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-基本情報
登録情報 | データベース: PDB / ID: 2vz6 | ||||||
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タイトル | Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804 | ||||||
要素 | CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN | ||||||
キーワード | TRANSFERASE (転移酵素) / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / CELL JUNCTION (細胞結合) / CELL MEMBRANE (細胞膜) / LONG TERM POTENTIATION / BRAIN (脳) / KINASE (キナーゼ) / SYNAPSE (シナプス) / MEMBRANE (生体膜) / NMDA RECEPTOR SIGNALLING / PHOSPHOPROTEIN / CALMODULIN-BINDING / NUCLEOTIDE-BINDING | ||||||
機能・相同性 | 機能・相同性情報 peptidyl-threonine autophosphorylation / regulation of endocannabinoid signaling pathway / calcium- and calmodulin-dependent protein kinase complex / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / regulation of neurotransmitter secretion / dendritic spine development / positive regulation of calcium ion transport / Trafficking of AMPA receptors / negative regulation of hydrolase activity ...peptidyl-threonine autophosphorylation / regulation of endocannabinoid signaling pathway / calcium- and calmodulin-dependent protein kinase complex / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / regulation of neurotransmitter secretion / dendritic spine development / positive regulation of calcium ion transport / Trafficking of AMPA receptors / negative regulation of hydrolase activity / Assembly and cell surface presentation of NMDA receptors / calmodulin-dependent protein kinase activity / regulation of mitochondrial membrane permeability involved in apoptotic process / CaMK IV-mediated phosphorylation of CREB / Negative regulation of NMDA receptor-mediated neuronal transmission / positive regulation of cardiac muscle cell apoptotic process / Unblocking of NMDA receptors, glutamate binding and activation / regulation of neuronal synaptic plasticity / Phase 0 - rapid depolarisation / Ion transport by P-type ATPases / 長期増強 / Regulation of MECP2 expression and activity / HSF1-dependent transactivation / glutamate receptor binding / cellular response to interferon-beta / Ion homeostasis / Ras activation upon Ca2+ influx through NMDA receptor / response to ischemia / angiotensin-activated signaling pathway / G1/S transition of mitotic cell cycle / RAF activation / positive regulation of receptor signaling pathway via JAK-STAT / cellular response to type II interferon / Signaling by RAF1 mutants / endocytic vesicle membrane / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / calcium ion transport / Interferon gamma signaling / Signaling by BRAF and RAF1 fusions / Ca2+ pathway / positive regulation of NF-kappaB transcription factor activity / kinase activity / RAF/MAP kinase cascade / peptidyl-serine phosphorylation / 樹状突起スパイン / postsynaptic density / protein autophosphorylation / calmodulin binding / neuron projection / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / protein homodimerization activity / ミトコンドリア / 核質 / ATP binding / identical protein binding / metal ion binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 | ||||||
生物種 | HOMO SAPIENS (ヒト) | ||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å | ||||||
データ登録者 | Pike, A.C.W. / Rellos, P. / King, O. / Salah, E. / Parizotto, E. / Fedorov, O. / Shrestha, L. / Burgess-Brown, N. / Roos, A. / Murray, J.W. ...Pike, A.C.W. / Rellos, P. / King, O. / Salah, E. / Parizotto, E. / Fedorov, O. / Shrestha, L. / Burgess-Brown, N. / Roos, A. / Murray, J.W. / von Delft, F. / Edwards, A. / Arrowsmith, C.H. / Wikstroem, M. / Bountra, C. / Knapp, S. | ||||||
引用 | ジャーナル: Plos Biol. / 年: 2010 タイトル: Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation. 著者: Rellos, P. / Pike, A.C.W. / Niesen, F.H. / Salah, E. / Lee, W.H. / von Delft, F. / Knapp, S. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 2vz6.cif.gz | 138.7 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb2vz6.ent.gz | 108.1 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 2vz6.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/vz/2vz6 ftp://data.pdbj.org/pub/pdb/validation_reports/vz/2vz6 | HTTPS FTP |
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-関連構造データ
-リンク
-集合体
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