3H7H

Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000993	molecular_function	RNA polymerase II complex binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0008270	molecular_function	zinc ion binding
A	0032044	cellular_component	DSIF complex
A	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
A	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
A	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046872	molecular_function	metal ion binding
A	0046982	molecular_function	protein heterodimerization activity
A	0140673	biological_process	transcription elongation-coupled chromatin remodeling
A	0140870	molecular_function	RNA polymerase inhibitor activity
A	0160239	biological_process	transcription pausing by RNA polymerase II
B	0006354	biological_process	DNA-templated transcription elongation
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0032784	biological_process	regulation of DNA-templated transcription elongation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME A 118

Chain	Residue
A	ASN35
A	CYS36
A	TYR39
A	VAL106
A	HOH174
A	HOH200

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 119

Chain	Residue
A	CYS36
A	CYS16
A	CYS19
A	CYS33

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	38
Details	Region: {"description":"Interaction with SUPT5H"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28892040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OIK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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