- PDB-4rbw: Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Ar... -
+
Open data
ID or keywords:
Loading...
-
Basic information
Entry
Database: PDB / ID: 4rbw
Title
Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant)
Components
Defensin-5
Keywords
ANTIMICROBIAL PROTEIN / MUTANT T7R E21R-HD5 / BETA-SHEET / ANTIMICROBIAL PEPTIDE / PANETH CELLS DEFENSIN / HUMAN ALPHA-DEFENSIN
Function / homology
Function and homology information
positive regulation of membrane permeability / Defensins / disruption of plasma membrane integrity in another organism / killing by host of symbiont cells / Alpha-defensins / defense response to fungus / transport vesicle / innate immune response in mucosa / secretory granule / positive regulation of interleukin-8 production ...positive regulation of membrane permeability / Defensins / disruption of plasma membrane integrity in another organism / killing by host of symbiont cells / Alpha-defensins / defense response to fungus / transport vesicle / innate immune response in mucosa / secretory granule / positive regulation of interleukin-8 production / Golgi lumen / antimicrobial humoral immune response mediated by antimicrobial peptide / antibacterial humoral response / midbody / cellular response to lipopolysaccharide / secretory granule lumen / protein homotetramerization / defense response to Gram-negative bacterium / killing of cells of another organism / defense response to Gram-positive bacterium / intracellular membrane-bounded organelle / innate immune response / protein homodimerization activity / extracellular space / extracellular region Similarity search - Function
Resolution: 1.5→36.077 Å / Cor.coef. Fo:Fc: 0.964 / Cor.coef. Fo:Fc free: 0.951 / SU B: 2.978 / SU ML: 0.061 / Cross valid method: THROUGHOUT / ESU R: 0.098 / ESU R Free: 0.098 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.22131
766
5 %
RANDOM
Rwork
0.18205
-
-
-
obs
0.1841
14565
90.46 %
-
all
-
16081
-
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK