9VLF

Structural studies on the conformation changes induced by ligand binding in an Adenine phosphoribosyltransferase (FnAPRT) from Fusobacterium nucleatum

Summary for 9VLF

• Entry DOI: 10.2210/pdb9vlf/pdb
• Descriptor: Adenine phosphoribosyltransferase, PHOSPHATE ION, ADENOSINE MONOPHOSPHATE, ... (4 entities in total)
• Functional Keywords: fusobacterium nucleatum, adenine phosphoribosyltransferase, ligand binding, transferase
• Biological source: Fusobacterium nucleatum
• Total number of polymer chains: 1
• Total formula weight: 19375.19

Authors

Kim, B.,Hwang, J.,Do, H.,Lee, J.H. (deposition date: 2025-06-25, release date: 2026-02-11)

Primary citation

Kim, B.,Hwang, J.,Do, H.,Shim, Y.S.,Lee, J.H.
Structural Insights into Ligand-Induced Conformational Changes in Adenine Phosphoribosyl Transferase from Fusobacterium nucleatum.
Protein Pept.Lett., 2026

PubMed Abstract: Adenine phosphoribosyltransferase (APRT) is an enzyme that facilitates adenosine monophosphate (AMP) biosynthesis by transferring a phosphoribosyl group to adenine using phosphoribosyl pyrophosphate as a donor. While the human enzyme is well characterized, structural insights into bacterial APRTs remain limited. is associated with periodontal disease, yet its APRT enzyme (FnAPRT) has not been structurally investigated.

PubMed: 41588988
DOI: 10.2174/0109298665403166251021110505

Experimental method

X-RAY DIFFRACTION (1.61 Å)