Entry Database : PDB / ID : 4oaj Structure visualization Downloads & linksTitle Crystal structure of the complex between SAP97 PDZ2 and 5HT2A receptor peptide Components5-hydroxytryptamine receptor 2A peptide Disks large homolog 1 DetailsKeywords PROTEIN BINDING / PDZ domain / 5HT2A receptorFunction / homology Function and homology informationFunction Domain/homology Component
T cell cytokine production / Serotonin receptors / protein-containing complex localization => GO:0031503 / regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / : / Activation of Ca-permeable Kainate Receptor / protein localization to cytoskeleton / tissue morphogenesis / : / regulation of protein localization to synapse ... T cell cytokine production / Serotonin receptors / protein-containing complex localization => GO:0031503 / regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / : / Activation of Ca-permeable Kainate Receptor / protein localization to cytoskeleton / tissue morphogenesis / : / regulation of protein localization to synapse / regulation of potassium ion import / Synaptic adhesion-like molecules / L27 domain binding / regulation of potassium ion export across plasma membrane / MPP7-DLG1-LIN7 complex / 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding / : / Unblocking of NMDA receptors, glutamate binding and activation / phospholipase C-activating serotonin receptor signaling pathway / positive regulation of phosphatidylinositol biosynthetic process / Trafficking of AMPA receptors / membrane raft organization / hard palate development / RAF/MAP kinase cascade / establishment of centrosome localization / : / : / serotonin receptor signaling pathway / cortical microtubule organization / negative regulation of p38MAPK cascade / cell death / receptor localization to synapse / artery smooth muscle contraction / embryonic skeletal system morphogenesis / astral microtubule organization / response to xenobiotic stimulus => GO:0009410 / structural constituent of postsynaptic density / lateral loop / cell body fiber / reproductive structure development / myelin sheath abaxonal region / immunological synapse formation / urinary bladder smooth muscle contraction / peristalsis / cell projection membrane / paranode region of axon / smooth muscle tissue development / positive regulation of developmental growth / serotonin binding / bicellular tight junction assembly / positive regulation of potassium ion transport / regulation of ventricular cardiac muscle cell action potential / amyloid precursor protein metabolic process / node of Ranvier / negative regulation of synaptic transmission, glutamatergic / G protein-coupled serotonin receptor activity / positive regulation of multicellular organism growth / sleep / establishment or maintenance of epithelial cell apical/basal polarity / neurotransmitter receptor activity / positive regulation of kinase activity / G alpha (q) signalling events / endothelial cell proliferation / neurotransmitter receptor localization to postsynaptic specialization membrane / lens development in camera-type eye / ureteric bud development / regulation of myelination / mitogen-activated protein kinase kinase binding / temperature homeostasis / cortical actin cytoskeleton organization / regulation of synaptic vesicle exocytosis / branching involved in ureteric bud morphogenesis / regulation of dopamine secretion / positive regulation of actin filament polymerization / receptor clustering / activation of protein kinase activity / behavioral response to cocaine / postsynaptic density, intracellular component / detection of temperature stimulus involved in sensory perception of pain / plasma membrane => GO:0005886 / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / microvillus / negative regulation of potassium ion transport / kinesin binding / activation of phospholipase C activity / immunological synapse / negative regulation of mitotic cell cycle / basement membrane / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / bicellular tight junction / G-protein alpha-subunit binding / potassium channel regulator activity / lateral plasma membrane / positive regulation of fat cell differentiation / phosphatase binding / detection of mechanical stimulus involved in sensory perception of pain / release of sequestered calcium ion into cytosol / positive regulation of vasoconstriction / sensory perception of pain / negative regulation of T cell proliferation Similarity search - Function 5-Hydroxytryptamine 2A receptor / L27-1 / L27_1 / 5-hydroxytryptamine receptor family / domain in receptor targeting proteins Lin-2 and Lin-7 / L27 domain / L27 domain profile. / Polyubiquitination (PEST) N-terminal domain of MAGUK / L27 domain superfamily / Disks large homologue 1, N-terminal PEST domain ... 5-Hydroxytryptamine 2A receptor / L27-1 / L27_1 / 5-hydroxytryptamine receptor family / domain in receptor targeting proteins Lin-2 and Lin-7 / L27 domain / L27 domain profile. / Polyubiquitination (PEST) N-terminal domain of MAGUK / L27 domain superfamily / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / PDZ domain / Pdz3 Domain / Serpentine type 7TM GPCR chemoreceptor Srsx / PDZ domain / SH3 domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Src homology 3 domains / G-protein coupled receptors family 1 signature. / SH3-like domain superfamily / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Src homology 3 (SH3) domain profile. / SH3 domain / Roll / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.3 Å DetailsAuthors Pandalaneni, S. / Dorr, L. / Mayans, O. / Lian, L.-Y. CitationJournal : To be Published Title : Crystal structure of the complex between SAP97 PDZ2 and 5HT2A receptor peptideAuthors : Pandalaneni, S. / Dorr, L. / Mayans, O. / Lian, L.-Y. History Deposition Jan 4, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 29, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Jan 24, 2018 Group : Database references / Structure summary / Category : audit_author / citation_author / Item : _audit_author.name / _citation_author.nameRevision 1.2 Feb 28, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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