9OOI
 
 | | Crystal structure of dihydrofolate reductase (DHFR) from the filarial nematode W. bancrofti in complex with NADPH and antifolate 2-({4-[(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzoic acid (OG7 or TSD001) | | Descriptor: | 2-({4-[(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, dihydrofolate reductase | | Authors: | Frey, K.M, Goodey, N.M, Kwarteng, S. | | Deposit date: | 2025-05-15 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | A virtual screening strategy to repurpose antifolate compounds as W. Bancrofti DHFR inhibitors.
Bioorg.Med.Chem.Lett., 2025
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9OPZ
 | | Structure of the sweet receptor bound to sucralose in the compact state, extracellular domain | | Descriptor: | 4-chloro-4-deoxy-alpha-D-galactopyranose-(1-2)-1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose, Taste receptor type 1 member 2, Taste receptor type 1 member 3 | | Authors: | Wang, H, Chen, X, Dai, Y, Lee, C.H. | | Deposit date: | 2025-05-20 | | Release date: | 2025-08-27 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Structure of the sweet receptor bound to sucralose in the compact state, extracellular domain
To Be Published
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9OQ0
 | | Structure of the sweet receptor bound to sucralose in the compact state, transmembrane domain | | Descriptor: | Taste receptor type 1 member 2, Taste receptor type 1 member 3 | | Authors: | Wang, H, Chen, X, Dai, Y, Lee, C.H. | | Deposit date: | 2025-05-20 | | Release date: | 2025-08-27 | | Method: | ELECTRON MICROSCOPY (3.67 Å) | | Cite: | Structure of the sweet receptor bound to sucralose in the compact state, transmembrane domain
To Be Published
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9OVH
 | | Structure of an ancestral ethylene forming enzyme, Anc357, in complex with Mn | | Descriptor: | 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, MANGANESE (II) ION | | Authors: | Chatterjee, S, Rankin, J.A, Farrugia, M.A, Hu, J, Hausinger, R.P. | | Deposit date: | 2025-05-30 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Ancestral Sequence Reconstruction of the Ethylene-Forming Enzyme.
Biochemistry, 64, 2025
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9P0X
 | | Nanodisc-embedded human TF/FVIIa/XK1 in complex with 10H10 Fab (nanodisc-subtracted) | | Descriptor: | CALCIUM ION, Coagulation factor VII Heavy Chain, Factor VII light chain, ... | | Authors: | Photenhauer, A.L, Sedzro, J.C, Ohi, M.D, Morrissey, J.H. | | Deposit date: | 2025-06-07 | | Release date: | 2025-08-27 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism.
Blood, 2025
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9P12
 | | Lysozyme Room-Temperature In-Situ, Shipped | | Descriptor: | Lysozyme C, SODIUM ION | | Authors: | Snell, M.E, Campomizzi, C.S, Mikolajek, H, Sandy, J, Sanchez-Weatherby, J, Budziszewski, G.R, Hough, M.A, Bowman, S.E.J. | | Deposit date: | 2025-06-09 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Does crossing the pond affect crystal quality?
Biorxiv, 2025
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9P13
 | | Lysozyme Room-Temperature In-Situ, Grown On-Site | | Descriptor: | Lysozyme C, SODIUM ION | | Authors: | Snell, M.E, Campomizzi, C.S, Mikolajek, H, Sandy, J, Sanchez-Weatherby, J, Budziszewski, G.R, Hough, M.A, Bowman, S.E.J. | | Deposit date: | 2025-06-09 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Does crossing the pond affect crystal quality?
Biorxiv, 2025
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9P14
 | | Thaumatin Room-Temperature In-Situ, Grown On-Site | | Descriptor: | L(+)-TARTARIC ACID, Thaumatin I | | Authors: | Snell, M.E, Campomizzi, C.S, Mikolajek, H, Sandy, J, Sanchez-Weatherby, J, Budziszewski, G.R, Hough, M.A, Bowman, S.E.J. | | Deposit date: | 2025-06-09 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Does crossing the pond affect crystal quality?
Biorxiv, 2025
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9P15
 | | Thaumatin Room-Temperature In-Situ, Shipped | | Descriptor: | L(+)-TARTARIC ACID, Thaumatin I | | Authors: | Snell, M.E, Campomizzi, C.S, Mikolajek, H, Sandy, J, Sanchez-Weatherby, J, Budziszewski, G.R, Hough, M.A, Bowman, S.E.J. | | Deposit date: | 2025-06-09 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Does crossing the pond affect crystal quality?
Biorxiv, 2025
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9P16
 | | Thermolysin Room-Temperature In-Situ, Grown On-Site | | Descriptor: | CALCIUM ION, PHOSPHATE ION, Thermolysin, ... | | Authors: | Campomizzi, C.S, Snell, M.E, Mikolajek, H, Sandy, J, Sanchez-Weatherby, J, Budziszewski, G.R, Hough, M.A, Bowman, S.E.J. | | Deposit date: | 2025-06-09 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Does crossing the pond affect crystal quality?
Biorxiv, 2025
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9P17
 | | Thermolysin Room-Temperature In-Situ, Shipped | | Descriptor: | CALCIUM ION, PHOSPHATE ION, Thermolysin, ... | | Authors: | Campomizzi, C.S, Snell, M.E, Mikolajek, H, Sandy, J, Sanchez-Weatherby, J, Budziszewski, G.R, Hough, M.A, Bowman, S.E.J. | | Deposit date: | 2025-06-09 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Does crossing the pond affect crystal quality?
Biorxiv, 2025
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9P4V
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9P4W
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9PGO
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9PHI
 | | [18-7B AC] 18 bp tensegrity triangle that propagates via blunt-end stacking with A stacking on C at the interface | | Descriptor: | DNA (5'-D(*TP*GP*AP*TP*GP*T)-3'), DNA (5'-D(P*CP*CP*GP*TP*AP*CP*A)-3'), DNA (5'-D(P*CP*GP*AP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), ... | | Authors: | Horvath, A, Woloszyn, K, Vecchioni, S, Ohayon, Y.P, Sha, R. | | Deposit date: | 2025-07-09 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (6.02 Å) | | Cite: | Shifted tensegrity triangles
To Be Published
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9PHK
 | | [19-7B TG] 19 bp tensegrity triangle that propagates via blunt-end stacking with T stacking on G at the interface | | Descriptor: | DNA (5'-D(*AP*GP*AP*TP*GP*T)-3'), DNA (5'-D(*GP*GP*AP*GP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*T)-3'), DNA (5'-D(P*CP*CP*GP*TP*AP*CP*A)-3'), ... | | Authors: | Horvath, A, Woloszyn, K, Vecchioni, S, Ohayon, Y.P, Sha, R. | | Deposit date: | 2025-07-09 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (6.01 Å) | | Cite: | Shifted tensegrity triangles
To Be Published
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9PHM
 | | [A4J-R] Asymmetric tensegrity triangle formed via toehold mediated displacement of the center strand | | Descriptor: | DNA (5'-D(*AP*AP*CP*CP*TP*AP*CP*CP*TP*GP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*T)-3'), DNA (5'-D(*CP*AP*GP*AP*TP*AP*CP*CP*TP*GP*AP*TP*CP*GP*GP*AP*CP*TP*AP*CP*G)-3'), DNA (5'-D(*GP*AP*GP*CP*GP*AP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), ... | | Authors: | Horvath, A, Wang, M, Woloszyn, K, Vecchioni, S, Ohayon, Y.P, Sha, R. | | Deposit date: | 2025-07-09 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (6.55 Å) | | Cite: | Single stranded regions in Tensegrity Triangle
To Be Published
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9PHP
 | | [19-7B AG] 19 bp tensegrity triangle that propagates via blunt-end stacking with A stacking on G at the interface | | Descriptor: | DNA (5'-D(*GP*CP*AP*GP*CP*CP*TP*GP*TP*A)-3'), DNA (5'-D(*TP*GP*AP*TP*GP*TP*GP*GP*CP*TP*GP*C)-3'), DNA (5'-D(P*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), ... | | Authors: | Horvath, A, Vecchioni, S, Woloszyn, K, Ohayon, Y.P, Sha, R. | | Deposit date: | 2025-07-09 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (4.33 Å) | | Cite: | Shifted tensegrity triangles
To Be Published
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9PLU
 | | [20-7B TG] 20 bp tensegrity triangle that propagates via blunt-end stacking with T stacking on G at the interface | | Descriptor: | DNA (5'-D(*AP*GP*AP*CP*TP*GP*TP*GP*GP*CP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*GP*CP*CP*TP*GP*TP*A)-3'), DNA (5'-D(P*CP*GP*GP*AP*CP*AP*GP*TP*CP*T)-3'), ... | | Authors: | Horvath, A, Woloszyn, K, Vecchioni, S, Ohayon, Y.P, Sha, R. | | Deposit date: | 2025-07-16 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (5.67 Å) | | Cite: | Blunt-end Tensegrity Triangles
To Be Published
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9PYF
 | | uPA Inhibitory Fab AB2 Complex | | Descriptor: | AB2 Fab Heavy Chain, AB2 Fab Light Chain, Urokinase-type plasminogen activator | | Authors: | Anderson, K.J, Bohn, M.F. | | Deposit date: | 2025-08-07 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity.
Biochim Biophys Acta Proteins Proteom, 1869, 2021
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9Q1B
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9Q1D
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9QCL
 | | S.aureus ClpC tetradecameric resting state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC | | Authors: | Engelhardt, L, Carroni, M. | | Deposit date: | 2025-03-04 | | Release date: | 2025-08-27 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides
To Be Published
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9QEU
 | | Structure of CHIP E3 ubiquitin ligase TPR domain in complex with compound 1 | | Descriptor: | E3 ubiquitin-protein ligase CHIP, SULFATE ION, ~{N}-[(1~{R},2~{R})-2-[[(1~{S})-1-(2-methoxyphenyl)-3-(methylamino)-3-oxidanylidene-propyl]carbamoyl]cyclopentyl]-4,5,6,7-tetrahydro-1~{H}-indazole-3-carboxamide | | Authors: | Breed, J. | | Deposit date: | 2025-03-11 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.353 Å) | | Cite: | Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen.
Acs Med.Chem.Lett., 16, 2025
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9QF1
 | | Structure of CHIP E3 ubiquitin ligase TPR domain in complex with compound 2 | | Descriptor: | E3 ubiquitin-protein ligase CHIP, SULFATE ION, ~{N}-methyl-~{N}-[(1~{R})-1-pyridin-2-yl-3-pyrrolidin-1-yl-propyl]-5-[4,5,6,7-tetrakis(fluoranyl)-1~{H}-indol-3-yl]-1,3,4-oxadiazol-2-amine | | Authors: | Breed, J. | | Deposit date: | 2025-03-11 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.511 Å) | | Cite: | Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen.
Acs Med.Chem.Lett., 16, 2025
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