8G0D
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![BU of 8g0d by Molmil](/molmil-images/mine/8g0d) | Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 2 (backbone model) | Descriptor: | (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | Authors: | Courbon, G.M, Rubinstein, J.L. | Deposit date: | 2023-01-31 | Release date: | 2023-02-15 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
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8G0E
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![BU of 8g0e by Molmil](/molmil-images/mine/8g0e) | Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 3 | Descriptor: | (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | Authors: | Courbon, G.M, Rubinstein, J.L. | Deposit date: | 2023-01-31 | Release date: | 2023-02-15 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
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8G29
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![BU of 8g29 by Molmil](/molmil-images/mine/8g29) | Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | Deposit date: | 2023-02-03 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G2A
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![BU of 8g2a by Molmil](/molmil-images/mine/8g2a) | Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | Deposit date: | 2023-02-03 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G2B
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![BU of 8g2b by Molmil](/molmil-images/mine/8g2b) | Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | Deposit date: | 2023-02-03 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G2C
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![BU of 8g2c by Molmil](/molmil-images/mine/8g2c) | Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | Deposit date: | 2023-02-03 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G2D
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![BU of 8g2d by Molmil](/molmil-images/mine/8g2d) | Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | Deposit date: | 2023-02-03 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G2U
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![BU of 8g2u by Molmil](/molmil-images/mine/8g2u) | Time-resolved cryo-EM study of the 70S recycling by the HflX:control-apo-70S at 900ms | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Bhattacharjee, S, Brown, P.Z, Frank, J. | Deposit date: | 2023-02-06 | Release date: | 2023-12-06 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Time resolution in cryo-EM using a PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling. Cell, 187, 2024
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8G2Z
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![BU of 8g2z by Molmil](/molmil-images/mine/8g2z) | 48-nm doublet microtubule from Tetrahymena thermophila strain CU428 | Descriptor: | B2B3_fMIP, B5B6_fMIP, CFAM166A, ... | Authors: | Black, C.S, Kubo, S, Yang, S.K, Bui, K.H. | Deposit date: | 2023-02-06 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins. Nat Commun, 14, 2023
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8G31
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![BU of 8g31 by Molmil](/molmil-images/mine/8g31) | Time-resolved cryo-EM study of the 70S recycling by the HflX:2nd Intermediate | Descriptor: | 16S, 23S, 30S ribosomal protein S10, ... | Authors: | Bhattacharjee, S, Brown, P.Z, Frank, J. | Deposit date: | 2023-02-06 | Release date: | 2023-12-06 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Time resolution in cryo-EM using a PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling. Cell, 187, 2024
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8G32
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![BU of 8g32 by Molmil](/molmil-images/mine/8g32) | Pro-form of a CDCL short from E. anophelis | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | Authors: | Johnstone, B.A, Christie, M.P, Morton, C.J, Parker, M.W. | Deposit date: | 2023-02-06 | Release date: | 2024-02-07 | Last modified: | 2024-06-26 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria. Nat Commun, 15, 2024
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8G33
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![BU of 8g33 by Molmil](/molmil-images/mine/8g33) | |
8G34
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![BU of 8g34 by Molmil](/molmil-images/mine/8g34) | Time-resolved cryo-EM study of the 70S recycling by the HflX:1st intermediate | Descriptor: | 16S, 23S, 30S ribosomal protein S10, ... | Authors: | Bhattacharjee, S, Brown, P.Z, Frank, J. | Deposit date: | 2023-02-06 | Release date: | 2023-12-06 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Time resolution in cryo-EM using a PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling. Cell, 187, 2024
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8G38
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![BU of 8g38 by Molmil](/molmil-images/mine/8g38) | Time-resolved cryo-EM study of the 70S recycling by the HflX:3rd Intermediate | Descriptor: | 16S, 23S, 30S ribosomal protein S10, ... | Authors: | Bhattacharjee, S, Brown, P.Z, Frank, J. | Deposit date: | 2023-02-07 | Release date: | 2023-12-06 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Time resolution in cryo-EM using a PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling. Cell, 187, 2024
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8G3D
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![BU of 8g3d by Molmil](/molmil-images/mine/8g3d) | 48-nm doublet microtubule from Tetrahymena thermophila strain K40R | Descriptor: | B2B3_fMIP, B5B6_fMIP, CFAM166A, ... | Authors: | Black, C.S, Kubo, S, Yang, S.K, Bui, K.H. | Deposit date: | 2023-02-07 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins. Nat Commun, 14, 2023
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8G4L
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![BU of 8g4l by Molmil](/molmil-images/mine/8g4l) | Cryo-EM structure of the human cardiac myosin filament | Descriptor: | Myosin light chain 3, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, ... | Authors: | Dutta, D, Nguyen, V, Padron, R, Craig, R. | Deposit date: | 2023-02-10 | Release date: | 2023-11-01 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Cryo-EM structure of the human cardiac myosin filament. Nature, 623, 2023
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8G4N
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![BU of 8g4n by Molmil](/molmil-images/mine/8g4n) | Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroids | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, DODECANE, ... | Authors: | Sun, C, Gouaux, E. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622, 2023
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8G4S
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![BU of 8g4s by Molmil](/molmil-images/mine/8g4s) | 40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V2 conformation with mRNA and three tRNAs. | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S25, ... | Authors: | Eiler, D.R, Wimberly, B.T, Bilodeau, D.Y, Rissland, O.S, Kieft, J.S. | Deposit date: | 2023-02-10 | Release date: | 2024-01-31 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function. Structure, 32, 2024
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8G4X
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![BU of 8g4x by Molmil](/molmil-images/mine/8g4x) | Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA and allopregnanolone | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sun, C, Gouaux, E. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.56 Å) | Cite: | Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622, 2023
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8G5E
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![BU of 8g5e by Molmil](/molmil-images/mine/8g5e) | Crystal Structure of SETDB1 Tudor domain in complex with UNC6535 | Descriptor: | Histone-lysine N-methyltransferase SETDB1, N~4~-[6-(dimethylamino)hexyl]-N~2~-[5-(dimethylamino)pentyl]-6,7-dimethoxyquinazoline-2,4-diamine, UNKNOWN ATOM OR ION | Authors: | Beldar, S, Dong, A, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | Deposit date: | 2023-02-13 | Release date: | 2023-02-22 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Crystal Structure of SETDB1 Tudor domain in complex with UNC6535 To be published
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8G5F
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![BU of 8g5f by Molmil](/molmil-images/mine/8g5f) | Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA and allopregnanolone | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1, ... | Authors: | Sun, C, Gouaux, E. | Deposit date: | 2023-02-13 | Release date: | 2023-09-20 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622, 2023
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8G5G
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![BU of 8g5g by Molmil](/molmil-images/mine/8g5g) | Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroid | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1, ... | Authors: | Sun, C, Gouaux, E. | Deposit date: | 2023-02-13 | Release date: | 2023-09-20 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622, 2023
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8G5H
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![BU of 8g5h by Molmil](/molmil-images/mine/8g5h) | Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroid | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1, ... | Authors: | Sun, C, Gouaux, E. | Deposit date: | 2023-02-13 | Release date: | 2023-09-20 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622, 2023
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8G5Y
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![BU of 8g5y by Molmil](/molmil-images/mine/8g5y) | mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-02-14 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.29 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
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8G5Z
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![BU of 8g5z by Molmil](/molmil-images/mine/8g5z) | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-02-14 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
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