신종 코로나바이러스 특집 콘텐츠

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코로나 바이러스, 2020. David S. Goodsell @ RCSB PDB에 의한 오리지널 일러스트를 수정

신종 코로나바이러스 감염증 (Novel Coronavirus disease 2019:COVID-19)의 확산이 세계적으로 매우 큰 문제가 되고 있습니다. 시급히 새로운 바이러스（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）를 이해하고 효과적인 약을 개발하기 위해, 신속하게 구조 생물학 연구가 시작되고 있습니다. PDBj는 사용자의 편의를 도모하기 위해 신종 코로나바이러스의 특집 페이지를 제공하고 있습니다. 매주 수요일에 최신 항목이 추가됩니다.

바이러스 단백질에 관한 해설기사는 아래의 「이달의 분자」 페이지를 참조하십시오.

「전체 엔트리」 탭에는, 모든 PDB ID가 포함되어 있습니다. 이용자가 전체의 독립된 엔트리를 검색하고 싶을 때 사용하실 수 있으며, 동일 저자에 의한 그룹등록의 엔트리도 전부 구별되어 있습니다. 「대표구조」 탭에는, 분해능이 가장 높은 대표구조만을 표지하고 있습니다. 아미노산 서열이 100 % 일치하는 PDB 엔트리의 경우, 다른 리간드를 포함하여도 대표구조에는 제외됩니다. 「최신 엔트리」 탭은, 이번주 공개된 가장 최근의 엔트리 입니다.

Created: 2020-09-03 (last edited: more than 1 year ago)

전체 엔트리 (5197)대표구조 (2266)최신 엔트리 (44)

9ML8

Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-B1 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-B1 heavy chain, M8b-B1 light chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML9

Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-C9 Fab
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-C9 heavy chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	X-RAY DIFFRACTION (2.59 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9MRW

Functional Implications of Hexameric Dynamics in SARS-CoV-2 Nsp15
Descriptor:	Uridylate-specific endoribonuclease nsp15
Authors:	Ketawala, G.K, Sonowal, M, Schrag, L, Fromme, R, Botha, S, Fromme, P.
Deposit date:	2025-01-08
Release date:	2025-06-04
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Functional implications of hexameric dynamics in SARS-CoV-2 Nsp15. Protein Sci., 34, 2025

9MRY

Functional Implications of HexamericDynamics in SARS-CoV-2 Nsp15
Descriptor:	Uridylate-specific endoribonuclease nsp15
Authors:	Ketawala, G.K, Sonowal, M, Schrag, L, Fromme, R, Botha, S, Fromme, P.
Deposit date:	2025-01-09
Release date:	2025-06-04
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Functional implications of hexameric dynamics in SARS-CoV-2 Nsp15. Protein Sci., 34, 2025

8XCH

SARS-CoV-2 Replication-Transcription Complex has a dimer-of-dimeric architecture (ddRTC) in pre-capping initiation.
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ...
Authors:	Yan, L, Lou, Z.
Deposit date:	2023-12-09
Release date:	2025-06-11
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Structural basis for template-product RNA duplex unwinding by SARS-CoV-2 helicase To Be Published

8ZPQ

Crystal structure of SARS-Cov-2-BQ1.1-RBD and 70fab
Descriptor:	70fab-H, 70fab-L, Spike protein S1
Authors:	Wu, Y, Gao, F.
Deposit date:	2024-05-31
Release date:	2025-06-11
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Crystal structure of SARS-Cov-2-BQ1.1-RBD and 70fab To Be Published

8ZQ8

SARS-Cov-2 3CL protease in complex with macrocyclic inhibitor CG-1039
Descriptor:	3C-like proteinase nsp5, CG-1039
Authors:	Chen, X, Hou, K, Tang, X.
Deposit date:	2024-06-01
Release date:	2025-06-11
Method:	X-RAY DIFFRACTION (1.77 Å)
Cite:	SARS-Cov-2 3CL protease in complex with macrocyclic inhibitor CG-1039 To Be Published

8ZT9

The Crystal structure of mol066 bound to the main protease (3CLpro/Mpro) of SARS-CoV-2
Descriptor:	3C-like proteinase, 6-[(6-chloranyl-2-propan-2-yl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]pyrimidine-2,4-dione, GLYCEROL
Authors:	Yan, M, Zhang, H.
Deposit date:	2024-06-06
Release date:	2025-06-11
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Development of pyrimidone derivatives as nonpeptidic and noncovalent 3-chymotrypsin-like protease (3CL pro ) inhibitors with anti-coronavirus activities. Bioorg.Chem., 154, 2025

8ZUC

The Crystal structure of mol080 bound to the main protease (3CLpro/Mpro) of SARS-CoV-2
Descriptor:	3C-like proteinase, 6-[[6-chloranyl-2-(3-methylbutyl)indazol-5-yl]amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]pyrimidine-2,4-dione
Authors:	Yan, M, Zhang, H.
Deposit date:	2024-06-08
Release date:	2025-06-11
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Development of pyrimidone derivatives as nonpeptidic and noncovalent 3-chymotrypsin-like protease (3CL pro ) inhibitors with anti-coronavirus activities. Bioorg.Chem., 154, 2025

9FC2

The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 4.
Descriptor:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
Authors:	Casasnovas, J.M, Fernandez, L.A, Silva, K.
Deposit date:	2024-05-15
Release date:	2025-06-11
Method:	X-RAY DIFFRACTION (1.21 Å)
Cite:	Integrating immune library probing with structure-based computational design to develop potent neutralizing nanobodies against emerging SARS-CoV-2 variants. Mabs, 17, 2025

9GUB

SARS-CoV-2 Mac1 in complex with MCD-628
Descriptor:	(2~{S})-3-(1~{H}-indol-3-yl)-2-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-ylamino)propanoic acid, Papain-like protease nsp3
Authors:	Duong, M, Paakkonen, J, Lehtio, L.
Deposit date:	2024-09-19
Release date:	2025-06-11
Last modified:	2025-06-25
Method:	X-RAY DIFFRACTION (1.1 Å)
Cite:	Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication. Mbio, 16, 2025

9NPX

SARS-CoV-2 nsp1 bound to the Rhinolophus lepidus 40S ribosomal subunit (local refinement of the 40S body)
Descriptor:	18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S13, ...
Authors:	Gen, R, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:	2025-03-11
Release date:	2025-06-11
Method:	ELECTRON MICROSCOPY (2.1 Å)
Cite:	SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals. Cell Rep, 44, 2025

9C7X

Crystal structure of SARS-CoV-2 antibody 1H06 in complex with a HR2 peptide
Descriptor:	Heavy Chain of SARS-CoV-2 antibody 1H06, Light Chain of SARS-CoV-2 antibody 1H06, Spike protein S2'
Authors:	Van Wazer, D.J, Zhou, T, Kwong, P.D.
Deposit date:	2024-06-11
Release date:	2025-06-18
Method:	X-RAY DIFFRACTION (1.96 Å)
Cite:	SARS-CoV-2 Peptide Immunization in Mice Elicits Broadly Neutralizing Antibodies Targeting Cryptic S2 Helical-Stem Epitope To Be Published

9EEI

Crystal structure of the SARS-CoV-2 Omicron nsp5 main protease (Mpro) E166V mutant in complex with inhibitor GC376
Descriptor:	3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide
Authors:	Neilsen, G, Kirby, K.A, Sarafianos, S.G.
Deposit date:	2024-11-19
Release date:	2025-06-18
Method:	X-RAY DIFFRACTION (2.76 Å)
Cite:	Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease. Sci Adv, 11, 2025

9IKZ

SARS-CoV-2 E-RTC bound to pRNA-nsp9 and GDP-BeF3-
Descriptor:	BERYLLIUM TRIFLUORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Helicase nsp13, ...
Authors:	Yan, L.M, Huang, Y.C, Liu, Y.X, Rao, Z.H, Lou, Z.Y.
Deposit date:	2024-06-29
Release date:	2025-06-18
Method:	ELECTRON MICROSCOPY (3.14 Å)
Cite:	Substrate selection and transition reveal the mechanism for RNA capping catalyzed by SARS-CoV-2 NiRAN To Be Published

9VAO

Crystal structure of Papain-like protease (PLpro) from SARS-CoV-2
Descriptor:	GLYCEROL, PHOSPHATE ION, Papain-like protease nsp3, ...
Authors:	Arya, R, Ganesh, J, Prashar, V, Kumar, M.
Deposit date:	2025-06-03
Release date:	2025-06-18
Method:	X-RAY DIFFRACTION (1.82 Å)
Cite:	Crystal structure of Papain-like protease (PLpro) from SARS-CoV-2 To Be Published

9CPP

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-17 and CC12.3
Descriptor:	CC12.3 Fab heavy chain, CC12.3 Fab light chain, CITRIC ACID, ...
Authors:	Feng, Z, Wilson, I.A.
Deposit date:	2024-07-18
Release date:	2025-06-25
Method:	X-RAY DIFFRACTION (3.19 Å)
Cite:	Structures of CR3022-like antibodies To Be Published

9CPQ

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-44 and CC12.3
Descriptor:	CC12.3 Fab heavy chain, CC12.3 Fab light chain, CITRIC ACID, ...
Authors:	Feng, Z, Wilson, I.A.
Deposit date:	2024-07-18
Release date:	2025-06-25
Method:	X-RAY DIFFRACTION (2.88 Å)
Cite:	Structures of CR3022-like antibodies To Be Published

9CPR

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-90 and CC12.3
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 Fab heavy chain, CC12.3 Fab light chain, ...
Authors:	Feng, Z, Wilson, I.A.
Deposit date:	2024-07-18
Release date:	2025-06-25
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Structures of CR3022-like antibodies To Be Published

9CPS

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-91 and CC12.3
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 Fab heavy chain, CC12.3 Fab light chain, ...
Authors:	Feng, Z, Wilson, I.A.
Deposit date:	2024-07-18
Release date:	2025-06-25
Method:	X-RAY DIFFRACTION (3.03 Å)
Cite:	Structures of CR3022-like antibodies To Be Published

9CPT

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-92 and CC12.3
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 Fab heavy chain, CC12.3 Fab light chain, ...
Authors:	Feng, Z, Wilson, I.A.
Deposit date:	2024-07-18
Release date:	2025-06-25
Method:	X-RAY DIFFRACTION (3.51 Å)
Cite:	Structures of CR3022-like antibodies To Be Published

9CPU

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C03-0304 and CC12.3
Descriptor:	C03-0304 Fab heavy chain, C03-0304 Fab light chain, CC12.3 Fab heavy chain, ...
Authors:	Feng, Z, Wilson, I.A.
Deposit date:	2024-07-18
Release date:	2025-06-25
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structures of CR3022-like antibodies To Be Published

9CPV

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C03-0614 and CC12.3
Descriptor:	C03-0614 Fab heavy chain, C03-0614 Fab light chain, CC12.3 Fab heavy chain, ...
Authors:	Feng, Z, Wilson, I.A.
Deposit date:	2024-07-18
Release date:	2025-06-25
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Structures of CR3022-like antibodies To Be Published

9CPW

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C11-1036 and CC12.3
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C11-1036 Fab heavy chain, C11-1036 Fab light chain, ...
Authors:	Feng, Z, Wilson, I.A.
Deposit date:	2024-07-18
Release date:	2025-06-25
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Structures of CR3022-like antibodies To Be Published

9CPX

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C03-0138 and CC12.3
Descriptor:	C03-0138 Fab heavy chain, C03-0138 Fab light chain, CC12.3 Fab heavy chain, ...
Authors:	Feng, Z, Wilson, I.A.
Deposit date:	2024-07-18
Release date:	2025-06-25
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structures of CR3022-like antibodies To Be Published

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