Entry Database : PDB / ID : 5mrd Structure visualization Downloads & linksTitle Human PDK1-PKCiota Kinase Chimera in Complex with Allosteric Compound PS267 Bound to the PIF-Pocket Components3-phosphoinositide-dependent protein kinase 1 Details Keywords TRANSFERASE / Protein Kinase / Allosteric Regulation / Small Compounds / PIF-pocketFunction / homology Function and homology informationFunction Domain/homology Component
3-phosphoinositide-dependent protein kinase activity / Activation of AKT2 / regulation of mast cell degranulation / negative regulation of toll-like receptor signaling pathway / type B pancreatic cell development / positive regulation of phospholipase activity / RSK activation / hyperosmotic response / regulation of canonical NF-kappaB signal transduction / positive regulation of vascular endothelial cell proliferation ... 3-phosphoinositide-dependent protein kinase activity / Activation of AKT2 / regulation of mast cell degranulation / negative regulation of toll-like receptor signaling pathway / type B pancreatic cell development / positive regulation of phospholipase activity / RSK activation / hyperosmotic response / regulation of canonical NF-kappaB signal transduction / positive regulation of vascular endothelial cell proliferation / negative regulation of cardiac muscle cell apoptotic process / phospholipase activator activity / positive regulation of sprouting angiogenesis / Constitutive Signaling by AKT1 E17K in Cancer / CD28 dependent PI3K/Akt signaling / phospholipase binding / positive regulation of blood vessel endothelial cell migration / Role of LAT2/NTAL/LAB on calcium mobilization / Estrogen-stimulated signaling through PRKCZ / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / negative regulation of endothelial cell apoptotic process / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / extrinsic apoptotic signaling pathway / RHO GTPases activate PKNs / cellular response to epidermal growth factor stimulus / GPVI-mediated activation cascade / T cell costimulation / activation of protein kinase B activity / Integrin signaling / insulin-like growth factor receptor signaling pathway / positive regulation of release of sequestered calcium ion into cytosol / VEGFR2 mediated vascular permeability / VEGFR2 mediated cell proliferation / cell projection / calcium-mediated signaling / positive regulation of protein localization to plasma membrane / peptidyl-threonine phosphorylation / negative regulation of transforming growth factor beta receptor signaling pathway / negative regulation of protein kinase activity / epidermal growth factor receptor signaling pathway / CLEC7A (Dectin-1) signaling / FCERI mediated NF-kB activation / G beta:gamma signalling through PI3Kgamma / cellular response to insulin stimulus / positive regulation of angiogenesis / Regulation of TP53 Degradation / cell migration / Downstream TCR signaling / insulin receptor signaling pathway / PIP3 activates AKT signaling / cytoplasmic vesicle / actin cytoskeleton organization / protein autophosphorylation / postsynaptic density / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / non-specific serine/threonine protein kinase / intracellular signal transduction / protein phosphorylation / focal adhesion / protein serine kinase activity / protein serine/threonine kinase activity / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function PDK1-type, PH domain / PDPK1 family / PH domain / PH-like domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. ... PDK1-type, PH domain / PDPK1 family / PH domain / PH-like domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.41 Å DetailsAuthors Arencibia, J.M. / Froehner, W. / Krupa, M. / Pastor-Flores, D. / Merker, P. / Oellerich, T. / Neimanis, S. / Schmithals, C. / Koeberle, V. / Suess, E. ...Arencibia, J.M. / Froehner, W. / Krupa, M. / Pastor-Flores, D. / Merker, P. / Oellerich, T. / Neimanis, S. / Schmithals, C. / Koeberle, V. / Suess, E. / Zeuzem, S. / Stark, H. / Piiper, A. / Odadzic, D. / Schulze, J.O. / Biondi, R.M. Funding support Germany, 3items Details Hide detailsOrganization Grant number Country German Research Foundation BI 1044/2-3 Germany German Research Foundation BI 1044/4-1 Germany German Research Foundation BI 1044/8-1 Germany
CitationJournal : ACS Chem. Biol. / Year : 2017Title : An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms.Authors: Arencibia, J.M. / Frohner, W. / Krupa, M. / Pastor-Flores, D. / Merker, P. / Oellerich, T. / Neimanis, S. / Schmithals, C. / Koberle, V. / Su, E. / Zeuzem, S. / Stark, H. / Piiper, A. / ... Authors : Arencibia, J.M. / Frohner, W. / Krupa, M. / Pastor-Flores, D. / Merker, P. / Oellerich, T. / Neimanis, S. / Schmithals, C. / Koberle, V. / Su, E. / Zeuzem, S. / Stark, H. / Piiper, A. / Odadzic, D. / Schulze, J.O. / Biondi, R.M. History Deposition Dec 22, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 18, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jan 25, 2017 Group : Database referencesRevision 1.2 Mar 1, 2017 Group : Database referencesRevision 1.3 Oct 16, 2019 Group : Author supporting evidence / Data collection / Category : pdbx_audit_support / reflns_shell / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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