3D3P
Crystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor
Summary for 3D3P
Entry DOI | 10.2210/pdb3d3p/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | pde, phosphodiesterase, camp, alternative splicing, hydrolase, phosphoprotein, polymorphism |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41277.89 |
Authors | Somers, D.O.,Neu, M. (deposition date: 2008-05-12, release date: 2009-05-19, Last modification date: 2023-08-30) |
Primary citation | Hamblin, J.N.,Angell, T.D.,Ballantine, S.P.,Cook, C.M.,Cooper, A.W.,Dawson, J.,Delves, C.J.,Jones, P.S.,Lindvall, M.,Lucas, F.S.,Mitchell, C.J.,Neu, M.Y.,Ranshaw, L.E.,Solanke, Y.E.,Somers, D.O.,Wiseman, J.O. Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors. Bioorg.Med.Chem.Lett., 18:4237-4241, 2008 Cited by PubMed: 18539455DOI: 10.1016/j.bmcl.2008.05.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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