9VA3
Solution NMR structures of hTERT DNA G-quadruplexes (G4s) in complex with small molecule ZBH-01
This is a non-PDB format compatible entry.
Summary for 9VA3
| Entry DOI | 10.2210/pdb9va3/pdb |
| Descriptor | DNA (5'-D(*AP*AP*TP*GP*GP*GP*AP*GP*GP*GP*TP*CP*TP*GP*GP*GP*AP*GP*GP*GP*CP*C)-3'), POTASSIUM ION, (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl (2-(4-methylpiperazin-1-yl)-2-oxoethyl)carbamate (3 entities in total) |
| Functional Keywords | g-quadruplexes, topoisomerase i, zbh-01, dna |
| Biological source | Homo sapiens |
| Total number of polymer chains | 1 |
| Total formula weight | 7592.27 |
| Authors | |
| Primary citation | Li, Y.,Ji, D.,Jia, Y.,Liang, Y.,Wei, E.,Gao, C.,Li, Y.,Zeng, C.,Wang, L.,Wang, C.,Guo, Z.,Zhang, Y.,Zhou, M.-M.,Wu, D.,Zeng, L. Dual Targeting of Topoisomerase I and DNA G-quadruplexes Enhances Senescence Response and Chemosensitivity in Colorectal Cancer Cells To Be Published, |
| Experimental method | SOLUTION NMR |
Structure validation
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