Entry Database : PDB / ID : 2aww Structure visualization Downloads & linksTitle Synapse associated protein 97 PDZ2 domain variant C378G with C-terminal GluR-A peptide Components18-residue C-terminal peptide from glutamate receptor, ionotropic, AMPA1 Synapse associated protein 97 DetailsKeywords MEMBRANE PROTEIN / synaptic signaling / trafficking proteinFunction / homology Function and homology informationFunction Domain/homology Component
tissue morphogenesis / regulation of protein localization to synapse / regulation of potassium ion import / L27 domain binding / regulation of potassium ion export across plasma membrane / MPP7-DLG1-LIN7 complex / membrane raft organization / Cargo concentration in the ER / cellular response to amine stimulus / axonal spine ... tissue morphogenesis / regulation of protein localization to synapse / regulation of potassium ion import / L27 domain binding / regulation of potassium ion export across plasma membrane / MPP7-DLG1-LIN7 complex / membrane raft organization / Cargo concentration in the ER / cellular response to amine stimulus / axonal spine / hard palate development / COPII-mediated vesicle transport / positive regulation of membrane potential / establishment of centrosome localization / negative regulation of p38MAPK cascade / cortical microtubule organization / embryonic skeletal system morphogenesis / astral microtubule organization / cellular response to ammonium ion / structural constituent of postsynaptic density / lateral loop / reproductive structure development / immunological synapse formation / myelin sheath abaxonal region / receptor localization to synapse / peristalsis / cell projection membrane / smooth muscle tissue development / paranode region of axon / myosin V binding / neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration / bicellular tight junction assembly / positive regulation of potassium ion transport / Trafficking of AMPA receptors / neuron spine / Activation of Ca-permeable Kainate Receptor / node of Ranvier / regulation of ventricular cardiac muscle cell action potential / protein-containing complex localization / response to arsenic-containing substance / establishment or maintenance of epithelial cell apical/basal polarity / cellular response to dsRNA / dendritic spine membrane / amyloid precursor protein metabolic process / Synaptic adhesion-like molecules / RAF/MAP kinase cascade / long-term synaptic depression / lens development in camera-type eye / endothelial cell proliferation / beta-2 adrenergic receptor binding / cellular response to peptide hormone stimulus / ureteric bud development / regulation of myelination / neurotransmitter receptor localization to postsynaptic specialization membrane / protein kinase A binding / cortical actin cytoskeleton organization / branching involved in ureteric bud morphogenesis / negative regulation of G1/S transition of mitotic cell cycle / spinal cord development / positive regulation of actin filament polymerization / neuronal cell body membrane / Activation of AMPA receptors / receptor clustering / perisynaptic space / AMPA glutamate receptor activity / kinesin binding / Trafficking of GluR2-containing AMPA receptors / response to lithium ion / regulation of postsynaptic membrane neurotransmitter receptor levels / immunoglobulin binding / microvillus / AMPA glutamate receptor complex / adenylate cyclase binding / cellular response to organic cyclic compound / ionotropic glutamate receptor complex / immunological synapse / excitatory synapse / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / neuronal action potential / basement membrane / lateral plasma membrane / asymmetric synapse / G-protein alpha-subunit binding / regulation of receptor recycling / potassium channel regulator activity / bicellular tight junction / regulation of postsynaptic membrane potential / Unblocking of NMDA receptors, glutamate binding and activation / phosphatase binding / postsynaptic density, intracellular component / positive regulation of synaptic transmission / glutamate receptor binding / long-term memory / negative regulation of T cell proliferation / T cell proliferation / response to electrical stimulus / glutamate-gated receptor activity / glutamate-gated calcium ion channel activity / presynaptic active zone membrane / response to fungicide Similarity search - Function L27-1 / L27_1 / domain in receptor targeting proteins Lin-2 and Lin-7 / L27 domain / L27 domain profile. / L27 domain superfamily / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors ... L27-1 / L27_1 / domain in receptor targeting proteins Lin-2 and Lin-7 / L27 domain / L27 domain profile. / L27 domain superfamily / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / : / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / PDZ domain / Pdz3 Domain / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / PDZ domain / SH3 domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Periplasmic binding protein-like I / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Roll / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.21 Å DetailsAuthors Von Ossowski, I. / Oksanen, E. / Von Ossowski, L. / Cai, C. / Sundberg, M. / Goldman, A. / Keinanen, K. CitationJournal : Febs J. / Year : 2006Title : Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptideAuthors : von Ossowski, I. / Oksanen, E. / von Ossowski, L. / Cai, C. / Sundberg, M. / Goldman, A. / Keinanen, K. History Deposition Sep 2, 2005 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Aug 29, 2006 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Oct 11, 2017 Group : Refinement description / Category : software / Item : _software.classification / _software.nameRevision 1.4 Nov 10, 2021 Group : Database references / Category : database_2 / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.detailsRevision 1.5 May 29, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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