3D3P
Crystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | polymer | 353 | 40583.9 | 1 | UniProt (Q07343) Pfam (PF00233) In PDB | Homo sapiens (human) | DPDE4, PDE32 |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | A | 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide | non-polymer | 379.5 | 1 | Chemie (20A) | |||
| 5 | A | ARSENIC | non-polymer | 74.9 | 3 | Chemie (ARS) | |||
| 6 | water | water | 18.0 | 303 | Chemie (HOH) |
Sequence modifications
A: 152 - 503 (UniProt: Q07343)
| PDB | External Database | Details |
|---|---|---|
| Met 151 | - | expression tag |
| Ala 482 | Ser 654 | engineered mutation |
| Ala 487 | Ser 659 | engineered mutation |
| Ala 489 | Ser 661 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40583.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 693.9 | |
| All* | Total formula weight | 41277.9 |
