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新型コロナウイルスの構造情報

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コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症(Novel Coronavirus disease 2019: COVID-19)の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)を理解し有効な薬を開発するため,関連するタンパク質の構造研究は既に始まっています。そして,解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため,新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは,同じ著者によるグループ登録のエントリーも全て区別し,すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており,アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは,今週公開された最も新しいエントリーです。


作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
8I4F
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Omicron spike variant XBB with n3130v-Fc
分子名称: Spike glycoprotein, n3130v-Fc
著者Hao, A.H, Zhang, X, Chen, Z.G, Sun, L.
登録日2023-01-19
公開日2023-12-27
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants.
Signal Transduct Target Ther, 8, 2023
8I4G
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Omicron spike variant BQ.1.1 with n3130v-Fc
分子名称: Spike glycoprotein, n3130v-Fc
著者Hao, A.H, Zhang, X, Chen, Z.G, Sun, L.
登録日2023-01-19
公開日2023-12-27
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants.
Signal Transduct Target Ther, 8, 2023
8JJE
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RBD of SARS-CoV2 spike protein with ACE2 decoy
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
著者Kishikawa, J, Hirose, M, Kato, T, Okamoto, T.
登録日2023-05-30
公開日2023-12-27
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.
Sci Transl Med, 15, 2023
8K5G
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Structure of the SARS-CoV-2 BA.1 RBD with UT28-RD
分子名称: Spike protein S1, UT28K-RD Fab Heavy chain, UT28K-RD Fab Light chain
著者Chen, L, Kita, S, Anraku, Y, Maenaka, K.
登録日2023-07-21
公開日2023-12-27
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1.
Structure, 32, 2024
8K5H
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Structure of the SARS-CoV-2 BA.1 spike with UT28-RD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Chen, L, Kita, S, Anraku, Y, Maenaka, K.
登録日2023-07-21
公開日2023-12-27
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1.
Structure, 32, 2024
8TH1
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Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein D3L mutant
分子名称: Nucleoprotein, Ras GTPase-activating protein-binding protein 1
著者Hughes, M.P, Taylor, J.P, Yang, Z.
登録日2023-07-13
公開日2023-12-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Cell Rep, 43, 2024
8IHO
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Crystal structures of SARS-CoV-2 papain-like protease in complex with covalent inhibitors
分子名称: Papain-like protease nsp3, ZINC ION, covalent inhibitor
著者Wang, Q, Hu, H, Li, M, Xu, Y.
登録日2023-02-23
公開日2024-01-03
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease.
Int J Mol Sci, 24, 2023
8JYK
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Structure of the SARS-CoV-2 XBB.1.5 spike glycoprotein (closed state 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Yajima, H, Anraku, Y, Kita, S, Kimura, K, Sasaki, J, Sasaki-Tabata, K, Maenaka, K, Hashiguchi, T.
登録日2023-07-03
公開日2024-01-03
実験手法ELECTRON MICROSCOPY (2.59 Å)
主引用文献Virological characteristics of the SARS-CoV-2 XBB.1.5 variant
To Be Published
8JYN
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Structure of SARS-CoV-2 XBB.1.5 spike glycoprotein in complex with ACE2 (1-up state)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
著者Yajima, H, Anraku, Y, Kita, S, Kimura, K, Sasaki, J, Sasaki-Tabata, K, Maenaka, K, Hashiguchi, T.
登録日2023-07-03
公開日2024-01-03
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Virological characteristics of the SARS-CoV-2 XBB.1.5 variant
To Be Published
8FHY
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Crystal structure of the SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5021
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, MALONATE ION, ...
著者Sankhala, R.S, Jensen, J.L, Joyce, M.G.
登録日2022-12-15
公開日2024-01-17
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques.
Nat Commun, 15, 2024
8FI9
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Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5001
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Spike protein S1, ...
著者Sankhala, R.S, Jensen, J.L, Joyce, M.G.
登録日2022-12-15
公開日2024-01-17
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques.
Nat Commun, 15, 2024
8HZR
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Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with PF07321332
分子名称: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
著者Zeng, X.Y, Zhang, J, Li, J.
登録日2023-01-09
公開日2024-01-17
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with PF07321332
To Be Published
8TM1
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BU of 8tm1 by Molmil
Antibody N3-1 bound to RBDs in the up and down conformations
分子名称: N3-1 Fab heavy chain, N3-1 Fab light chain, Spike glycoprotein
著者Hsieh, C.-L, McLellan, J.S.
登録日2023-07-27
公開日2024-01-17
実験手法ELECTRON MICROSCOPY (2.79 Å)
主引用文献SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode.
Commun Biol, 6, 2023
8VCI
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BU of 8vci by Molmil
SARS-CoV-2 Frameshift Stimulatory Element with Upstream Multibranch Loop
分子名称: Frameshift Stimulatory Element with Upstream Multi-branch Loop
著者Peterson, J.M, Becker, S.T, O'Leary, C.A, Juneja, P, Yang, Y, Moss, W.N.
登録日2023-12-14
公開日2024-01-17
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (6.1 Å)
主引用文献Structure of the SARS-CoV-2 Frameshift Stimulatory Element with an Upstream Multibranch Loop.
Biochemistry, 63, 2024
8G72
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SARS-CoV-2 spike/Nb2 complex with 1 RBD up (local refinement at 5.6 A)
分子名称: Nanosota-2, Spike glycoprotein
著者Ye, G, Bu, F, Liu, B, Li, F.
登録日2023-02-16
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (5.6 Å)
主引用文献Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19.
J.Virol., 97, 2023
8G73
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SARS-CoV-2 spike/Nb3 complex with 2 RBDs up and 3 Nb3 bound at 2.5 A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-3, ...
著者Ye, G, Bu, F, Liu, B, Li, F.
登録日2023-02-16
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19.
J.Virol., 97, 2023
8G74
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SARS-CoV-2 spike/Nb3 complex with 1 RBD up and 2 Nb3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-3, ...
著者Ye, G, Bu, F, Liu, B, Li, F.
登録日2023-02-16
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19.
J.Virol., 97, 2023
8G75
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SARS-CoV-2 spike/Nb4 complex with 2 RBDs up and 3 Nb4 bound
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-4, ...
著者Ye, G, Bu, F, Liu, B, Li, F.
登録日2023-02-16
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19.
J.Virol., 97, 2023
8K3K
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BU of 8k3k by Molmil
The crystal structure of nanobody Nb4 in complex with receptor binding domain (RBD) of BA.1 Spike protein
分子名称: Nanobody Nb4, Spike protein S1
著者Wang, H.Y, Xu, W.Q.
登録日2023-07-16
公開日2024-01-24
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses, including all major Omicron strains.
MedComm (2020), 4, 2023
8U1G
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Prefusion-stabilized SARS-CoV-2 S2 subunit
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2
著者Hsieh, C.-L, McLellan, J.S.
登録日2023-08-31
公開日2024-01-24
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of prefusion-stabilized SARS-CoV-2 S2-only antigen
To Be Published
8UH8
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BU of 8uh8 by Molmil
Crystal structure of SARS-CoV-2 main protease E166V (Apo structure)
分子名称: ORF1a polyprotein
著者Bulut, H, Hayashi, H, Kuwata, N, Tsuji, K, Das, D, Tamamura, H, Mitsuya, H.
登録日2023-10-07
公開日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献TKB272, an Orally Available SARS-CoV-2-Mpro Inhibitor Containing 5-Fluorobenzothiazole, Potently Blocks SARS-CoV-2 Replication without Ritonavir
To Be Published
8ENS
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Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 spike tail hepta-peptide
分子名称: Coatomer subunit beta', spike tail hepta-peptide
著者Dey, D, Hasan, S.S.
登録日2022-09-30
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.
Nat Commun, 14, 2023
8ENW
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Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 clientized spike tail heptapeptide.
分子名称: 1,2-ETHANEDIOL, Clientized spike tail peptide, Coatomer subunit beta'
著者Dey, D, Hasan, S.S.
登録日2022-09-30
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.
Nat Commun, 14, 2023
8ENX
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Crystal structure of beta'-COPI-WD40 domain Y33A mutant in complex with SARS-CoV-2 clientized spike tail heptapeptide.
分子名称: Clientized spike tail heptapeptide, Coatomer subunit beta'
著者Dey, D, Hasan, S.S.
登録日2022-09-30
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.
Nat Commun, 14, 2023
8FWO
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Crystal structure of SARS-CoV-2 papain-like protease
分子名称: CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ...
著者Bezerra, E.H.S, Soprano, A.S, Tonoli, C.C.C, Prado, P.F.V, da Silva, J.C, Franchini, K.G, Trivella, D.B.B, Benedetti, C.E.
登録日2023-01-23
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of SARS-CoV-2 papain-like protease
To Be Published

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件を2024-07-17に公開中

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