3H7H
Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000993 | molecular_function | RNA polymerase II complex binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0032044 | cellular_component | DSIF complex |
| A | 0032785 | biological_process | negative regulation of DNA-templated transcription, elongation |
| A | 0032786 | biological_process | positive regulation of DNA-templated transcription, elongation |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0140673 | biological_process | transcription elongation-coupled chromatin remodeling |
| A | 0140870 | molecular_function | RNA polymerase inhibitor activity |
| A | 0160239 | biological_process | transcription pausing by RNA polymerase II |
| B | 0006354 | biological_process | DNA-templated transcription elongation |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0032784 | biological_process | regulation of DNA-templated transcription elongation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BME A 118 |
| Chain | Residue |
| A | ASN35 |
| A | CYS36 |
| A | TYR39 |
| A | VAL106 |
| A | HOH174 |
| A | HOH200 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 119 |
| Chain | Residue |
| A | CYS36 |
| A | CYS16 |
| A | CYS19 |
| A | CYS33 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | Region: {"description":"Interaction with SUPT5H"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28892040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OIK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
