2VZ6
Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804
Summary for 2VZ6
Entry DOI | 10.2210/pdb2vz6/pdb |
Descriptor | CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}, S-1,2-PROPANEDIOL, ... (4 entities in total) |
Functional Keywords | transferase, serine/threonine-protein kinase, atp-binding, cell junction, cell membrane, long term potentiation, brain, kinase, synapse, membrane, nmda receptor signalling, phosphoprotein, calmodulin-binding, nucleotide-binding |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell junction, synapse, presynaptic cell membrane : Q9UQM7 |
Total number of polymer chains | 2 |
Total formula weight | 72242.84 |
Authors | Pike, A.C.W.,Rellos, P.,King, O.,Salah, E.,Parizotto, E.,Fedorov, O.,Shrestha, L.,Burgess-Brown, N.,Roos, A.,Murray, J.W.,von Delft, F.,Edwards, A.,Arrowsmith, C.H.,Wikstroem, M.,Bountra, C.,Knapp, S. (deposition date: 2008-07-30, release date: 2008-08-26, Last modification date: 2023-12-13) |
Primary citation | Rellos, P.,Pike, A.C.W.,Niesen, F.H.,Salah, E.,Lee, W.H.,von Delft, F.,Knapp, S. Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation. Plos Biol., 8:426-, 2010 Cited by PubMed: 20668654DOI: 10.1371/JOURNAL.PBIO.1000426 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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