397 |
| A | TYR399 |
| A | SER401 |
| A | HOH952 |
| A | HOH1052 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 804 |
| Chain | Residue |
| A | ASP447 |
| A | HOH950 |
| A | HOH956 |
| A | HOH1089 |
| A | HOH1090 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue IOD A 805 |
| Chain | Residue |
| A | ARG503 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 801 |
| Chain | Residue |
| B | HIS410 |
| B | HIS446 |
| B | ASP447 |
| B | ASP564 |
| B | HOH1039 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 802 |
| Chain | Residue |
| B | ASP397 |
| B | TYR399 |
| B | SER401 |
| B | HOH941 |
| B | HOH993 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 803 |
| Chain | Residue |
| B | ASP447 |
| B | HOH918 |
| B | HOH937 |
| B | HOH1039 |
| B | HOH1040 |
| B | HOH1041 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue IOD B 804 |
| Chain | Residue |
| B | ARG503 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS446-PHE457 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:15003452, ECO:0007744|PDB:1ROR |
| Chain | Residue | Details |
| A | HIS406 | |
| B | HIS406 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5 |
| Chain | Residue | Details |
| A | HIS406 | |
| A | GLN615 | |
| B | HIS406 | |
| B | GLN615 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P |
| Chain | Residue | Details |
| A | HIS410 | |
| B | HIS410 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P |
| Chain | Residue | Details |
| A | HIS446 | |
| B | HIS446 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15003452, ECO:0007744|PDB:1ROR |
| Chain | Residue | Details |
| A | ASP447 | |
| B | ASP447 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:3D3P |
| Chain | Residue | Details |
| A | ASP564 | |
| B | ASP564 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:15003452, ECO:0000305|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5 |
| Chain | Residue | Details |
| A | PHE618 | |
| B | PHE618 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P14646 |
| Chain | Residue | Details |
| A | SER290 | |
| A | ALA659 | |
| A | ALA661 | |
| B | SER290 | |
| B | ALA659 | |
| B | ALA661 |
