4WZI

Crystal structure of crosslink stabilized long-form PDE4B

Summary for 4WZI

Entry DOI	10.2210/pdb4wzi/pdb
Related	4X0F
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, SODIUM ION, ... (6 entities in total)
Functional Keywords	phosphodiesterase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	150127.42
Authors	Cedervall, P.,Pandit, J. (deposition date: 2014-11-19, release date: 2015-03-11, Last modification date: 2023-09-27)
Primary citation	Cedervall, P.,Aulabaugh, A.,Geoghegan, K.F.,McLellan, T.J.,Pandit, J. Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4. Proc.Natl.Acad.Sci.USA, 112:E1414-E1422, 2015 Cited by PubMed: 25775568 DOI: 10.1073/pnas.1419906112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.58 Å)

Structure validation