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3D3P

Crystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor

Summary for 3D3P
Entry DOI10.2210/pdb3d3p/pdb
DescriptorcAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordspde, phosphodiesterase, camp, alternative splicing, hydrolase, phosphoprotein, polymorphism
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight41277.89
Authors
Somers, D.O.,Neu, M. (deposition date: 2008-05-12, release date: 2009-05-19, Last modification date: 2023-08-30)
Primary citationHamblin, J.N.,Angell, T.D.,Ballantine, S.P.,Cook, C.M.,Cooper, A.W.,Dawson, J.,Delves, C.J.,Jones, P.S.,Lindvall, M.,Lucas, F.S.,Mitchell, C.J.,Neu, M.Y.,Ranshaw, L.E.,Solanke, Y.E.,Somers, D.O.,Wiseman, J.O.
Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.
Bioorg.Med.Chem.Lett., 18:4237-4241, 2008
Cited by
PubMed: 18539455
DOI: 10.1016/j.bmcl.2008.05.052
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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