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Structure paper

TitleStructure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
Journal, issue, pagesPlos Biol., Vol. 8, Page 426-, Year 2010
Publish dateMar 26, 2007 (structure data deposition date)
AuthorsRellos, P. / Pike, A.C.W. / Niesen, F.H. / Salah, E. / Lee, W.H. / von Delft, F. / Knapp, S.
External linksPlos Biol. / PubMed:20668654
MethodsX-ray diffraction
Resolution1.9 - 2.7 Å
Structure data

PDB-2ux0:
Structure of the oligomerisation domain of calcium-calmodulin dependent protein kinase II gamma
Method: X-RAY DIFFRACTION / Resolution: 2.46 Å

PDB-2v7o:
Crystal structure of human calcium-calmodulin-dependent protein kinase II gamma
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-2vn9:
Crystal Structure of Human Calcium Calmodulin dependent Protein Kinase II delta isoform 1, CAMKD
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2vz6:
Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2w2c:
STRUCTURE OF THE TETRADECAMERIC OLIGOMERISATION DOMAIN OF CALCIUM- CALMODULIN DEPENDENT PROTEIN KINASE II DELTA
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-2wel:
Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-GLY:
GLYCINE

ChemComp-HOH:
WATER

ChemComp-DRN:
BISINDOLYLMALEIMIDE IX / inhibitor*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-CL:
Unknown entry

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-GVD:
[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE

ChemComp-FEF:
(2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}

ChemComp-PGO:
S-1,2-PROPANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-CD:
Unknown entry

ChemComp-K88:
(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CALMODULIN / PROTEIN KINASE / OLIGOMERISATION DOMAIN / SERINE- THREONINE KINASE / ATP-BINDING / KINASE / NUCLEOTIDE-BINDING / SERINE/THREONINE-PROTEIN KINASE / TRANSFERASE. / S/T KINASE / PHOSPHORYLATION / CALMODULIN-BINDING / SERINE-THREONINE KINASE / CELLULAR DIFFERENTIATION / VASCULAR SMOOTH MUSCLE / PHOSPHOPROTEIN / CELL JUNCTION / CELL MEMBRANE / LONG TERM POTENTIATION / BRAIN / SYNAPSE / MEMBRANE / NMDA RECEPTOR SIGNALLING / CALMODULIN BINDING

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